Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283376670> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4283376670 endingPage "218" @default.
- W4283376670 startingPage "211" @default.
- W4283376670 abstract "Introduction: Asthma is characterized by persistent inflammation, airway hypersensitivity and remodelling. Bone Morphogenetic Proteins belong to the Transforming Growth Factor Superfamily and have a similar signalling transduction pathway and common co-mediating protein. However, the BMPs role in the remodelling remains unclear; they appear to be involved in the airway inflammation and fibrogenesis process. Material and Methods: 60 patients with asthma and 48 healthy volunteers were recruited for the study. Blood samples were collected before, 1 h, 24 and 48 h after the allergen or the methacholine challenge test. Evaluation of BMP-4 and BMP-7 serum concentration and expression was performed using ELISA and real time PCR methods, respectively. Results: Statistically significant differences in BMP-7 concentration between healthy controls and asthmatics before the chal-lenge were noted. We found two statistically significant correlations: between the basal BMP-4 concentration and the FEV1(L) raw value and FEV1/FVC(%) index. We did not observe significant changes in the gene expression of BMP-4 and BMP-7 in different time points. Conclusions: Observed differences in BMP-7 concentration between asthmatic and healthy groups and correlations between BMP-4 concentration and some lung function test values may indicate the role of the BMPs in the etiopathogenesis of asthma. The unique characteristic of our study is the evaluation of BMPs serum levels, not in the bronchial epithelium." @default.
- W4283376670 created "2022-06-25" @default.
- W4283376670 creator A5001308400 @default.
- W4283376670 creator A5029340224 @default.
- W4283376670 creator A5049150028 @default.
- W4283376670 creator A5073089365 @default.
- W4283376670 creator A5086511271 @default.
- W4283376670 date "2022-06-22" @default.
- W4283376670 modified "2023-10-01" @default.
- W4283376670 title "The correlation of the BMP-4 and BMP-7 proteins of the TGFβ-BMP-SMAD pathway in the response to a specific and non-specific trigger in asthma." @default.
- W4283376670 doi "https://doi.org/10.5603/arm.87955" @default.
- W4283376670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35731115" @default.
- W4283376670 hasPublicationYear "2022" @default.
- W4283376670 type Work @default.
- W4283376670 citedByCount "0" @default.
- W4283376670 crossrefType "journal-article" @default.
- W4283376670 hasAuthorship W4283376670A5001308400 @default.
- W4283376670 hasAuthorship W4283376670A5029340224 @default.
- W4283376670 hasAuthorship W4283376670A5049150028 @default.
- W4283376670 hasAuthorship W4283376670A5073089365 @default.
- W4283376670 hasAuthorship W4283376670A5086511271 @default.
- W4283376670 hasBestOaLocation W42833766701 @default.
- W4283376670 hasConcept C104317684 @default.
- W4283376670 hasConcept C118131993 @default.
- W4283376670 hasConcept C125349252 @default.
- W4283376670 hasConcept C126322002 @default.
- W4283376670 hasConcept C134018914 @default.
- W4283376670 hasConcept C203014093 @default.
- W4283376670 hasConcept C2776042228 @default.
- W4283376670 hasConcept C2776914184 @default.
- W4283376670 hasConcept C2777714996 @default.
- W4283376670 hasConcept C2778024521 @default.
- W4283376670 hasConcept C2779306644 @default.
- W4283376670 hasConcept C2781080636 @default.
- W4283376670 hasConcept C31507581 @default.
- W4283376670 hasConcept C55493867 @default.
- W4283376670 hasConcept C71924100 @default.
- W4283376670 hasConcept C73834784 @default.
- W4283376670 hasConcept C86803240 @default.
- W4283376670 hasConceptScore W4283376670C104317684 @default.
- W4283376670 hasConceptScore W4283376670C118131993 @default.
- W4283376670 hasConceptScore W4283376670C125349252 @default.
- W4283376670 hasConceptScore W4283376670C126322002 @default.
- W4283376670 hasConceptScore W4283376670C134018914 @default.
- W4283376670 hasConceptScore W4283376670C203014093 @default.
- W4283376670 hasConceptScore W4283376670C2776042228 @default.
- W4283376670 hasConceptScore W4283376670C2776914184 @default.
- W4283376670 hasConceptScore W4283376670C2777714996 @default.
- W4283376670 hasConceptScore W4283376670C2778024521 @default.
- W4283376670 hasConceptScore W4283376670C2779306644 @default.
- W4283376670 hasConceptScore W4283376670C2781080636 @default.
- W4283376670 hasConceptScore W4283376670C31507581 @default.
- W4283376670 hasConceptScore W4283376670C55493867 @default.
- W4283376670 hasConceptScore W4283376670C71924100 @default.
- W4283376670 hasConceptScore W4283376670C73834784 @default.
- W4283376670 hasConceptScore W4283376670C86803240 @default.
- W4283376670 hasIssue "3" @default.
- W4283376670 hasLocation W42833766701 @default.
- W4283376670 hasLocation W42833766702 @default.
- W4283376670 hasOpenAccess W4283376670 @default.
- W4283376670 hasPrimaryLocation W42833766701 @default.
- W4283376670 hasRelatedWork W1574697834 @default.
- W4283376670 hasRelatedWork W1979091346 @default.
- W4283376670 hasRelatedWork W1994324715 @default.
- W4283376670 hasRelatedWork W2112903125 @default.
- W4283376670 hasRelatedWork W2141124705 @default.
- W4283376670 hasRelatedWork W2166429987 @default.
- W4283376670 hasRelatedWork W2352788820 @default.
- W4283376670 hasRelatedWork W2365122748 @default.
- W4283376670 hasRelatedWork W3026637588 @default.
- W4283376670 hasRelatedWork W4211160592 @default.
- W4283376670 hasVolume "90" @default.
- W4283376670 isParatext "false" @default.
- W4283376670 isRetracted "false" @default.
- W4283376670 workType "article" @default.