Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283394067> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4283394067 endingPage "95" @default.
- W4283394067 startingPage "90" @default.
- W4283394067 abstract "Organ shortage continues to be the forefront of problems facing clinical transplantation. Although xenografts serve as a promising alternative, its success is contingent upon further investigation into the mechanisms of cell-mediated xenograft rejection. Here, we explored the direct and indirect contribution of human immune cells in xenorecognition using human and murine in vitro coculture systems. Our data shows that human T cells directly recognized the xenogeneic MHC molecules since blocking of MHCs suppressed their proliferative response and cytokines production of IL-2 and IFN-γ. While B and NK cells alone did not generate a significant response, the combination of B and T cells promoted indirect xenorecognition by T cells as evidenced by an increase in B cell proliferative response. Overall, our data suggests that human T cells have the plasticity to recognize xenogeneic MHCs and contribute to xenograft rejection." @default.
- W4283394067 created "2022-06-25" @default.
- W4283394067 creator A5001367795 @default.
- W4283394067 creator A5027165298 @default.
- W4283394067 creator A5036642206 @default.
- W4283394067 creator A5066432533 @default.
- W4283394067 date "2022-08-01" @default.
- W4283394067 modified "2023-10-18" @default.
- W4283394067 title "Human T cells show plasticity for direct recognition of xenogeneic dendritic cells" @default.
- W4283394067 cites W1488262187 @default.
- W4283394067 cites W1546056821 @default.
- W4283394067 cites W1575742899 @default.
- W4283394067 cites W1618480967 @default.
- W4283394067 cites W1661544713 @default.
- W4283394067 cites W1828998075 @default.
- W4283394067 cites W1934640854 @default.
- W4283394067 cites W1979877646 @default.
- W4283394067 cites W2004005292 @default.
- W4283394067 cites W2086519181 @default.
- W4283394067 cites W2112196937 @default.
- W4283394067 cites W2129507272 @default.
- W4283394067 cites W2131692781 @default.
- W4283394067 cites W2132449452 @default.
- W4283394067 cites W2138099499 @default.
- W4283394067 cites W2150645978 @default.
- W4283394067 cites W2150749282 @default.
- W4283394067 cites W2151173049 @default.
- W4283394067 doi "https://doi.org/10.1016/j.imlet.2022.06.011" @default.
- W4283394067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35753524" @default.
- W4283394067 hasPublicationYear "2022" @default.
- W4283394067 type Work @default.
- W4283394067 citedByCount "0" @default.
- W4283394067 crossrefType "journal-article" @default.
- W4283394067 hasAuthorship W4283394067A5001367795 @default.
- W4283394067 hasAuthorship W4283394067A5027165298 @default.
- W4283394067 hasAuthorship W4283394067A5036642206 @default.
- W4283394067 hasAuthorship W4283394067A5066432533 @default.
- W4283394067 hasConcept C126322002 @default.
- W4283394067 hasConcept C129374314 @default.
- W4283394067 hasConcept C138885662 @default.
- W4283394067 hasConcept C194051981 @default.
- W4283394067 hasConcept C202751555 @default.
- W4283394067 hasConcept C203014093 @default.
- W4283394067 hasConcept C207936829 @default.
- W4283394067 hasConcept C2776090121 @default.
- W4283394067 hasConcept C2778137410 @default.
- W4283394067 hasConcept C2911091166 @default.
- W4283394067 hasConcept C41895202 @default.
- W4283394067 hasConcept C502942594 @default.
- W4283394067 hasConcept C54355233 @default.
- W4283394067 hasConcept C71924100 @default.
- W4283394067 hasConcept C86803240 @default.
- W4283394067 hasConcept C8891405 @default.
- W4283394067 hasConcept C95444343 @default.
- W4283394067 hasConceptScore W4283394067C126322002 @default.
- W4283394067 hasConceptScore W4283394067C129374314 @default.
- W4283394067 hasConceptScore W4283394067C138885662 @default.
- W4283394067 hasConceptScore W4283394067C194051981 @default.
- W4283394067 hasConceptScore W4283394067C202751555 @default.
- W4283394067 hasConceptScore W4283394067C203014093 @default.
- W4283394067 hasConceptScore W4283394067C207936829 @default.
- W4283394067 hasConceptScore W4283394067C2776090121 @default.
- W4283394067 hasConceptScore W4283394067C2778137410 @default.
- W4283394067 hasConceptScore W4283394067C2911091166 @default.
- W4283394067 hasConceptScore W4283394067C41895202 @default.
- W4283394067 hasConceptScore W4283394067C502942594 @default.
- W4283394067 hasConceptScore W4283394067C54355233 @default.
- W4283394067 hasConceptScore W4283394067C71924100 @default.
- W4283394067 hasConceptScore W4283394067C86803240 @default.
- W4283394067 hasConceptScore W4283394067C8891405 @default.
- W4283394067 hasConceptScore W4283394067C95444343 @default.
- W4283394067 hasLocation W42833940671 @default.
- W4283394067 hasLocation W42833940672 @default.
- W4283394067 hasOpenAccess W4283394067 @default.
- W4283394067 hasPrimaryLocation W42833940671 @default.
- W4283394067 hasRelatedWork W1980325666 @default.
- W4283394067 hasRelatedWork W1984741504 @default.
- W4283394067 hasRelatedWork W2368713645 @default.
- W4283394067 hasRelatedWork W2398182259 @default.
- W4283394067 hasRelatedWork W2411843333 @default.
- W4283394067 hasRelatedWork W2414417009 @default.
- W4283394067 hasRelatedWork W2418810351 @default.
- W4283394067 hasRelatedWork W2436643705 @default.
- W4283394067 hasRelatedWork W2468891481 @default.
- W4283394067 hasRelatedWork W3147194184 @default.
- W4283394067 hasVolume "248" @default.
- W4283394067 isParatext "false" @default.
- W4283394067 isRetracted "false" @default.
- W4283394067 workType "article" @default.