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- W4283460235 abstract "The analysis and separation of chiral compounds with wide polar range by supercritical fluid chromatography is of major importance in the process of drug development and quality control. In this work, a fast and reliable enantioselective method for the simultaneous quantitative determination of 8 DBZ-related enantiomers has been successfully developed by supercritical fluid chromatography using an amylose-based reversed-chiral stationary phase. Within less than seven minutes all target compounds could be baseline resolved, using a mobile phase comprising supercritical carbon dioxide and methanol with 0.05 % H3PO4. The optimum chiral stationary phase showed to be a CHIRALPAK® AD-RH column, operated at flow rate of 3.0 mL/min, back pressure of 150 bar and temperature of 40 °C. Method validation confirmed that the developed procedure was selective, linear (r2 > 0.998), accurate (recovery rates: 98.02-100.02 %), and precise (intra-day: 0.05-1.98 %, inter-day: 0.08-1.98 %); the limit of detection and limit of quantification were 0.13-0.55 μg/mL and 0.37-1.68 μg/mL on column, respectively. After initial evaluation of stability according to the ICH Q1A (R2) guideline, R-DBZ showed good stability. Thus, this developed method can be used for assessing the stability of bulk DBZ samples, dosage forms of DBZ and also for monitoring the synthetic procedures of DBZ." @default.
- W4283460235 created "2022-06-26" @default.
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- W4283460235 date "2022-09-01" @default.
- W4283460235 modified "2023-10-18" @default.
- W4283460235 title "Simultaneous and rapid analysis of chiral Danshensu and its ester derivatives by supercritical fluid chromatography" @default.
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- W4283460235 doi "https://doi.org/10.1016/j.jpba.2022.114884" @default.
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