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• W4283529211 abstract "Summary Faithful DNA replication requires the orderly firing of replication origins across the genome. At present, we lack details around how origins are selected for activation and the subsequent impact of this on replication dynamics. Here, we have investigated how chromatin organisation contributes to replication initiation and dynamics by intersecting ChIP-seq, Hi-C, Repli-seq, and OK-seq data from primary and tumour cells lines. We found replication initiation is significantly enriched at TAD boundaries, co-localizing with CTCF and cohesin in early and mid S-phase. Strong replication fork directionality (RFD) from initiation zones in TAD boundaries could occur in a bi- or uni-directional manner, which highly correlated with replication timing. While TAD boundaries were largely invariant, a minority of initiation zones were shared across cell lines, indicative of cell type specific regulation. These data are consistent with chromatin structure organizing replication initiation and dynamics, ensuring orderly completion of replication from TAD boundaries into TAD internal regions." @default.
• W4283529211 created "2022-06-27" @default.
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• W4283529211 date "2022-06-24" @default.
• W4283529211 modified "2023-09-27" @default.
• W4283529211 title "Three-dimensional chromatin organisation shapes origin activation and replication fork directionality" @default.
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• W4283529211 doi "https://doi.org/10.1101/2022.06.24.497492" @default.
• W4283529211 hasPublicationYear "2022" @default.
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