Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283519889> ?p ?o ?g. }
- W4283519889 endingPage "460" @default.
- W4283519889 startingPage "449" @default.
- W4283519889 abstract "The characterization of asymptomatic and mildly symptomatic patients with COVID-19 by observing changes in gene expression profile and possible bacterial coinfection is relevant to be investigated. We aimed to identify transcriptomic and coinfection profiles in both groups of patients.A ribonucleic acid (RNA) sequence analysis on nasopharyngeal swabs were performed using a shotgun sequencing pipeline. Differential gene analysis, viral genome assembly, and metagenomics analysis were further performed using the retrieved data.Both groups of patients underwent a cilia modification and mRNA splicing. Modulations in macroautophagy, epigenetics, and cell cycle processes were observed specifically in the asymptomatic group. Modulation in the RNA transport was found specifically in the mildly symptomatic group. The mildly symptomatic group showed modulation in the RNA transport and upregulation of autophagy regulator genes and genes in the complement system. No link between viral variants and disease severity was found. Microbiome analysis revealed the elevation of Streptococcus pneumoniae and Veillonella parvula proportion in symptomatic patients.A reduction in the autophagy influx and modification in the epigenetic profile might be involved in halting the disease progression. A global dysregulation of RNA processing and translation might cause more severe outcomes in symptomatic individuals. Coinfection by opportunistic microflora should be taken into account when assessing the possible outcome of SARS-CoV-2 infection." @default.
- W4283519889 created "2022-06-27" @default.
- W4283519889 creator A5001162715 @default.
- W4283519889 creator A5002783667 @default.
- W4283519889 creator A5003132434 @default.
- W4283519889 creator A5020265856 @default.
- W4283519889 creator A5028064683 @default.
- W4283519889 creator A5029271558 @default.
- W4283519889 creator A5036675448 @default.
- W4283519889 creator A5048833322 @default.
- W4283519889 creator A5054114041 @default.
- W4283519889 creator A5068810623 @default.
- W4283519889 creator A5074700090 @default.
- W4283519889 creator A5083264649 @default.
- W4283519889 date "2022-09-01" @default.
- W4283519889 modified "2023-09-26" @default.
- W4283519889 title "RNA sequence analysis of nasopharyngeal swabs from asymptomatic and mildly symptomatic patients with COVID-19" @default.
- W4283519889 cites W1523693806 @default.
- W4283519889 cites W1978005853 @default.
- W4283519889 cites W1984742686 @default.
- W4283519889 cites W1985360059 @default.
- W4283519889 cites W1991105254 @default.
- W4283519889 cites W1991823556 @default.
- W4283519889 cites W2009399048 @default.
- W4283519889 cites W2016283787 @default.
- W4283519889 cites W2024344716 @default.
- W4283519889 cites W2035618305 @default.
- W4283519889 cites W2050916209 @default.
- W4283519889 cites W2051881782 @default.
- W4283519889 cites W2069153851 @default.
- W4283519889 cites W2070730673 @default.
- W4283519889 cites W2074397923 @default.
- W4283519889 cites W2103208261 @default.
- W4283519889 cites W2137293540 @default.
- W4283519889 cites W2159954944 @default.
- W4283519889 cites W2169448470 @default.
- W4283519889 cites W2179438025 @default.
- W4283519889 cites W2558713280 @default.
- W4283519889 cites W2588878466 @default.
- W4283519889 cites W2740811199 @default.
- W4283519889 cites W2749644107 @default.
- W4283519889 cites W2794519236 @default.
- W4283519889 cites W2803007323 @default.
- W4283519889 cites W2888094294 @default.
- W4283519889 cites W2898486687 @default.
- W4283519889 cites W2903102808 @default.
- W4283519889 cites W2990618091 @default.
- W4283519889 cites W3006961006 @default.
- W4283519889 cites W3011134208 @default.
- W4283519889 cites W3011176674 @default.
- W4283519889 cites W3015010920 @default.
- W4283519889 cites W3016955027 @default.
- W4283519889 cites W3025063365 @default.
- W4283519889 cites W3027854290 @default.
- W4283519889 cites W3027964178 @default.
- W4283519889 cites W3028801636 @default.
- W4283519889 cites W3034593359 @default.
- W4283519889 cites W3035539152 @default.
- W4283519889 cites W3036101703 @default.
- W4283519889 cites W3045019589 @default.
- W4283519889 cites W3047439400 @default.
- W4283519889 cites W3084149299 @default.
- W4283519889 cites W3085326737 @default.
- W4283519889 cites W3087640434 @default.
- W4283519889 cites W3089152013 @default.
- W4283519889 cites W3089310389 @default.
- W4283519889 cites W3092296275 @default.
- W4283519889 cites W3093214735 @default.
- W4283519889 cites W3093768302 @default.
- W4283519889 cites W3097465023 @default.
- W4283519889 cites W3104298438 @default.
- W4283519889 cites W3110924399 @default.
- W4283519889 cites W3112243112 @default.
- W4283519889 cites W3112688552 @default.
- W4283519889 cites W3119007761 @default.
- W4283519889 cites W3119365546 @default.
- W4283519889 cites W3120046290 @default.
- W4283519889 cites W3120389648 @default.
- W4283519889 cites W3123118461 @default.
- W4283519889 cites W3126238650 @default.
- W4283519889 cites W3128430125 @default.
- W4283519889 cites W3129370137 @default.
- W4283519889 cites W3136213418 @default.
- W4283519889 cites W3137798530 @default.
- W4283519889 cites W3140148680 @default.
- W4283519889 cites W3154763189 @default.
- W4283519889 cites W3157881218 @default.
- W4283519889 cites W3159709594 @default.
- W4283519889 cites W3160295311 @default.
- W4283519889 cites W3160788382 @default.
- W4283519889 cites W3162132240 @default.
- W4283519889 cites W3165838540 @default.
- W4283519889 cites W3178565761 @default.
- W4283519889 cites W3193028916 @default.
- W4283519889 cites W3217582582 @default.
- W4283519889 cites W4254687493 @default.
- W4283519889 cites W4280575755 @default.
- W4283519889 cites W567741560 @default.