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• W4283577897 abstract "Abstract Background Fungi associated with insects represent one potentially rich source for the discovery of novel metabolites. However, a comprehensive understanding of the fungal communities of Apis mellifera ligustica remains elusive. Results Here, we investigated the phylogenetic diversity and community composition of honeybee-associated fungi using combination of culture-dependent and culture-independent approaches. A total of forty-five fungi were isolated and purified from the Apis mellifera ligustica , royal jelly, and honeycomb, which belonged to four classes and eleven different genera. Furthermore, 28 bacterial 16S rRNA gene sequences were obtained by PCR from the fungal metagenome. High-throughput sequencing analyses revealed that the fungal communities were more diverse, a total of 62 fungal genera were detected in the honeybee gut by culture-independent method, whereas only 4 genera were isolated by culture-dependent method. Similarly, 247 fungal genera were detected in the honeycomb, whereas only 4 genera were isolated. In addition, we assessed the antibacterial and antioxidant activities of fungal isolates. Most fungal crude extracts obtained from the cultivation supernatant exhibited antioxidant activities. Only two fungal crude extracts displayed moderate activity against Escherichia coli and Staphylococcus aureus . Chemical analysis of Chaetomium subaffine MFFC22 led to the discovery of three known compounds, including cochliodinol ( 1 ), emodin ( 2 ), chrysophanol ( 3 ). Among them, cochliodinol ( 1 ) showed intense DPPH radical scavenging activity with the 50% inhibitory concentration (IC 50 ) of 3.06 μg/mL, which was comparable to that of the positive ascorbic acid (IC 50 = 2.25 μg/mL). Compound 2 displayed weak inhibitory activities against Micrococcus tetragenus and S. aureus . Conclusions This research provided a fundamental clue for the complex interactions among honeybees, fungi, bacterial symbionts, and the effects on the honeybee. Furthermore, the diversity of honeybee-associated fungi had great potential in finding the resource of new species and antioxidants." @default.
• W4283577897 created "2022-06-28" @default.
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• W4283577897 date "2022-06-27" @default.
• W4283577897 modified "2023-10-16" @default.
• W4283577897 title "Community composition, bacterial symbionts, antibacterial and antioxidant activities of honeybee-associated fungi" @default.
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• W4283577897 doi "https://doi.org/10.1186/s12866-022-02580-4" @default.
• W4283577897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35761187" @default.
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