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• W4283364013 abstract "Humans, and many other species, are host to diverse symbionts. It is often suggested that the mutual benefits of host-microbe relationships can alone explain cooperative evolution. Here, we evaluate this hypothesis with evolutionary modelling. Our model predicts that mutual benefits are insufficient to drive cooperation in systems like the human microbiome, because of competition between symbionts. However, cooperation can emerge if hosts can exert control over symbionts, so long as there are constraints that limit symbiont counter evolution. We test our model with genomic data of two bacterial traits monitored by animal immune systems. In both cases, bacteria have evolved as predicted under host control, tending to lose flagella and maintain butyrate production when host-associated. Moreover, an analysis of bacteria that retain flagella supports the evolution of host control, via toll-like receptor 5, which limits symbiont counter evolution. Our work puts host control mechanisms, including the immune system, at the centre of microbiome evolution." @default.
• W4283364013 created "2022-06-25" @default.
• W4283364013 creator A5030739709 @default.
• W4283364013 creator A5040902914 @default.
• W4283364013 date "2022-06-22" @default.
• W4283364013 modified "2023-10-12" @default.
• W4283364013 title "Host control and the evolution of cooperation in host microbiomes" @default.
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