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- W4283579070 abstract "Lactate dehydrogenase (LDH) levels predict coronavirus disease 2019 (COVID-19) severity. We investigated LDH isoenzyme levels to identify the tissue responsible for serum LDH elevation in patients with COVID-19.Hospitalised COVID-19 patients with serum LDH levels exceeding the upper reference limit included. LDH isoenzymes were detected quantitatively on agarose gels. The radiological severity of lung involvement on computed tomography was scored as 0-5 for each lobe (total possible score, 0-25). Disease severity was determined using the World Health Organization (WHO) clinical progression scale.In total, 111 patients (mean age, 59.96 ± 16.14), including 43 females (38.7%), were enrolled. The serum levels of total LDH and all five LDH isoenzymes were significantly higher in the severe group. The levels of all LDH isoenzymes excluding LDH5 positively correlated with the WHO score. LDH3 levels correlated with chest computed tomography findings (r2 = 0.267, p = 0.005). On multivariate analysis, LDH3 was an independent risk factor for the deterioration of COVID-19.LDH3 appears to be an independent risk factor for deterioration in patients with COVID-19. LDH elevation in patients with COVID-19 predominantly resulted from lung, liver and muscle damage.Nivoi laktat dehidrogenaze (LDH) predviđaju ozbiljnost bolesti korona virusa 2019 (COVID-19). Istraživali smo nivoe LDH izoenzima da bismo identifikovali tkivo odgovorno za povišenje LDH u serumu kod pacijenata sa COVID-19.Uključeni su hospitalizovani pacijenti sa COVID-19 sa nivoom LDH u serumu koji prelazi gornju referentnu granicu. LDH izoenzimi su kvantitativno detektovani na agaroznim gelovima. Radiološka težina zahvata pluća na kompjuterizovanoj tomografiji ocenjena je sa 0-5 za svaki režanj (ukupan mogući rezultat, 0-25). Težina bolesti je određena korišćenjem skale kliničke progresije Svetske zdravstvene organizacije (SZO)." @default.
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- W4283579070 date "2023-01-01" @default.
- W4283579070 modified "2023-09-25" @default.
- W4283579070 title "Diagnostic performance of lactate dehydrogenase (LDH) isoenzymes levels for the severity of COVID-19" @default.
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- W4283579070 doi "https://doi.org/10.5937/jomb0-37234" @default.
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