FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283373504> ?p ?o ?g. }

• W4283373504 abstract "Impaired intestinal barrier function and gut microbiota dysbiosis are believed to be related to exacerbation of acute pancreatitis (AP). As a bacterial cell wall peptidoglycan component, diaminopimelic acid (DAP) is a specific ligand of NOD1 that regulates the NOD1/RIP2/NF-kB signaling pathway. Here, we investigated the role of DAP in the crosstalk between the gut microbiota and pancreas during the occurrence of AP. Upregulation of NOD1/RIP2/NF-kB and elevated serum DAP levels were found in severe AP (SAP) model rats. The accumulation of DAP in SAP patients corroborated its ability to serve as an indicator of disease severity. Subsequently, SAP rats were treated with oral administration of the traditional Chinese medicine Qingyi Keli (QYKL) as well as neomycin, which can widely eliminate DAP-containing bacteria. Both QYKL and neomycin intervention ameliorated intestinal and pancreatic damage and systemic inflammation in SAP rats. Through 16S rDNA sequencing, we found that QYKL could rehabilitate the gut microbiota structure and selectively inhibit the overgrowth of enteric bacteria, such as Helicobacter and Lactobacillus, in SAP rats without affecting some protective strains, including Romboutsia and Allobaculum. Interestingly, we demonstrated that the decrease in serum DAP was accompanied by suppression of the NOD1/RIP2/NF-kB signaling pathway in both the intestine and pancreas of the two intervention groups. Taken together, these results suggested that the gut microbiota-DAP-NOD1/RIP2 signaling pathway might play a critical role in the progression of AP and that SAP could be alleviated via intervention in the signaling pathway. Our work provides new potential early warning indicators of SAP and targets for intervention." @default.
• W4283373504 created "2022-06-25" @default.
• W4283373504 creator A5010319430 @default.
• W4283373504 creator A5014282682 @default.
• W4283373504 creator A5020746135 @default.
• W4283373504 creator A5030128184 @default.
• W4283373504 creator A5031895786 @default.
• W4283373504 creator A5063006365 @default.
• W4283373504 creator A5065434498 @default.
• W4283373504 creator A5072362586 @default.
• W4283373504 creator A5072913663 @default.
• W4283373504 creator A5075662908 @default.
• W4283373504 creator A5076654526 @default.
• W4283373504 date "2022-06-22" @default.
• W4283373504 modified "2023-09-30" @default.
• W4283373504 title "Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis" @default.
• W4283373504 cites W1254022929 @default.
• W4283373504 cites W1477455032 @default.
• W4283373504 cites W1514224413 @default.
• W4283373504 cites W1969400474 @default.
• W4283373504 cites W2001166572 @default.
• W4283373504 cites W2017716899 @default.
• W4283373504 cites W2035855735 @default.
• W4283373504 cites W2040024879 @default.
• W4283373504 cites W2075228261 @default.
• W4283373504 cites W2099562804 @default.
• W4283373504 cites W2105409495 @default.
• W4283373504 cites W2119160047 @default.
• W4283373504 cites W2125309974 @default.
• W4283373504 cites W2126413585 @default.
• W4283373504 cites W2129036182 @default.
• W4283373504 cites W2134928825 @default.
• W4283373504 cites W2145758369 @default.
• W4283373504 cites W2152885278 @default.
• W4283373504 cites W2154069286 @default.
• W4283373504 cites W2328306899 @default.
• W4283373504 cites W2373701939 @default.
• W4283373504 cites W2412773516 @default.
• W4283373504 cites W2463960274 @default.
• W4283373504 cites W2512796610 @default.
• W4283373504 cites W2551464444 @default.
• W4283373504 cites W2555410788 @default.
• W4283373504 cites W2608822353 @default.
• W4283373504 cites W2609718657 @default.
• W4283373504 cites W2609721436 @default.
• W4283373504 cites W2611920505 @default.
• W4283373504 cites W2613987765 @default.
• W4283373504 cites W2761223061 @default.
• W4283373504 cites W2777900197 @default.
• W4283373504 cites W2781772043 @default.
• W4283373504 cites W2782975824 @default.
• W4283373504 cites W2790513932 @default.
• W4283373504 cites W2809585340 @default.
• W4283373504 cites W2902304754 @default.
• W4283373504 cites W2913483381 @default.
• W4283373504 cites W2921793293 @default.
• W4283373504 cites W2924081358 @default.
• W4283373504 cites W2936331020 @default.
• W4283373504 cites W2971944416 @default.
• W4283373504 cites W3000635792 @default.
• W4283373504 cites W3025216543 @default.
• W4283373504 cites W3099098454 @default.
• W4283373504 cites W4210998956 @default.
• W4283373504 cites W4230386260 @default.
• W4283373504 cites W4249270402 @default.
• W4283373504 cites W4299724776 @default.
• W4283373504 doi "https://doi.org/10.3389/fcimb.2022.838340" @default.
• W4283373504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35811665" @default.
• W4283373504 hasPublicationYear "2022" @default.
• W4283373504 type Work @default.
• W4283373504 citedByCount "1" @default.
• W4283373504 countsByYear W42833735042023 @default.
• W4283373504 crossrefType "journal-article" @default.
• W4283373504 hasAuthorship W4283373504A5010319430 @default.
• W4283373504 hasAuthorship W4283373504A5014282682 @default.
• W4283373504 hasAuthorship W4283373504A5020746135 @default.
• W4283373504 hasAuthorship W4283373504A5030128184 @default.
• W4283373504 hasAuthorship W4283373504A5031895786 @default.
• W4283373504 hasAuthorship W4283373504A5063006365 @default.
• W4283373504 hasAuthorship W4283373504A5065434498 @default.
• W4283373504 hasAuthorship W4283373504A5072362586 @default.
• W4283373504 hasAuthorship W4283373504A5072913663 @default.
• W4283373504 hasAuthorship W4283373504A5075662908 @default.
• W4283373504 hasAuthorship W4283373504A5076654526 @default.
• W4283373504 hasBestOaLocation W42833735041 @default.
• W4283373504 hasConcept C136449434 @default.
• W4283373504 hasConcept C203014093 @default.
• W4283373504 hasConcept C2776070231 @default.
• W4283373504 hasConcept C2776634448 @default.
• W4283373504 hasConcept C2776914184 @default.
• W4283373504 hasConcept C2777165150 @default.
• W4283373504 hasConcept C2777291061 @default.
• W4283373504 hasConcept C2779841869 @default.
• W4283373504 hasConcept C2781236682 @default.
• W4283373504 hasConcept C501593827 @default.
• W4283373504 hasConcept C523546767 @default.
• W4283373504 hasConcept C539455810 @default.
• W4283373504 hasConcept C54355233 @default.
• W4283373504 hasConcept C62478195 @default.
• W4283373504 hasConcept C7573103 @default.

• next