FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283375783> ?p ?o ?g. }

• W4283375783 endingPage "1847" @default.
• W4283375783 startingPage "1836" @default.
• W4283375783 abstract "Background: Non-small cell lung cancer (NSCLC) is associated with high morbidity and mortality. Dysregulation of lncRNAs leads to NSCLC progression. Objective: This study aims to explore the regulatory mechanism of lncRNA LINC01234 in NSCLC. Materials and Methods: LINC01234 expression in NSCLC cells was determined. Cell proliferation was detected using CCK-8, colony formation, and EDU assays after transfection of siRNA LINC01234 into H1299 cells and transfection of pcDNA3.1-LINC01234 into H1975 cells. Subcellular localization of LINC01234 was predicted and the binding relations between LINC01234 and miR-433-3p as well as miR-433-3p and GRB2 were verified. The expression levels of miR-433-3p and GRB2 in NSCLC cells were determined. Joint experiments of miR-433-3p inhibitor + si- LINC01234-1 or oe-GRB2 + si-LINC01234-1 were conducted to verify the role of miR-433-3p and GRB2 in NSCLC cell malignant proliferation. Results: LINC01234 was abundantly expressed in NSCLC cells. LINC01234 silencing reduced NSCLC cell proliferation while LINC01234 overexpression enhanced cell proliferation. LINC01234 competitively bound to miR-433-3p and miR-433-3p directly targeted GRB2. miR- 433-3p knockdown or GRB2 overexpression counteracted the repressive effect of LINC01234 silencing on NSCLC cell malignant proliferation. Conclusion: LINC01234 competitively bound to miR-433-3p and promoted GRB2 transcription to augment NSCLC cell malignant proliferation." @default.
• W4283375783 created "2022-06-25" @default.
• W4283375783 creator A5003799076 @default.
• W4283375783 creator A5011166808 @default.
• W4283375783 creator A5025399126 @default.
• W4283375783 creator A5035113720 @default.
• W4283375783 creator A5041125507 @default.
• W4283375783 creator A5058497975 @default.
• W4283375783 date "2023-08-01" @default.
• W4283375783 modified "2023-10-18" @default.
• W4283375783 title "The Role of the LINC01234/miR-433-3p/GRB2 ceRNA Network in NSCLC Cell Malignant Proliferation" @default.
• W4283375783 cites W2003521072 @default.
• W4283375783 cites W2010040849 @default.
• W4283375783 cites W2017922974 @default.
• W4283375783 cites W2053835153 @default.
• W4283375783 cites W2117977572 @default.
• W4283375783 cites W2118107482 @default.
• W4283375783 cites W2148512186 @default.
• W4283375783 cites W2160068229 @default.
• W4283375783 cites W2305841374 @default.
• W4283375783 cites W2560629363 @default.
• W4283375783 cites W2767061187 @default.
• W4283375783 cites W2768852352 @default.
• W4283375783 cites W2784371446 @default.
• W4283375783 cites W2789382357 @default.
• W4283375783 cites W2790084811 @default.
• W4283375783 cites W2800620450 @default.
• W4283375783 cites W2803045993 @default.
• W4283375783 cites W2885409821 @default.
• W4283375783 cites W2944889797 @default.
• W4283375783 cites W2949674037 @default.
• W4283375783 cites W2981564611 @default.
• W4283375783 cites W2989311094 @default.
• W4283375783 cites W2994642443 @default.
• W4283375783 cites W2994755653 @default.
• W4283375783 cites W2996407122 @default.
• W4283375783 cites W3005597885 @default.
• W4283375783 cites W3010776909 @default.
• W4283375783 cites W3011943132 @default.
• W4283375783 cites W3012575145 @default.
• W4283375783 cites W3034283341 @default.
• W4283375783 cites W3035731904 @default.
• W4283375783 cites W3039340919 @default.
• W4283375783 cites W3048451335 @default.
• W4283375783 cites W3083002682 @default.
• W4283375783 cites W3140389405 @default.
• W4283375783 cites W3182048312 @default.
• W4283375783 cites W2997604276 @default.
• W4283375783 doi "https://doi.org/10.2174/1386207325666220624093957" @default.
• W4283375783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35747966" @default.
• W4283375783 hasPublicationYear "2023" @default.
• W4283375783 type Work @default.
• W4283375783 citedByCount "1" @default.
• W4283375783 countsByYear W42833757832023 @default.
• W4283375783 crossrefType "journal-article" @default.
• W4283375783 hasAuthorship W4283375783A5003799076 @default.
• W4283375783 hasAuthorship W4283375783A5011166808 @default.
• W4283375783 hasAuthorship W4283375783A5025399126 @default.
• W4283375783 hasAuthorship W4283375783A5035113720 @default.
• W4283375783 hasAuthorship W4283375783A5041125507 @default.
• W4283375783 hasAuthorship W4283375783A5058497975 @default.
• W4283375783 hasConcept C104317684 @default.
• W4283375783 hasConcept C108636557 @default.
• W4283375783 hasConcept C119056186 @default.
• W4283375783 hasConcept C127561419 @default.
• W4283375783 hasConcept C143998085 @default.
• W4283375783 hasConcept C145059251 @default.
• W4283375783 hasConcept C1491633281 @default.
• W4283375783 hasConcept C173396325 @default.
• W4283375783 hasConcept C177917778 @default.
• W4283375783 hasConcept C2776256026 @default.
• W4283375783 hasConcept C502942594 @default.
• W4283375783 hasConcept C54009773 @default.
• W4283375783 hasConcept C54355233 @default.
• W4283375783 hasConcept C60365752 @default.
• W4283375783 hasConcept C62112901 @default.
• W4283375783 hasConcept C62203573 @default.
• W4283375783 hasConcept C62478195 @default.
• W4283375783 hasConcept C71924100 @default.
• W4283375783 hasConcept C81885089 @default.
• W4283375783 hasConcept C86803240 @default.
• W4283375783 hasConcept C95444343 @default.
• W4283375783 hasConceptScore W4283375783C104317684 @default.
• W4283375783 hasConceptScore W4283375783C108636557 @default.
• W4283375783 hasConceptScore W4283375783C119056186 @default.
• W4283375783 hasConceptScore W4283375783C127561419 @default.
• W4283375783 hasConceptScore W4283375783C143998085 @default.
• W4283375783 hasConceptScore W4283375783C145059251 @default.
• W4283375783 hasConceptScore W4283375783C1491633281 @default.
• W4283375783 hasConceptScore W4283375783C173396325 @default.
• W4283375783 hasConceptScore W4283375783C177917778 @default.
• W4283375783 hasConceptScore W4283375783C2776256026 @default.
• W4283375783 hasConceptScore W4283375783C502942594 @default.
• W4283375783 hasConceptScore W4283375783C54009773 @default.
• W4283375783 hasConceptScore W4283375783C54355233 @default.
• W4283375783 hasConceptScore W4283375783C60365752 @default.
• W4283375783 hasConceptScore W4283375783C62112901 @default.
• W4283375783 hasConceptScore W4283375783C62203573 @default.

• next