FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283577925> ?p ?o ?g. }

• W4283577925 abstract "Innate lymphoid cells (ILC) are a heterogeneous and plastic population of cells of the innate immune system. Their role in cancer and specifically in hepatocellular carcinoma is unraveling. The presence of ILCs in peripheral blood of HCC patients has not been explored yet. Their role and function in response to checkpoint inhibitor therapy have also not been explored. Here, we characterized ILCs in PBMC of HCC patients at baseline and after treatment with immune checkpoint inhibitors (ICI) by flow cytometry and single-cell sequencing. Characterization of ILC subsets in PBMCs of HCC patients showed a significant increase in ILC1 and a decrease in ILC3 frequencies. Single-cell RNA-sequencing identified a subgroup of NK-like ILCs which expressed cytotoxicity markers as well as NKp80/ KLRF1 . This KLRF1 high NK-like population showed low abundance in patients with HCC and was enhanced after combined anti-CTLA-4 and anti-PD-1immunotherapy. Trajectory analysis placed this population in between ILC1 and ILC3 cells. The transcriptomic signature of KLRF1 high NK-like ILCs was associated with better progression-free survival in large HCC cohorts. This study shows a previously unknown effect of ICI on the composition and plasticity of ILCS in peripheral blood. Thus, ILCs from PBMC can be used to study changes in the innate immune system under immunotherapy." @default.
• W4283577925 created "2022-06-28" @default.
• W4283577925 creator A5008922508 @default.
• W4283577925 creator A5010198687 @default.
• W4283577925 creator A5016783165 @default.
• W4283577925 creator A5025086832 @default.
• W4283577925 creator A5025349228 @default.
• W4283577925 creator A5025405931 @default.
• W4283577925 creator A5047331780 @default.
• W4283577925 creator A5060333169 @default.
• W4283577925 creator A5067929023 @default.
• W4283577925 creator A5074169979 @default.
• W4283577925 creator A5078103351 @default.
• W4283577925 date "2022-06-27" @default.
• W4283577925 modified "2023-10-18" @default.
• W4283577925 title "Checkpoint Inhibitors Modulate Plasticity of Innate Lymphoid Cells in Peripheral Blood of Patients With Hepatocellular Carcinoma" @default.
• W4283577925 cites W2147448501 @default.
• W4283577925 cites W2158799524 @default.
• W4283577925 cites W2464909413 @default.
• W4283577925 cites W2546700240 @default.
• W4283577925 cites W2601892854 @default.
• W4283577925 cites W2606367731 @default.
• W4283577925 cites W2741163567 @default.
• W4283577925 cites W2789844817 @default.
• W4283577925 cites W2890537848 @default.
• W4283577925 cites W2902488470 @default.
• W4283577925 cites W2913248633 @default.
• W4283577925 cites W2914486061 @default.
• W4283577925 cites W2937687190 @default.
• W4283577925 cites W2989616438 @default.
• W4283577925 cites W2990602950 @default.
• W4283577925 cites W3005525322 @default.
• W4283577925 cites W3008157654 @default.
• W4283577925 cites W3008176582 @default.
• W4283577925 cites W3023424442 @default.
• W4283577925 cites W3025022288 @default.
• W4283577925 cites W3037345378 @default.
• W4283577925 cites W3134391811 @default.
• W4283577925 cites W3189406047 @default.
• W4283577925 cites W3193849547 @default.
• W4283577925 cites W4232620598 @default.
• W4283577925 doi "https://doi.org/10.3389/fimmu.2022.849958" @default.
• W4283577925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35833139" @default.
• W4283577925 hasPublicationYear "2022" @default.
• W4283577925 type Work @default.
• W4283577925 citedByCount "3" @default.
• W4283577925 countsByYear W42835779252023 @default.
• W4283577925 crossrefType "journal-article" @default.
• W4283577925 hasAuthorship W4283577925A5008922508 @default.
• W4283577925 hasAuthorship W4283577925A5010198687 @default.
• W4283577925 hasAuthorship W4283577925A5016783165 @default.
• W4283577925 hasAuthorship W4283577925A5025086832 @default.
• W4283577925 hasAuthorship W4283577925A5025349228 @default.
• W4283577925 hasAuthorship W4283577925A5025405931 @default.
• W4283577925 hasAuthorship W4283577925A5047331780 @default.
• W4283577925 hasAuthorship W4283577925A5060333169 @default.
• W4283577925 hasAuthorship W4283577925A5067929023 @default.
• W4283577925 hasAuthorship W4283577925A5074169979 @default.
• W4283577925 hasAuthorship W4283577925A5078103351 @default.
• W4283577925 hasBestOaLocation W42835779251 @default.
• W4283577925 hasConcept C104317684 @default.
• W4283577925 hasConcept C136449434 @default.
• W4283577925 hasConcept C137061746 @default.
• W4283577925 hasConcept C150194340 @default.
• W4283577925 hasConcept C162317418 @default.
• W4283577925 hasConcept C202751555 @default.
• W4283577925 hasConcept C203014093 @default.
• W4283577925 hasConcept C2777701055 @default.
• W4283577925 hasConcept C2778019345 @default.
• W4283577925 hasConcept C2780851360 @default.
• W4283577925 hasConcept C2908647359 @default.
• W4283577925 hasConcept C47742525 @default.
• W4283577925 hasConcept C502942594 @default.
• W4283577925 hasConcept C553184892 @default.
• W4283577925 hasConcept C55493867 @default.
• W4283577925 hasConcept C71924100 @default.
• W4283577925 hasConcept C86803240 @default.
• W4283577925 hasConcept C8891405 @default.
• W4283577925 hasConcept C99454951 @default.
• W4283577925 hasConceptScore W4283577925C104317684 @default.
• W4283577925 hasConceptScore W4283577925C136449434 @default.
• W4283577925 hasConceptScore W4283577925C137061746 @default.
• W4283577925 hasConceptScore W4283577925C150194340 @default.
• W4283577925 hasConceptScore W4283577925C162317418 @default.
• W4283577925 hasConceptScore W4283577925C202751555 @default.
• W4283577925 hasConceptScore W4283577925C203014093 @default.
• W4283577925 hasConceptScore W4283577925C2777701055 @default.
• W4283577925 hasConceptScore W4283577925C2778019345 @default.
• W4283577925 hasConceptScore W4283577925C2780851360 @default.
• W4283577925 hasConceptScore W4283577925C2908647359 @default.
• W4283577925 hasConceptScore W4283577925C47742525 @default.
• W4283577925 hasConceptScore W4283577925C502942594 @default.
• W4283577925 hasConceptScore W4283577925C553184892 @default.
• W4283577925 hasConceptScore W4283577925C55493867 @default.
• W4283577925 hasConceptScore W4283577925C71924100 @default.
• W4283577925 hasConceptScore W4283577925C86803240 @default.
• W4283577925 hasConceptScore W4283577925C8891405 @default.
• W4283577925 hasConceptScore W4283577925C99454951 @default.
• W4283577925 hasFunder F4320332161 @default.
• W4283577925 hasLocation W42835779251 @default.

• next