Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283523879> ?p ?o ?g. }
- W4283523879 endingPage "353" @default.
- W4283523879 startingPage "346" @default.
- W4283523879 abstract "Abstract Our recent data demonstrate a critical role of the RIG-I–like receptor family in regulating antifungal immunity against Aspergillus fumigatus in a murine model. However, the importance of this pathway in humans and the cell types that use this innate immune receptor family to detect A. fumigatus remain unresolved. In this study, using patients who underwent hematopoietic stem cell transplantation, we demonstrate that a polymorphism in human MAVS present in the donor genome was associated with the incidence of invasive pulmonary aspergillosis. Moreover, in a separate cohort of confirmed invasive pulmonary aspergillosis patients, polymorphisms in the IFIH1 gene alter the inflammatory response, including IFN-responsive chemokines. Returning to our murine model, we now demonstrate that CD11c+ Siglec F+ alveolar macrophages require Mavs expression to maintain host resistance against A. fumigatus. Our data support the role of MAVS signaling in mediating antifungal immunity in both mice and humans at least in part through the role of MAVS-dependent signaling in alveolar macrophages." @default.
- W4283523879 created "2022-06-27" @default.
- W4283523879 creator A5017151667 @default.
- W4283523879 creator A5021249910 @default.
- W4283523879 creator A5022184235 @default.
- W4283523879 creator A5049819724 @default.
- W4283523879 creator A5052656152 @default.
- W4283523879 creator A5055072083 @default.
- W4283523879 creator A5070829834 @default.
- W4283523879 creator A5074930464 @default.
- W4283523879 creator A5077587964 @default.
- W4283523879 creator A5083146403 @default.
- W4283523879 creator A5086668079 @default.
- W4283523879 date "2022-07-15" @default.
- W4283523879 modified "2023-10-03" @default.
- W4283523879 title "MAVS Expression in Alveolar Macrophages Is Essential for Host Resistance against <i>Aspergillus fumigatus</i>" @default.
- W4283523879 cites W1576281382 @default.
- W4283523879 cites W1779160407 @default.
- W4283523879 cites W1972502019 @default.
- W4283523879 cites W1973646620 @default.
- W4283523879 cites W1976613237 @default.
- W4283523879 cites W1977099733 @default.
- W4283523879 cites W1979921127 @default.
- W4283523879 cites W1981120300 @default.
- W4283523879 cites W1985496339 @default.
- W4283523879 cites W1995559954 @default.
- W4283523879 cites W2002836781 @default.
- W4283523879 cites W2013299453 @default.
- W4283523879 cites W2028189711 @default.
- W4283523879 cites W2028575270 @default.
- W4283523879 cites W2038141921 @default.
- W4283523879 cites W2039348492 @default.
- W4283523879 cites W2040775233 @default.
- W4283523879 cites W2040810194 @default.
- W4283523879 cites W2058957540 @default.
- W4283523879 cites W2067548550 @default.
- W4283523879 cites W2070359556 @default.
- W4283523879 cites W2073140442 @default.
- W4283523879 cites W2083162205 @default.
- W4283523879 cites W2087804239 @default.
- W4283523879 cites W2097192281 @default.
- W4283523879 cites W2100646399 @default.
- W4283523879 cites W2101233099 @default.
- W4283523879 cites W2108337485 @default.
- W4283523879 cites W2110812524 @default.
- W4283523879 cites W2127245371 @default.
- W4283523879 cites W2133167433 @default.
- W4283523879 cites W2145179544 @default.
- W4283523879 cites W2151939809 @default.
- W4283523879 cites W2154489345 @default.
- W4283523879 cites W2156617860 @default.
- W4283523879 cites W2157218015 @default.
- W4283523879 cites W2160242309 @default.
- W4283523879 cites W2160702475 @default.
- W4283523879 cites W2163571036 @default.
- W4283523879 cites W2166734004 @default.
- W4283523879 cites W2232997227 @default.
- W4283523879 cites W2296537795 @default.
- W4283523879 cites W2562594409 @default.
- W4283523879 cites W2576462516 @default.
- W4283523879 cites W2593309210 @default.
- W4283523879 cites W2619592111 @default.
- W4283523879 cites W2763533536 @default.
- W4283523879 cites W2768204707 @default.
- W4283523879 cites W2883014427 @default.
- W4283523879 cites W2885688680 @default.
- W4283523879 cites W2891334447 @default.
- W4283523879 cites W2927199411 @default.
- W4283523879 cites W2965760762 @default.
- W4283523879 cites W3029514565 @default.
- W4283523879 cites W3040607484 @default.
- W4283523879 cites W3048034760 @default.
- W4283523879 cites W3094281787 @default.
- W4283523879 cites W3125805949 @default.
- W4283523879 cites W4211178015 @default.
- W4283523879 cites W4229752415 @default.
- W4283523879 cites W4235908688 @default.
- W4283523879 cites W4285091948 @default.
- W4283523879 doi "https://doi.org/10.4049/jimmunol.2100759" @default.
- W4283523879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35750336" @default.
- W4283523879 hasPublicationYear "2022" @default.
- W4283523879 type Work @default.
- W4283523879 citedByCount "4" @default.
- W4283523879 countsByYear W42835238792022 @default.
- W4283523879 countsByYear W42835238792023 @default.
- W4283523879 crossrefType "journal-article" @default.
- W4283523879 hasAuthorship W4283523879A5017151667 @default.
- W4283523879 hasAuthorship W4283523879A5021249910 @default.
- W4283523879 hasAuthorship W4283523879A5022184235 @default.
- W4283523879 hasAuthorship W4283523879A5049819724 @default.
- W4283523879 hasAuthorship W4283523879A5052656152 @default.
- W4283523879 hasAuthorship W4283523879A5055072083 @default.
- W4283523879 hasAuthorship W4283523879A5070829834 @default.
- W4283523879 hasAuthorship W4283523879A5074930464 @default.
- W4283523879 hasAuthorship W4283523879A5077587964 @default.
- W4283523879 hasAuthorship W4283523879A5083146403 @default.
- W4283523879 hasAuthorship W4283523879A5086668079 @default.
- W4283523879 hasBestOaLocation W42835238791 @default.