FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283381811> ?p ?o ?g. }

• W4283381811 endingPage "302" @default.
• W4283381811 startingPage "296" @default.
• W4283381811 abstract "Growing evidence suggests that ageing-associated alterations occur in both idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Here, we review the most recent literature on dysregulated ageing pathways in IPF and COPD and discuss how they may contribute to disease pathogenesis.Recent studies have shown that alveolar epithelial type II (ATII) cells undergo premature senescence under stress and that senescent ATII cells promote lung fibrogenesis. Some studies have explored the role of mitochondrial dysfunction in IPF. They have provided evidence that dysfunctional mitochondria are important contributors to fibrogenesis through release of damaged DNA and excessive formation of reactive oxygen species, whereas restoration of mitochondrial homeostasis may attenuate lung fibrosis. Insufficient autophagy has been shown to promote epithelial-to-mesenchymal transition and aberrant epithelial-fibroblast crosstalk, suggesting that autophagy augmentation may represent a potential therapeutic strategy. A number of studies have also explored the role of cellular senescence, mitochondrial homeostasis and autophagy in COPD.Several ageing mechanisms are dysregulated in the lungs of patients with IPF and COPD, although how they contribute to disease development and progression remains elusive. Genetic or pharmacologic attenuation of senescence-related pathways and elimination of senescent cells may represent a promising therapeutic strategy." @default.
• W4283381811 created "2022-06-25" @default.
• W4283381811 creator A5043303194 @default.
• W4283381811 creator A5059046962 @default.
• W4283381811 date "2022-07-01" @default.
• W4283381811 modified "2023-10-10" @default.
• W4283381811 title "Revealing the pathogenic and ageing-related mechanisms of the enigmatic idiopathic pulmonary fibrosis (and chronic obstructive pulmonary disease)" @default.
• W4283381811 cites W1586820518 @default.
• W4283381811 cites W1963983776 @default.
• W4283381811 cites W1966558304 @default.
• W4283381811 cites W1971300919 @default.
• W4283381811 cites W1997567430 @default.
• W4283381811 cites W2005574929 @default.
• W4283381811 cites W2036156384 @default.
• W4283381811 cites W2069519394 @default.
• W4283381811 cites W2072714570 @default.
• W4283381811 cites W2095835362 @default.
• W4283381811 cites W2109100155 @default.
• W4283381811 cites W2109882045 @default.
• W4283381811 cites W2117975450 @default.
• W4283381811 cites W2137274600 @default.
• W4283381811 cites W2154409238 @default.
• W4283381811 cites W2154846778 @default.
• W4283381811 cites W2158932224 @default.
• W4283381811 cites W2166215442 @default.
• W4283381811 cites W2166478007 @default.
• W4283381811 cites W2169986172 @default.
• W4283381811 cites W2170265183 @default.
• W4283381811 cites W2259646030 @default.
• W4283381811 cites W2266290735 @default.
• W4283381811 cites W2321684484 @default.
• W4283381811 cites W2513882409 @default.
• W4283381811 cites W2552567545 @default.
• W4283381811 cites W2606699511 @default.
• W4283381811 cites W2622200008 @default.
• W4283381811 cites W2791691790 @default.
• W4283381811 cites W2799479598 @default.
• W4283381811 cites W2890637767 @default.
• W4283381811 cites W2895021627 @default.
• W4283381811 cites W2912424917 @default.
• W4283381811 cites W2948081233 @default.
• W4283381811 cites W2951991612 @default.
• W4283381811 cites W2963688247 @default.
• W4283381811 cites W2965877420 @default.
• W4283381811 cites W2969184781 @default.
• W4283381811 cites W2972747187 @default.
• W4283381811 cites W2972860151 @default.
• W4283381811 cites W2987976092 @default.
• W4283381811 cites W2997884521 @default.
• W4283381811 cites W3002131808 @default.
• W4283381811 cites W3013922258 @default.
• W4283381811 cites W3021586450 @default.
• W4283381811 cites W3031389212 @default.
• W4283381811 cites W3035848569 @default.
• W4283381811 cites W3087158098 @default.
• W4283381811 cites W3089433670 @default.
• W4283381811 cites W3092447922 @default.
• W4283381811 cites W3093938386 @default.
• W4283381811 cites W3106470545 @default.
• W4283381811 cites W3128897102 @default.
• W4283381811 cites W3134680165 @default.
• W4283381811 cites W3143179777 @default.
• W4283381811 cites W3159652848 @default.
• W4283381811 cites W3182061583 @default.
• W4283381811 cites W3193447764 @default.
• W4283381811 cites W3199689348 @default.
• W4283381811 cites W3208599634 @default.
• W4283381811 cites W4234756901 @default.
• W4283381811 cites W4254423821 @default.
• W4283381811 doi "https://doi.org/10.1097/mcp.0000000000000876" @default.
• W4283381811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35749794" @default.
• W4283381811 hasPublicationYear "2022" @default.
• W4283381811 type Work @default.
• W4283381811 citedByCount "3" @default.
• W4283381811 countsByYear W42833818112023 @default.
• W4283381811 crossrefType "journal-article" @default.
• W4283381811 hasAuthorship W4283381811A5043303194 @default.
• W4283381811 hasAuthorship W4283381811A5059046962 @default.
• W4283381811 hasConcept C120665830 @default.
• W4283381811 hasConcept C121332964 @default.
• W4283381811 hasConcept C126322002 @default.
• W4283381811 hasConcept C142724271 @default.
• W4283381811 hasConcept C169822122 @default.
• W4283381811 hasConcept C190283241 @default.
• W4283381811 hasConcept C203014093 @default.
• W4283381811 hasConcept C203522944 @default.
• W4283381811 hasConcept C2776780178 @default.
• W4283381811 hasConcept C2777714996 @default.
• W4283381811 hasConcept C2778341716 @default.
• W4283381811 hasConcept C2779134260 @default.
• W4283381811 hasConcept C2780559512 @default.
• W4283381811 hasConcept C2781244666 @default.
• W4283381811 hasConcept C500499127 @default.
• W4283381811 hasConcept C522857546 @default.
• W4283381811 hasConcept C55493867 @default.
• W4283381811 hasConcept C63645605 @default.
• W4283381811 hasConcept C71924100 @default.
• W4283381811 hasConcept C86803240 @default.

• next