FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283516296> ?p ?o ?g. }

• W4283516296 endingPage "113307" @default.
• W4283516296 startingPage "113307" @default.
• W4283516296 abstract "Systemic chronic inflammation and immune dysfunction are recognized as drivers of the development of non-AIDS related comorbidities (NARCs) in people living with HIV (PLHIV). In order to lower the risk of NARCs, it is critical to elucidate what is the contribution of alterations in the composition and function of circulating immune cells to NARCs-related pathogenesis. Findings from previous immunophenotyping studies in PLHIV are highly heterogeneous and it is not fully understood to what extent phenotypic changes on immune cells play a role in the dysregulated inflammatory response observed. In this study, three flow cytometry panels were designed and standardized to phenotypically and functionally identify the main circulating immune cell subsets in PLHIV. To reduce variability, up to 10 markers out of the approximately 20 markers in each panel were used in a custom dry format DURA Innovations (LUCID product line). Intra-assay precision tests performed for the selected cell subsets showed that the three panels had a %CV below 18% for percent of positive cells and the MFI (mean fluorescent intensity) of lineage markers. Our reported pipeline for immunophenotypic analysis facilitated the discrimination of 1153 cell populations, providing an integrated overview of circulating innate and adaptative immune cells as well as the cells’ functional status in terms of activation, exhaustion, and maturation. When combined with unsupervised computational techniques, this standardized immunophenotyping approach may support the discovery of novel phenotypes with clinical relevance in NARCs and demonstrate future utility in other immune-mediated diseases." @default.
• W4283516296 created "2022-06-27" @default.
• W4283516296 creator A5016367609 @default.
• W4283516296 creator A5027955775 @default.
• W4283516296 creator A5028653276 @default.
• W4283516296 creator A5036752858 @default.
• W4283516296 creator A5041101723 @default.
• W4283516296 creator A5044137556 @default.
• W4283516296 creator A5051884470 @default.
• W4283516296 creator A5060026610 @default.
• W4283516296 creator A5069848230 @default.
• W4283516296 creator A5074475221 @default.
• W4283516296 creator A5077251334 @default.
• W4283516296 creator A5085456112 @default.
• W4283516296 creator A5087918170 @default.
• W4283516296 date "2022-08-01" @default.
• W4283516296 modified "2023-09-26" @default.
• W4283516296 title "Comprehensive phenotyping of circulating immune cell subsets in people living with HIV" @default.
• W4283516296 cites W1497374306 @default.
• W4283516296 cites W1517417834 @default.
• W4283516296 cites W1591218464 @default.
• W4283516296 cites W1978436252 @default.
• W4283516296 cites W2046682570 @default.
• W4283516296 cites W2084669174 @default.
• W4283516296 cites W2125377515 @default.
• W4283516296 cites W2143814503 @default.
• W4283516296 cites W2396754576 @default.
• W4283516296 cites W2519879971 @default.
• W4283516296 cites W2531567355 @default.
• W4283516296 cites W2680135673 @default.
• W4283516296 cites W2729696636 @default.
• W4283516296 cites W2735379097 @default.
• W4283516296 cites W2761099324 @default.
• W4283516296 cites W2765222136 @default.
• W4283516296 cites W2778617887 @default.
• W4283516296 cites W2801530722 @default.
• W4283516296 cites W2804786344 @default.
• W4283516296 cites W2889267794 @default.
• W4283516296 cites W2898798493 @default.
• W4283516296 cites W2911865233 @default.
• W4283516296 cites W2918530812 @default.
• W4283516296 cites W2945529854 @default.
• W4283516296 cites W2951919130 @default.
• W4283516296 cites W2964243955 @default.
• W4283516296 cites W3009633745 @default.
• W4283516296 cites W3048533612 @default.
• W4283516296 cites W3084543913 @default.
• W4283516296 cites W3089586631 @default.
• W4283516296 cites W3155447322 @default.
• W4283516296 cites W3206049488 @default.
• W4283516296 cites W3145897969 @default.
• W4283516296 doi "https://doi.org/10.1016/j.jim.2022.113307" @default.
• W4283516296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35760096" @default.
• W4283516296 hasPublicationYear "2022" @default.
• W4283516296 type Work @default.
• W4283516296 citedByCount "0" @default.
• W4283516296 crossrefType "journal-article" @default.
• W4283516296 hasAuthorship W4283516296A5016367609 @default.
• W4283516296 hasAuthorship W4283516296A5027955775 @default.
• W4283516296 hasAuthorship W4283516296A5028653276 @default.
• W4283516296 hasAuthorship W4283516296A5036752858 @default.
• W4283516296 hasAuthorship W4283516296A5041101723 @default.
• W4283516296 hasAuthorship W4283516296A5044137556 @default.
• W4283516296 hasAuthorship W4283516296A5051884470 @default.
• W4283516296 hasAuthorship W4283516296A5060026610 @default.
• W4283516296 hasAuthorship W4283516296A5069848230 @default.
• W4283516296 hasAuthorship W4283516296A5074475221 @default.
• W4283516296 hasAuthorship W4283516296A5077251334 @default.
• W4283516296 hasAuthorship W4283516296A5085456112 @default.
• W4283516296 hasAuthorship W4283516296A5087918170 @default.
• W4283516296 hasBestOaLocation W42835162961 @default.
• W4283516296 hasConcept C104317684 @default.
• W4283516296 hasConcept C127716648 @default.
• W4283516296 hasConcept C136449434 @default.
• W4283516296 hasConcept C196166836 @default.
• W4283516296 hasConcept C203014093 @default.
• W4283516296 hasConcept C2776914184 @default.
• W4283516296 hasConcept C54355233 @default.
• W4283516296 hasConcept C553184892 @default.
• W4283516296 hasConcept C86803240 @default.
• W4283516296 hasConcept C8891405 @default.
• W4283516296 hasConceptScore W4283516296C104317684 @default.
• W4283516296 hasConceptScore W4283516296C127716648 @default.
• W4283516296 hasConceptScore W4283516296C136449434 @default.
• W4283516296 hasConceptScore W4283516296C196166836 @default.
• W4283516296 hasConceptScore W4283516296C203014093 @default.
• W4283516296 hasConceptScore W4283516296C2776914184 @default.
• W4283516296 hasConceptScore W4283516296C54355233 @default.
• W4283516296 hasConceptScore W4283516296C553184892 @default.
• W4283516296 hasConceptScore W4283516296C86803240 @default.
• W4283516296 hasConceptScore W4283516296C8891405 @default.
• W4283516296 hasLocation W42835162961 @default.
• W4283516296 hasLocation W42835162962 @default.
• W4283516296 hasLocation W42835162963 @default.
• W4283516296 hasLocation W42835162964 @default.
• W4283516296 hasOpenAccess W4283516296 @default.
• W4283516296 hasPrimaryLocation W42835162961 @default.
• W4283516296 hasRelatedWork W1497338467 @default.

• next