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- W4283326981 endingPage "936" @default.
- W4283326981 startingPage "936" @default.
- W4283326981 abstract "The skin has a multifactorial aging process, caused by both intrinsic and extrinsic factors. A major theory of aging involves cellular senescence or apoptosis resulting from oxidative damage as the skin's antioxidant system tends to weaken with age. The human microbiota is a complex ecosystem that is made up of microorganisms (bacteria, fungi, and viruses). Both gut and skin microbiota have essential roles in the protection against invading pathogens, mediating inflammatory conditions, and the modulation of the immune system which is involved in both innate and adaptive immune responses. However, the human microbiome could be changed during the life stage and affected by various perturbations. An alteration of the intestinal bacteria results in microbial dysbiosis which is associated with the influence of various diseases, including aging. The skin interactome is a novel integration of the genome-microbiome-exposome that plays a significant role in skin aging and skin health. Mitigating the negative impacts of factors influencing the skin interactome should be the future strategy to protect, prevent, and delay skin aging along with preserving healthy skin conditions. This review summarizes the current evidence on how human microbiomes affect skin aging and demonstrates the possible interventions, relating to human microbiomes, to modulate skin health and aging. Probiotics-based products are currently available mainly for the add-on treatment of many dermatologic conditions. However, at this point, there are limited clinical studies on skin anti-aging purposes and more are required as this evolving concept is on the rise and might provide an insight into future therapeutic options." @default.
- W4283326981 created "2022-06-24" @default.
- W4283326981 creator A5015818483 @default.
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- W4283326981 creator A5064451870 @default.
- W4283326981 creator A5078446683 @default.
- W4283326981 creator A5082543647 @default.
- W4283326981 date "2022-06-22" @default.
- W4283326981 modified "2023-09-26" @default.
- W4283326981 title "How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives" @default.
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