Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283522590> ?p ?o ?g. }
- W4283522590 endingPage "105381" @default.
- W4283522590 startingPage "105381" @default.
- W4283522590 abstract "The goal of this study was to identify cocktails of drugs able to protect cultured rodent cortical neurons against increasing durations of oxygen-glucose deprivation (OGD). As expected, a cocktail composed of an NMDA and AMPA receptor antagonists and a voltage gated Ca2+ channel blocker (MK-801, CNQX and nifedipine, respectively) provided complete neuroprotection against mild OGD. Increasingly longer durations of OGD necessitated increasing the doses of MK-801 and CNQX, until these cocktails ultimately failed to provide neuroprotection against supra-lethal OGD, even at maximal drug concentrations. Surprisingly, supplementation of any of these cocktails with blockers of TRPM7 channels for increasing OGD durations was not neuroprotective, unless these blockers possessed the ability to inhibit NMDA receptors. Supplementation of the maximally effective cocktail with other NMDA receptor antagonists augmented neuroprotection, suggesting insufficient NMDAR blockade by MK-801. Substitution of MK-801 in cocktails with high concentrations of a glycine site NMDA receptor antagonist caused the greatest improvements in neuroprotection, with the more potent SM-31900 superior to L689,560. Substitution of CQNX in cocktails with AMPA receptor antagonists at high concentrations also improved neuroprotection, particularly with the combination of SYM2206 and NBQX. The most neuroprotective cocktail was thus composed of SM-31900, SYM2206, NBQX, nifedipine and the antioxidant trolox. Thus, the cumulative properties of antagonist potency and concentration in a cocktail dictate neuroprotective efficacy. The central target of supra-lethal OGD is excitotoxicity, which must be blocked to the greatest extent possible to minimize ion influx." @default.
- W4283522590 created "2022-06-27" @default.
- W4283522590 creator A5013504280 @default.
- W4283522590 creator A5021443355 @default.
- W4283522590 creator A5024016897 @default.
- W4283522590 creator A5078746842 @default.
- W4283522590 date "2022-09-01" @default.
- W4283522590 modified "2023-10-05" @default.
- W4283522590 title "Neuroprotection against supra-lethal ‘stroke in a dish’ insults by an anti-excitotoxic receptor antagonist cocktail" @default.
- W4283522590 cites W1533853049 @default.
- W4283522590 cites W1570138648 @default.
- W4283522590 cites W1578237109 @default.
- W4283522590 cites W1600903666 @default.
- W4283522590 cites W1736438648 @default.
- W4283522590 cites W1926494419 @default.
- W4283522590 cites W1933207236 @default.
- W4283522590 cites W1964870631 @default.
- W4283522590 cites W1967476518 @default.
- W4283522590 cites W1974262918 @default.
- W4283522590 cites W1974557676 @default.
- W4283522590 cites W1976495888 @default.
- W4283522590 cites W1978507389 @default.
- W4283522590 cites W1979875015 @default.
- W4283522590 cites W1980999844 @default.
- W4283522590 cites W1983038423 @default.
- W4283522590 cites W1983407126 @default.
- W4283522590 cites W1986996789 @default.
- W4283522590 cites W1988726352 @default.
- W4283522590 cites W1993385893 @default.
- W4283522590 cites W1994638214 @default.
- W4283522590 cites W1995256270 @default.
- W4283522590 cites W1997808089 @default.
- W4283522590 cites W1998846464 @default.
- W4283522590 cites W1999612879 @default.
- W4283522590 cites W2004279893 @default.
- W4283522590 cites W2009213290 @default.
- W4283522590 cites W2010778357 @default.
- W4283522590 cites W2011851536 @default.
- W4283522590 cites W2012726689 @default.
- W4283522590 cites W2012937732 @default.
- W4283522590 cites W2016040804 @default.
- W4283522590 cites W2016640140 @default.
- W4283522590 cites W2017774678 @default.
- W4283522590 cites W2019047748 @default.
- W4283522590 cites W2022121838 @default.
- W4283522590 cites W2022770324 @default.
- W4283522590 cites W2022860532 @default.
- W4283522590 cites W2024085735 @default.
- W4283522590 cites W2025576506 @default.
- W4283522590 cites W2028079848 @default.
- W4283522590 cites W2029049747 @default.
- W4283522590 cites W2029820475 @default.
- W4283522590 cites W2031796931 @default.
- W4283522590 cites W2033275198 @default.
- W4283522590 cites W2036291450 @default.
- W4283522590 cites W2037013242 @default.
- W4283522590 cites W2039804718 @default.
- W4283522590 cites W2040276142 @default.
- W4283522590 cites W2043133738 @default.
- W4283522590 cites W2047060866 @default.
- W4283522590 cites W2048011585 @default.
- W4283522590 cites W2048307198 @default.
- W4283522590 cites W2052875832 @default.
- W4283522590 cites W2057537207 @default.
- W4283522590 cites W2057675216 @default.
- W4283522590 cites W2060779484 @default.
- W4283522590 cites W2063536602 @default.
- W4283522590 cites W2065171486 @default.
- W4283522590 cites W2065636160 @default.
- W4283522590 cites W2066581734 @default.
- W4283522590 cites W2066690328 @default.
- W4283522590 cites W2068088938 @default.
- W4283522590 cites W2069524293 @default.
- W4283522590 cites W2071452513 @default.
- W4283522590 cites W2073270857 @default.
- W4283522590 cites W2079233186 @default.
- W4283522590 cites W2079334587 @default.
- W4283522590 cites W2082205679 @default.
- W4283522590 cites W2082249282 @default.
- W4283522590 cites W2083061866 @default.
- W4283522590 cites W2088192068 @default.
- W4283522590 cites W2091837097 @default.
- W4283522590 cites W2095358033 @default.
- W4283522590 cites W2096795369 @default.
- W4283522590 cites W2096821918 @default.
- W4283522590 cites W2101308371 @default.
- W4283522590 cites W2104644202 @default.
- W4283522590 cites W2105769402 @default.
- W4283522590 cites W2115985679 @default.
- W4283522590 cites W2120567665 @default.
- W4283522590 cites W2130493604 @default.
- W4283522590 cites W2138286336 @default.
- W4283522590 cites W2139393829 @default.
- W4283522590 cites W2139748951 @default.
- W4283522590 cites W2142696114 @default.
- W4283522590 cites W2160936941 @default.
- W4283522590 cites W2162636859 @default.
- W4283522590 cites W2163915075 @default.