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- W4283363140 endingPage "6961" @default.
- W4283363140 startingPage "6961" @default.
- W4283363140 abstract "The development of midbrain dopaminergic (DA) neurons requires a fine temporal and spatial regulation of a very specific gene expression program. Here, we report that during mouse brain development, the microRNA (miR-) 204/211 is present at a high level in a subset of DA precursors expressing the transcription factor Lmx1a, an early determinant for DA-commitment, but not in more mature neurons expressing Th or Pitx3. By combining different in vitro model systems of DA differentiation, we show that the levels of Lmx1a influence the expression of miR-204/211. Using published transcriptomic data, we found a significant enrichment of miR-204/211 target genes in midbrain dopaminergic neurons where Lmx1a was selectively deleted at embryonic stages. We further demonstrated that miR-204/211 controls the timing of the DA differentiation by directly downregulating the expression of Nurr1, a late DA differentiation master gene. Thus, our data indicate the Lmx1a-miR-204/211-Nurr1 axis as a key component in the cascade of events that ultimately lead to mature midbrain dopaminergic neurons differentiation and point to miR-204/211 as the molecular switch regulating the timing of Nurr1 expression." @default.
- W4283363140 created "2022-06-25" @default.
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- W4283363140 date "2022-06-23" @default.
- W4283363140 modified "2023-10-01" @default.
- W4283363140 title "Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation" @default.
- W4283363140 cites W1560020441 @default.
- W4283363140 cites W1584433563 @default.
- W4283363140 cites W1762505455 @default.
- W4283363140 cites W1919367720 @default.
- W4283363140 cites W1963718798 @default.
- W4283363140 cites W1972515739 @default.
- W4283363140 cites W1979113560 @default.
- W4283363140 cites W1981862471 @default.
- W4283363140 cites W1985646074 @default.
- W4283363140 cites W1987167495 @default.
- W4283363140 cites W1989217980 @default.
- W4283363140 cites W1991252862 @default.
- W4283363140 cites W2002526679 @default.
- W4283363140 cites W2012020061 @default.
- W4283363140 cites W2014793858 @default.
- W4283363140 cites W2019028138 @default.
- W4283363140 cites W2047462905 @default.
- W4283363140 cites W2048833489 @default.
- W4283363140 cites W2054990893 @default.
- W4283363140 cites W2072837173 @default.
- W4283363140 cites W2073489542 @default.
- W4283363140 cites W2074084746 @default.
- W4283363140 cites W2078704469 @default.
- W4283363140 cites W2080320998 @default.
- W4283363140 cites W2080793115 @default.
- W4283363140 cites W2082347868 @default.
- W4283363140 cites W2085367342 @default.
- W4283363140 cites W2086046051 @default.
- W4283363140 cites W2088387883 @default.
- W4283363140 cites W2095606605 @default.
- W4283363140 cites W2111525324 @default.
- W4283363140 cites W2118176338 @default.
- W4283363140 cites W2119936622 @default.
- W4283363140 cites W2134629862 @default.
- W4283363140 cites W2134633634 @default.
- W4283363140 cites W2135920287 @default.
- W4283363140 cites W2136541538 @default.
- W4283363140 cites W2137927007 @default.
- W4283363140 cites W2149146453 @default.
- W4283363140 cites W2149756019 @default.
- W4283363140 cites W2152092558 @default.
- W4283363140 cites W2152301173 @default.
- W4283363140 cites W2154044387 @default.
- W4283363140 cites W2160440447 @default.
- W4283363140 cites W2165221709 @default.
- W4283363140 cites W2168665115 @default.
- W4283363140 cites W2171398108 @default.
- W4283363140 cites W2207577758 @default.
- W4283363140 cites W2271744335 @default.
- W4283363140 cites W2435834489 @default.
- W4283363140 cites W2460664196 @default.
- W4283363140 cites W2461686980 @default.
- W4283363140 cites W2461893049 @default.
- W4283363140 cites W2513128864 @default.
- W4283363140 cites W2518602763 @default.
- W4283363140 cites W2544973020 @default.
- W4283363140 cites W2586256820 @default.
- W4283363140 cites W2587065376 @default.
- W4283363140 cites W2604541805 @default.
- W4283363140 cites W2607440944 @default.
- W4283363140 cites W2761280295 @default.
- W4283363140 cites W2765979407 @default.
- W4283363140 cites W2769928372 @default.
- W4283363140 cites W2790653818 @default.
- W4283363140 cites W2791737042 @default.
- W4283363140 cites W2808339677 @default.
- W4283363140 cites W2911387232 @default.
- W4283363140 cites W2913337535 @default.
- W4283363140 cites W2946227876 @default.
- W4283363140 cites W2957522866 @default.
- W4283363140 cites W2969228397 @default.
- W4283363140 cites W2981484918 @default.
- W4283363140 cites W2997022986 @default.
- W4283363140 cites W2997395188 @default.
- W4283363140 cites W3033355323 @default.
- W4283363140 cites W3127277606 @default.
- W4283363140 cites W3129631769 @default.
- W4283363140 cites W3141223447 @default.
- W4283363140 cites W3156089745 @default.
- W4283363140 cites W3165619628 @default.
- W4283363140 cites W3171928187 @default.
- W4283363140 cites W3175499610 @default.