Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283448439> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4283448439 abstract "Patients with atrial fibrillation (AF) and frailty are a considerable group in clinical practice. However, existing studies provide insufficient evidence of anticoagulation strategies for these patients. Therefore, we conducted a meta-analysis to determine the effectiveness and safety outcomes of direct oral anticoagulants (DOACs) for these patients.Randomized controlled trials or observational studies reporting the data about the DOACs and warfarin therapy among frail AF patients were included. The search was performed in the PubMed and Embase databases up to March 2022. Frailty was defined using the most widely used claims-based frailty index or the cumulative deficit model-based frailty index.A total of 4 studies involving 835,520 patients were included. Compared with warfarin, DOACs therapy reduced the risks of stroke or systemic embolism (HR = 0.79, 95%CI: 0.69-0.90), ischemic stroke (HR = 0.79, 95%CI: 0.71-0.87), hemorrhagic stroke (HR = 0.52, 95%CI: 0.35-0.76), and all-cause death (HR = 0.90, 95%CI: 0.84-0.96). In safety outcomes, DOACs was significantly associated with reduced risks of major bleeding (HR = 0.79, 95%CI: 0.64-0.97) and intracranial hemorrhage (HR = 0.58, 95%CI: 0.52-0.65) compared to warfarin, but there were no statistically differences in gastrointestinal bleeding (HR = 0.97, 95%CI: 0.73-1.29).DOACs exerted superior effectiveness and safety outcome than warfarin in AF patients with frailty." @default.
- W4283448439 created "2022-06-26" @default.
- W4283448439 creator A5005388888 @default.
- W4283448439 creator A5037156238 @default.
- W4283448439 creator A5057708781 @default.
- W4283448439 creator A5069013621 @default.
- W4283448439 creator A5087809584 @default.
- W4283448439 creator A5091511286 @default.
- W4283448439 date "2022-06-24" @default.
- W4283448439 modified "2023-09-30" @default.
- W4283448439 title "Effectiveness and Safety of DOACs vs. Warfarin in Patients With Atrial Fibrillation and Frailty: A Systematic Review and Meta-Analysis" @default.
- W4283448439 cites W2040329824 @default.
- W4283448439 cites W2096246254 @default.
- W4283448439 cites W2097854437 @default.
- W4283448439 cites W2117807413 @default.
- W4283448439 cites W2136489990 @default.
- W4283448439 cites W2140141379 @default.
- W4283448439 cites W2152623033 @default.
- W4283448439 cites W2160965212 @default.
- W4283448439 cites W2162508946 @default.
- W4283448439 cites W2291720716 @default.
- W4283448439 cites W2539102312 @default.
- W4283448439 cites W2560818339 @default.
- W4283448439 cites W2612511548 @default.
- W4283448439 cites W2796691103 @default.
- W4283448439 cites W2901264117 @default.
- W4283448439 cites W2913705661 @default.
- W4283448439 cites W2915181639 @default.
- W4283448439 cites W2921813015 @default.
- W4283448439 cites W3010540997 @default.
- W4283448439 cites W3011304812 @default.
- W4283448439 cites W3012673594 @default.
- W4283448439 cites W3038176853 @default.
- W4283448439 cites W3044639288 @default.
- W4283448439 cites W3082179368 @default.
- W4283448439 cites W3093085455 @default.
- W4283448439 cites W3108889960 @default.
- W4283448439 cites W3131084531 @default.
- W4283448439 cites W3184824800 @default.
- W4283448439 cites W4213224106 @default.
- W4283448439 doi "https://doi.org/10.3389/fcvm.2022.907197" @default.
- W4283448439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35811719" @default.
- W4283448439 hasPublicationYear "2022" @default.
- W4283448439 type Work @default.
- W4283448439 citedByCount "4" @default.
- W4283448439 countsByYear W42834484392022 @default.
- W4283448439 countsByYear W42834484392023 @default.
- W4283448439 crossrefType "journal-article" @default.
- W4283448439 hasAuthorship W4283448439A5005388888 @default.
- W4283448439 hasAuthorship W4283448439A5037156238 @default.
- W4283448439 hasAuthorship W4283448439A5057708781 @default.
- W4283448439 hasAuthorship W4283448439A5069013621 @default.
- W4283448439 hasAuthorship W4283448439A5087809584 @default.
- W4283448439 hasAuthorship W4283448439A5091511286 @default.
- W4283448439 hasBestOaLocation W42834484391 @default.
- W4283448439 hasConcept C126322002 @default.
- W4283448439 hasConcept C127413603 @default.
- W4283448439 hasConcept C164705383 @default.
- W4283448439 hasConcept C168563851 @default.
- W4283448439 hasConcept C23131810 @default.
- W4283448439 hasConcept C2776301958 @default.
- W4283448439 hasConcept C2778080469 @default.
- W4283448439 hasConcept C2779161974 @default.
- W4283448439 hasConcept C2780645631 @default.
- W4283448439 hasConcept C71924100 @default.
- W4283448439 hasConcept C78519656 @default.
- W4283448439 hasConcept C95190672 @default.
- W4283448439 hasConceptScore W4283448439C126322002 @default.
- W4283448439 hasConceptScore W4283448439C127413603 @default.
- W4283448439 hasConceptScore W4283448439C164705383 @default.
- W4283448439 hasConceptScore W4283448439C168563851 @default.
- W4283448439 hasConceptScore W4283448439C23131810 @default.
- W4283448439 hasConceptScore W4283448439C2776301958 @default.
- W4283448439 hasConceptScore W4283448439C2778080469 @default.
- W4283448439 hasConceptScore W4283448439C2779161974 @default.
- W4283448439 hasConceptScore W4283448439C2780645631 @default.
- W4283448439 hasConceptScore W4283448439C71924100 @default.
- W4283448439 hasConceptScore W4283448439C78519656 @default.
- W4283448439 hasConceptScore W4283448439C95190672 @default.
- W4283448439 hasLocation W42834484391 @default.
- W4283448439 hasLocation W42834484392 @default.
- W4283448439 hasLocation W42834484393 @default.
- W4283448439 hasOpenAccess W4283448439 @default.
- W4283448439 hasPrimaryLocation W42834484391 @default.
- W4283448439 hasRelatedWork W1983415041 @default.
- W4283448439 hasRelatedWork W2048402298 @default.
- W4283448439 hasRelatedWork W2081145557 @default.
- W4283448439 hasRelatedWork W2114223015 @default.
- W4283448439 hasRelatedWork W2157689025 @default.
- W4283448439 hasRelatedWork W2274835053 @default.
- W4283448439 hasRelatedWork W2415605004 @default.
- W4283448439 hasRelatedWork W2460869168 @default.
- W4283448439 hasRelatedWork W3151733905 @default.
- W4283448439 hasRelatedWork W3193900294 @default.
- W4283448439 hasVolume "9" @default.
- W4283448439 isParatext "false" @default.
- W4283448439 isRetracted "false" @default.
- W4283448439 workType "article" @default.