Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283332783> ?p ?o ?g. }
- W4283332783 abstract "Nuclear pore complexes (NPCs) mediate communication between the nucleus and the cytoplasm, and regulate gene expression by interacting with transcription and mRNA export factors. Lysine acetyltransferases (KATs) promote transcription through acetylation of chromatin-associated proteins. We find that Esa1, the KAT subunit of the yeast NuA4 complex, also acetylates the nuclear pore basket component Nup60 to promote mRNA export. Acetylation of Nup60 recruits the mRNA export factor Sac3, the scaffolding subunit of the Transcription and Export 2 (TREX-2) complex, to the nuclear basket. The Esa1-mediated nuclear export of mRNAs in turn promotes entry into S phase, which is inhibited by the Hos3 deacetylase in G1 daughter cells to restrain their premature commitment to a new cell division cycle. This mechanism is not only limited to G1/S-expressed genes but also inhibits the expression of the nutrient-regulated GAL1 gene specifically in daughter cells. Overall, these results reveal how acetylation can contribute to the functional plasticity of NPCs in mother and daughter yeast cells. In addition, our work demonstrates dual gene expression regulation by the evolutionarily conserved NuA4 complex, at the level of transcription and at the stage of mRNA export by modifying the nucleoplasmic entrance to nuclear pores." @default.
- W4283332783 created "2022-06-24" @default.
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- W4283332783 date "2022-06-23" @default.
- W4283332783 modified "2023-10-18" @default.
- W4283332783 title "Nuclear pore complex acetylation regulates <scp>mRNA</scp> export and cell cycle commitment in budding yeast" @default.
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- W4283332783 doi "https://doi.org/10.15252/embj.2021110271" @default.
- W4283332783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35735140" @default.
- W4283332783 hasPublicationYear "2022" @default.
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