Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283398856> ?p ?o ?g. }
- W4283398856 abstract "The intestinal immune system and microbiota are emerging as important contributors to the development of metabolic syndrome, but the role of intestinal dendritic cells (DCs) in this context is incompletely understood. BATF3 is a transcription factor essential in the development of mucosal conventional DCs type 1 (cDC1). We show that Batf3 -/- mice developed metabolic syndrome and have altered localization of tight junction proteins in intestinal epithelial cells leading to increased intestinal permeability. Treatment with the glycolysis inhibitor 2-deoxy-D-glucose reduced intestinal inflammation and restored barrier function in obese Batf3 -/- mice. High-fat diet further enhanced the metabolic phenotype and susceptibility to dextran sulfate sodium colitis in Batf3 -/- mice. Antibiotic treatment of Batf3 -/- mice prevented metabolic syndrome and impaired intestinal barrier function. Batf3 -/- mice have altered IgA-coating of fecal bacteria and displayed microbial dysbiosis marked by decreased obesity protective Akkermansia muciniphila , and Bifidobacterium . Thus, BATF3 protects against metabolic syndrome and preserves intestinal epithelial barrier by maintaining beneficial microbiota." @default.
- W4283398856 created "2022-06-25" @default.
- W4283398856 creator A5014166303 @default.
- W4283398856 creator A5015849277 @default.
- W4283398856 creator A5017334402 @default.
- W4283398856 creator A5042050280 @default.
- W4283398856 creator A5043402239 @default.
- W4283398856 creator A5051456722 @default.
- W4283398856 creator A5054542626 @default.
- W4283398856 creator A5056750939 @default.
- W4283398856 creator A5072150935 @default.
- W4283398856 creator A5075561470 @default.
- W4283398856 creator A5086835600 @default.
- W4283398856 creator A5090468301 @default.
- W4283398856 creator A5038424108 @default.
- W4283398856 date "2022-06-22" @default.
- W4283398856 modified "2023-09-27" @default.
- W4283398856 title "BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis" @default.
- W4283398856 cites W1787214439 @default.
- W4283398856 cites W1856943231 @default.
- W4283398856 cites W1906377272 @default.
- W4283398856 cites W1928460949 @default.
- W4283398856 cites W1953103451 @default.
- W4283398856 cites W1964895626 @default.
- W4283398856 cites W1965157206 @default.
- W4283398856 cites W1967896870 @default.
- W4283398856 cites W1968458512 @default.
- W4283398856 cites W1979217507 @default.
- W4283398856 cites W2004549986 @default.
- W4283398856 cites W2011255130 @default.
- W4283398856 cites W2022837689 @default.
- W4283398856 cites W2031306149 @default.
- W4283398856 cites W2041136224 @default.
- W4283398856 cites W2042074642 @default.
- W4283398856 cites W2043221884 @default.
- W4283398856 cites W2044286043 @default.
- W4283398856 cites W2046505430 @default.
- W4283398856 cites W2049909747 @default.
- W4283398856 cites W2053039168 @default.
- W4283398856 cites W2068126966 @default.
- W4283398856 cites W2069296495 @default.
- W4283398856 cites W2080549540 @default.
- W4283398856 cites W2083089709 @default.
- W4283398856 cites W2086648828 @default.
- W4283398856 cites W2088734250 @default.
- W4283398856 cites W2090488505 @default.
- W4283398856 cites W2092760439 @default.
- W4283398856 cites W2094504570 @default.
- W4283398856 cites W2102293117 @default.
- W4283398856 cites W2104890139 @default.
- W4283398856 cites W2108449579 @default.
- W4283398856 cites W2109245089 @default.
- W4283398856 cites W2112291880 @default.
- W4283398856 cites W2113511371 @default.
- W4283398856 cites W2121908572 @default.
- W4283398856 cites W2124848390 @default.
- W4283398856 cites W2129917444 @default.
- W4283398856 cites W2131536322 @default.
- W4283398856 cites W2135139633 @default.
- W4283398856 cites W2136417551 @default.
- W4283398856 cites W2139334262 @default.
- W4283398856 cites W2142084466 @default.
- W4283398856 cites W2147790901 @default.
- W4283398856 cites W2149515881 @default.
- W4283398856 cites W2157310133 @default.
- W4283398856 cites W2160234571 @default.
- W4283398856 cites W2161702641 @default.
- W4283398856 cites W2163710303 @default.
- W4283398856 cites W2165857119 @default.
- W4283398856 cites W2167062509 @default.
- W4283398856 cites W2179438025 @default.
- W4283398856 cites W2201442248 @default.
- W4283398856 cites W2222894597 @default.
- W4283398856 cites W2272557320 @default.
- W4283398856 cites W2272642354 @default.
- W4283398856 cites W2334209689 @default.
- W4283398856 cites W2401404581 @default.
- W4283398856 cites W2434078654 @default.
- W4283398856 cites W2465534016 @default.
- W4283398856 cites W2513994159 @default.
- W4283398856 cites W2559678284 @default.
- W4283398856 cites W2579395322 @default.
- W4283398856 cites W2587727241 @default.
- W4283398856 cites W2605221354 @default.
- W4283398856 cites W2607031541 @default.
- W4283398856 cites W2727371443 @default.
- W4283398856 cites W2741982109 @default.
- W4283398856 cites W2768815597 @default.
- W4283398856 cites W2770282900 @default.
- W4283398856 cites W2787932709 @default.
- W4283398856 cites W2792106921 @default.
- W4283398856 cites W2793435470 @default.
- W4283398856 cites W2794419196 @default.
- W4283398856 cites W2803031462 @default.
- W4283398856 cites W2891210194 @default.
- W4283398856 cites W2907217687 @default.
- W4283398856 cites W2915108784 @default.
- W4283398856 cites W2920974035 @default.
- W4283398856 cites W2939969902 @default.
- W4283398856 cites W2943456337 @default.