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- W4283449630 abstract "Abstract Objective To assess whether more severe urinary symptoms and poorer quality of life among patients on diuretic therapy are associated with decreased adherence to the diuretic regimen. Methods Participants were recruited via ResearchMatch.org and sent a REDCap survey. The Overactive Bladder Questionnaire‐Short Form (OAB‐q SF) was used to assess urinary symptom bother and health‐related quality of life (HRQL). Participants were asked if they skip diuretic doses due to urinary symptoms with a bivariate (yes or no) outcome. Subgroup analyses of loop vs non‐loop diuretic and those taking the diuretic for a cardiovascular indication (hypertension or heart failure) were performed. Results A total of 4029 surveys were sent, 285 were returned (7.1% response rate), and 279 were included in the study. Fifty‐three participants admitted to skipping diuretic doses due to urinary symptoms. Lower HRQL scores were significantly associated with poorer adherence scores among all participants ( P < .001), among participants taking a loop diuretic ( P < .001), and among participants with hypertension and heart failure ( P < .039). Association between symptoms and adherence remained significant after adjustment in the multivariate model for the whole cohort and loop diuretic subgroup but lost significance in the hypertension and heart failure subgroup. Conclusions Worsening quality of life due to urinary symptoms may be associated with poorer adherence to diuretics, particularly loop diuretics." @default.
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- W4283449630 date "2022-06-23" @default.
- W4283449630 modified "2023-09-27" @default.
- W4283449630 title "Association of lower urinary tract symptoms and diuretic adherence" @default.
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- W4283449630 doi "https://doi.org/10.1111/luts.12452" @default.
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