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- W4283575645 endingPage "842" @default.
- W4283575645 startingPage "825" @default.
- W4283575645 abstract "Advanced chronic liver disease is considered a reversible condition after removal of the primary etiological factor. This has led to a paradigm shift in which portal hypertension (PH) is a reversible complication of cirrhosis. The pharmacologic management of PH is centered on finding targets to modify the natural history of cirrhosis and PH.This paper offers an overview of the use of pharmacological strategies in early clinical development that modify PH. Papers included were selected from searching clinical trial sites and PubMed from the last 10 years.A paradigm shift has generated a new concept of PH in cirrhosis as a reversible complication of a potentially curable disease. Decreasing portal pressure to prevent decompensation and further complications of cirrhosis that may lead liver transplantation or death is a goal. Therapeutic strategies also aspire achieve total or partial regression of fibrosis, thus eliminating the need for treatment or screening of PH." @default.
- W4283575645 created "2022-06-28" @default.
- W4283575645 creator A5007560083 @default.
- W4283575645 creator A5012387403 @default.
- W4283575645 creator A5060976881 @default.
- W4283575645 date "2022-07-05" @default.
- W4283575645 modified "2023-09-28" @default.
- W4283575645 title "Investigational drugs in early clinical development for portal hypertension" @default.
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