FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283513772> ?p ?o ?g. }

• W4283513772 endingPage "566" @default.
• W4283513772 startingPage "559" @default.
• W4283513772 abstract "Several natural products are known to have anticancer activity, which helps prevent cancer. This study explores the potential use of different extracts of Annona muricata L. and Antidesma bunius L. leaves as an anticancer drug by testing its anti-oxidative and anticancer properties. Furthermore, metabolomics of these plant extracts was performed to characterize them. This project studied the bioactivities and phytochemistry of plants found in Mt. Makiling, Philippines. Hexane, ethyl acetate, and methanol leaf extracts of Annona muricata L. (Guyabano) and Antidesma bunius L. (Bignay) were screened for their anticancer and antioxidant properties. Extracts of each plant species were subjected to a clean-up procedure (removal of tannins and chlorophyll) and were analyzed using the same tests as the crude. The growth inhibitory effect against A-549 human lung carcinoma cells was determined using MTT assay, while the total antioxidant activity was determined using DPPH assay. All extracts exhibited both anticancer and antioxidant activity of varying degrees. Ethyl acetate crude extract of Annona muricata L. showed the highest percent growth inhibition against lung cancer cells, while methanol crude extract of Antidesma bunius L. showed the highest total antioxidant activity. The effect of the clean-up procedure varied per extract; some exhibited an enhanced activity while others exhibited a decreased activity upon clean-up. The extracts’ responses to free radicals and lung cancer cells can be attributed to phytochemicals like alkaloids, indoles, and phenols identified using qualitative phytochemical tests and LC-MS/MS analysis. Results suggest that Annona muricata L. and Antidesma bunius L. leaf extracts are potential anticancer and antioxidant agents." @default.
• W4283513772 created "2022-06-27" @default.
• W4283513772 creator A5004834354 @default.
• W4283513772 creator A5007281914 @default.
• W4283513772 creator A5009540751 @default.
• W4283513772 creator A5011101735 @default.
• W4283513772 creator A5015151166 @default.
• W4283513772 creator A5015853906 @default.
• W4283513772 creator A5017676356 @default.
• W4283513772 creator A5018961741 @default.
• W4283513772 creator A5021313018 @default.
• W4283513772 creator A5029480282 @default.
• W4283513772 creator A5049353015 @default.
• W4283513772 creator A5063006981 @default.
• W4283513772 creator A5075502508 @default.
• W4283513772 creator A5083501328 @default.
• W4283513772 date "2022-12-01" @default.
• W4283513772 modified "2023-10-07" @default.
• W4283513772 title "Antioxidant and anticancer activities of Annona muricata L. and Antidesma bunius L. leaves, and molecular networking analysis using LC-MS/MS metabolomics" @default.
• W4283513772 cites W1534849470 @default.
• W4283513772 cites W1968582344 @default.
• W4283513772 cites W1981390981 @default.
• W4283513772 cites W1983150601 @default.
• W4283513772 cites W1993030960 @default.
• W4283513772 cites W2051875642 @default.
• W4283513772 cites W2108504202 @default.
• W4283513772 cites W2130810241 @default.
• W4283513772 cites W2134622335 @default.
• W4283513772 cites W2167141095 @default.
• W4283513772 cites W2170615088 @default.
• W4283513772 cites W2256742438 @default.
• W4283513772 cites W2415836684 @default.
• W4283513772 cites W2557544119 @default.
• W4283513772 cites W2783254479 @default.
• W4283513772 cites W2898273716 @default.
• W4283513772 cites W2966383960 @default.
• W4283513772 cites W3022840335 @default.
• W4283513772 cites W3025883815 @default.
• W4283513772 cites W3163842294 @default.
• W4283513772 doi "https://doi.org/10.1016/j.sajb.2022.06.019" @default.
• W4283513772 hasPublicationYear "2022" @default.
• W4283513772 type Work @default.
• W4283513772 citedByCount "3" @default.
• W4283513772 countsByYear W42835137722023 @default.
• W4283513772 crossrefType "journal-article" @default.
• W4283513772 hasAuthorship W4283513772A5004834354 @default.
• W4283513772 hasAuthorship W4283513772A5007281914 @default.
• W4283513772 hasAuthorship W4283513772A5009540751 @default.
• W4283513772 hasAuthorship W4283513772A5011101735 @default.
• W4283513772 hasAuthorship W4283513772A5015151166 @default.
• W4283513772 hasAuthorship W4283513772A5015853906 @default.
• W4283513772 hasAuthorship W4283513772A5017676356 @default.
• W4283513772 hasAuthorship W4283513772A5018961741 @default.
• W4283513772 hasAuthorship W4283513772A5021313018 @default.
• W4283513772 hasAuthorship W4283513772A5029480282 @default.
• W4283513772 hasAuthorship W4283513772A5049353015 @default.
• W4283513772 hasAuthorship W4283513772A5063006981 @default.
• W4283513772 hasAuthorship W4283513772A5075502508 @default.
• W4283513772 hasAuthorship W4283513772A5083501328 @default.
• W4283513772 hasConcept C185592680 @default.
• W4283513772 hasConcept C195475562 @default.
• W4283513772 hasConcept C2778004101 @default.
• W4283513772 hasConcept C2779565439 @default.
• W4283513772 hasConcept C2779858419 @default.
• W4283513772 hasConcept C2780230357 @default.
• W4283513772 hasConcept C2780303139 @default.
• W4283513772 hasConcept C2780783641 @default.
• W4283513772 hasConcept C2781401929 @default.
• W4283513772 hasConcept C523307889 @default.
• W4283513772 hasConcept C55493867 @default.
• W4283513772 hasConcept C556039675 @default.
• W4283513772 hasConcept C59822182 @default.
• W4283513772 hasConcept C62112901 @default.
• W4283513772 hasConcept C71924100 @default.
• W4283513772 hasConcept C86803240 @default.
• W4283513772 hasConceptScore W4283513772C185592680 @default.
• W4283513772 hasConceptScore W4283513772C195475562 @default.
• W4283513772 hasConceptScore W4283513772C2778004101 @default.
• W4283513772 hasConceptScore W4283513772C2779565439 @default.
• W4283513772 hasConceptScore W4283513772C2779858419 @default.
• W4283513772 hasConceptScore W4283513772C2780230357 @default.
• W4283513772 hasConceptScore W4283513772C2780303139 @default.
• W4283513772 hasConceptScore W4283513772C2780783641 @default.
• W4283513772 hasConceptScore W4283513772C2781401929 @default.
• W4283513772 hasConceptScore W4283513772C523307889 @default.
• W4283513772 hasConceptScore W4283513772C55493867 @default.
• W4283513772 hasConceptScore W4283513772C556039675 @default.
• W4283513772 hasConceptScore W4283513772C59822182 @default.
• W4283513772 hasConceptScore W4283513772C62112901 @default.
• W4283513772 hasConceptScore W4283513772C71924100 @default.
• W4283513772 hasConceptScore W4283513772C86803240 @default.
• W4283513772 hasFunder F4320324072 @default.
• W4283513772 hasLocation W42835137721 @default.
• W4283513772 hasOpenAccess W4283513772 @default.
• W4283513772 hasPrimaryLocation W42835137721 @default.
• W4283513772 hasRelatedWork W1996050923 @default.
• W4283513772 hasRelatedWork W2069006262 @default.
• W4283513772 hasRelatedWork W2069803233 @default.

• next