Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283451744> ?p ?o ?g. }
- W4283451744 abstract "Abstract Background Current clinical trials of new antibiotics facilitate bringing new drugs to market but often fail to provide useful information for clinical decision making. Methods Literature review of desirability of outcome ranking (DOOR) in antibiotic clinical trials and description how DOOR can fit into design, administration, and assessment of clinical trials. Results DOOR is an approach that addresses many of the shortcomings of current trials by incorporating efficacy and safety into a single outcome to analyze the patient experience in its entirety. Application of partial credit, tiebreaker strategies including response adjusted for duration of antibiotic risk (RADAR), and DOOR for Management of Antimicrobial Therapy (DOOR MAT) provides additional nuance and granularity. To address pitfalls of DOOR, investigators must develop the DOOR a priori, ideally with input from and incorporation of patient voices, and should perform component analysis to ensure that imbalances in key components are detected. Conclusion Inclusion of DOOR in clinical trials will enrich our understanding of how new antibiotics might benefit patients who have had transplantation. Additional work to develop best practices for DOOR selection, analysis, and interpretation must continue, and incorporation of the patient perspective is essential." @default.
- W4283451744 created "2022-06-26" @default.
- W4283451744 creator A5089096661 @default.
- W4283451744 creator A9999999999 @default.
- W4283451744 date "2022-10-01" @default.
- W4283451744 modified "2023-10-14" @default.
- W4283451744 title "Desirability of outcome ranking and quality life measurement for antimicrobial research in organ transplantation" @default.
- W4283451744 cites W1833960158 @default.
- W4283451744 cites W1933023737 @default.
- W4283451744 cites W1991510748 @default.
- W4283451744 cites W2002614443 @default.
- W4283451744 cites W2008010728 @default.
- W4283451744 cites W2016877893 @default.
- W4283451744 cites W2036469561 @default.
- W4283451744 cites W2069091142 @default.
- W4283451744 cites W2093413494 @default.
- W4283451744 cites W2122965425 @default.
- W4283451744 cites W2146979304 @default.
- W4283451744 cites W2147186719 @default.
- W4283451744 cites W2164963279 @default.
- W4283451744 cites W2235379620 @default.
- W4283451744 cites W2242566576 @default.
- W4283451744 cites W2289648316 @default.
- W4283451744 cites W2302118651 @default.
- W4283451744 cites W2401547988 @default.
- W4283451744 cites W2406039484 @default.
- W4283451744 cites W2418190818 @default.
- W4283451744 cites W2494153709 @default.
- W4283451744 cites W2548889063 @default.
- W4283451744 cites W2560710930 @default.
- W4283451744 cites W2613519430 @default.
- W4283451744 cites W2746236897 @default.
- W4283451744 cites W2747141653 @default.
- W4283451744 cites W2766370714 @default.
- W4283451744 cites W2788452108 @default.
- W4283451744 cites W2896665945 @default.
- W4283451744 cites W2903050558 @default.
- W4283451744 cites W2910108794 @default.
- W4283451744 cites W2921585119 @default.
- W4283451744 cites W2952985760 @default.
- W4283451744 cites W2967609007 @default.
- W4283451744 cites W2999711299 @default.
- W4283451744 cites W3027529392 @default.
- W4283451744 cites W3108322928 @default.
- W4283451744 cites W3137306323 @default.
- W4283451744 cites W3160485181 @default.
- W4283451744 cites W3179787941 @default.
- W4283451744 cites W3198781200 @default.
- W4283451744 cites W3206537156 @default.
- W4283451744 cites W4200197744 @default.
- W4283451744 cites W4205658511 @default.
- W4283451744 cites W4206234526 @default.
- W4283451744 cites W4226147252 @default.
- W4283451744 cites W4243654148 @default.
- W4283451744 cites W57243186 @default.
- W4283451744 cites W3136497559 @default.
- W4283451744 doi "https://doi.org/10.1111/tid.13888" @default.
- W4283451744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35748640" @default.
- W4283451744 hasPublicationYear "2022" @default.
- W4283451744 type Work @default.
- W4283451744 citedByCount "5" @default.
- W4283451744 countsByYear W42834517442022 @default.
- W4283451744 countsByYear W42834517442023 @default.
- W4283451744 crossrefType "journal-article" @default.
- W4283451744 hasAuthorship W4283451744A5089096661 @default.
- W4283451744 hasAuthorship W4283451744A9999999999 @default.
- W4283451744 hasBestOaLocation W42834517442 @default.
- W4283451744 hasConcept C112930515 @default.
- W4283451744 hasConcept C141071460 @default.
- W4283451744 hasConcept C142724271 @default.
- W4283451744 hasConcept C144237770 @default.
- W4283451744 hasConcept C148220186 @default.
- W4283451744 hasConcept C148482608 @default.
- W4283451744 hasConcept C154945302 @default.
- W4283451744 hasConcept C177713679 @default.
- W4283451744 hasConcept C189430467 @default.
- W4283451744 hasConcept C19527891 @default.
- W4283451744 hasConcept C2911091166 @default.
- W4283451744 hasConcept C33923547 @default.
- W4283451744 hasConcept C41008148 @default.
- W4283451744 hasConcept C535046627 @default.
- W4283451744 hasConcept C71924100 @default.
- W4283451744 hasConceptScore W4283451744C112930515 @default.
- W4283451744 hasConceptScore W4283451744C141071460 @default.
- W4283451744 hasConceptScore W4283451744C142724271 @default.
- W4283451744 hasConceptScore W4283451744C144237770 @default.
- W4283451744 hasConceptScore W4283451744C148220186 @default.
- W4283451744 hasConceptScore W4283451744C148482608 @default.
- W4283451744 hasConceptScore W4283451744C154945302 @default.
- W4283451744 hasConceptScore W4283451744C177713679 @default.
- W4283451744 hasConceptScore W4283451744C189430467 @default.
- W4283451744 hasConceptScore W4283451744C19527891 @default.
- W4283451744 hasConceptScore W4283451744C2911091166 @default.
- W4283451744 hasConceptScore W4283451744C33923547 @default.
- W4283451744 hasConceptScore W4283451744C41008148 @default.
- W4283451744 hasConceptScore W4283451744C535046627 @default.
- W4283451744 hasConceptScore W4283451744C71924100 @default.
- W4283451744 hasIssue "5" @default.
- W4283451744 hasLocation W42834517441 @default.
- W4283451744 hasLocation W42834517442 @default.