Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283511905> ?p ?o ?g. }
- W4283511905 endingPage "7055" @default.
- W4283511905 startingPage "7055" @default.
- W4283511905 abstract "Metastatic progression of female breast and colon cancer represents a major cause of mortality in women. Spontaneous/acquired resistance to conventional and targeted chemo-endocrine therapy is associated with the emergence of drug-resistant tumor-initiating cancer stem cell populations. The cancer-initiating premalignant stem cells exhibit activation of select cancer cell signaling pathways and undergo epithelial-mesenchymal transition, leading to the evolution of a metastatic phenotype. The development of reliable cancer stem cell models provides valuable experimental approaches to identify novel testable therapeutic alternatives for therapy-resistant cancer. Drug-resistant stem cell models for molecular subtypes of clinical breast cancer and for genetically predisposed colon cancer are developed by selecting epithelial cells that survive in the presence of cytostatic concentrations of relevant therapeutic agents. These putative stem cells are characterized by the expression status of select cellular and molecular stem cell markers. The stem cell models are utilized as experimental approaches to examine the stem-cell-targeted growth inhibitory efficacy of naturally occurring dietary phytochemicals. The present review provides a systematic discussion on (i) conceptual and experimental aspects relevant to the chemo-endocrine therapy of breast and colon cancer, (ii) molecular/cellular aspects of cancer stem cells and (iii) potential stem-cell-targeting lead compounds as testable alternatives against the progression of therapy-resistant breast and colon cancer." @default.
- W4283511905 created "2022-06-27" @default.
- W4283511905 creator A5013105207 @default.
- W4283511905 date "2022-06-24" @default.
- W4283511905 modified "2023-09-30" @default.
- W4283511905 title "Stem Cell Models for Cancer Therapy" @default.
- W4283511905 cites W1518290383 @default.
- W4283511905 cites W1942826257 @default.
- W4283511905 cites W1960988927 @default.
- W4283511905 cites W1968016219 @default.
- W4283511905 cites W1981068608 @default.
- W4283511905 cites W1992907433 @default.
- W4283511905 cites W2002179012 @default.
- W4283511905 cites W2003685376 @default.
- W4283511905 cites W2016965610 @default.
- W4283511905 cites W2024905084 @default.
- W4283511905 cites W2048863570 @default.
- W4283511905 cites W2055860719 @default.
- W4283511905 cites W2062069198 @default.
- W4283511905 cites W2066091675 @default.
- W4283511905 cites W2068991040 @default.
- W4283511905 cites W2072239613 @default.
- W4283511905 cites W2091340779 @default.
- W4283511905 cites W2113861056 @default.
- W4283511905 cites W2115876798 @default.
- W4283511905 cites W2121454015 @default.
- W4283511905 cites W2124254475 @default.
- W4283511905 cites W2147631083 @default.
- W4283511905 cites W2160260402 @default.
- W4283511905 cites W2210107480 @default.
- W4283511905 cites W2400130046 @default.
- W4283511905 cites W2411018709 @default.
- W4283511905 cites W2518696212 @default.
- W4283511905 cites W2524678731 @default.
- W4283511905 cites W2570331431 @default.
- W4283511905 cites W2588464939 @default.
- W4283511905 cites W2594873390 @default.
- W4283511905 cites W2606001457 @default.
- W4283511905 cites W2684461861 @default.
- W4283511905 cites W2727543929 @default.
- W4283511905 cites W2773981699 @default.
- W4283511905 cites W2783721414 @default.
- W4283511905 cites W2799444748 @default.
- W4283511905 cites W2891589486 @default.
- W4283511905 cites W2903713666 @default.
- W4283511905 cites W2922915032 @default.
- W4283511905 cites W2945824904 @default.
- W4283511905 cites W2993842426 @default.
- W4283511905 cites W3003869816 @default.
- W4283511905 cites W3007609761 @default.
- W4283511905 cites W3033283476 @default.
- W4283511905 cites W3036971190 @default.
- W4283511905 cites W3042463417 @default.
- W4283511905 cites W3049036781 @default.
- W4283511905 cites W3080902257 @default.
- W4283511905 cites W3081189407 @default.
- W4283511905 cites W3103250275 @default.
- W4283511905 cites W3108709169 @default.
- W4283511905 cites W3134514037 @default.
- W4283511905 cites W3177355797 @default.
- W4283511905 cites W3179340353 @default.
- W4283511905 cites W3180741009 @default.
- W4283511905 cites W3195505313 @default.
- W4283511905 cites W3216694249 @default.
- W4283511905 cites W4200220719 @default.
- W4283511905 cites W4206960774 @default.
- W4283511905 cites W4211219914 @default.
- W4283511905 cites W4214492936 @default.
- W4283511905 cites W4220652528 @default.
- W4283511905 cites W4220824836 @default.
- W4283511905 cites W4221019023 @default.
- W4283511905 cites W4225154128 @default.
- W4283511905 cites W4225269156 @default.
- W4283511905 cites W4225349255 @default.
- W4283511905 cites W4226368127 @default.
- W4283511905 doi "https://doi.org/10.3390/ijms23137055" @default.
- W4283511905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35806056" @default.
- W4283511905 hasPublicationYear "2022" @default.
- W4283511905 type Work @default.
- W4283511905 citedByCount "5" @default.
- W4283511905 countsByYear W42835119052022 @default.
- W4283511905 countsByYear W42835119052023 @default.
- W4283511905 crossrefType "journal-article" @default.
- W4283511905 hasAuthorship W4283511905A5013105207 @default.
- W4283511905 hasBestOaLocation W42835119051 @default.
- W4283511905 hasConcept C121608353 @default.
- W4283511905 hasConcept C126322002 @default.
- W4283511905 hasConcept C2775930923 @default.
- W4283511905 hasConcept C2779013556 @default.
- W4283511905 hasConcept C2781230642 @default.
- W4283511905 hasConcept C28328180 @default.
- W4283511905 hasConcept C502942594 @default.
- W4283511905 hasConcept C526805850 @default.
- W4283511905 hasConcept C530470458 @default.
- W4283511905 hasConcept C55427017 @default.
- W4283511905 hasConcept C71924100 @default.
- W4283511905 hasConcept C76419328 @default.
- W4283511905 hasConcept C86803240 @default.