Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283581844> ?p ?o ?g. }
- W4283581844 endingPage "1209" @default.
- W4283581844 startingPage "1197" @default.
- W4283581844 abstract "Guanine-rich regions of DNA or RNA can form structures with two or more consecutive G-quartets called G-quadruplexes (GQ). Recent studies reveal the potential for these structures to aggregate in vitro. Here, we report effects of in vivo concentrations of additives—amino acids, nucleotides, and crowding agents—on the structure and solution behavior of RNAs containing GQ-forming sequences. We found that cytosine nucleotides destabilize a model GQ structure at biological salt concentrations, while free amino acids and other nucleotides do not do so to a substantial degree. We also report that the tendency of folded GQs to form droplets or to aggregate depends on the nature of flanking sequence and the presence of additives. Notably, in the presence of biological amounts of polyamines, flanking regions on the 5′-end of the RNA drive more droplet-like phase separation, while flanking regions on the 3′-end, as well as both the 5′- and 3′-ends, induce more condensed, granular structures. Finally, we provide an example of a biological sequence in the presence of polyamines and show that crowders such as PEG and dextran can selectively cause its phase separation. These findings have implications for the participation of GQS in LLPS in vivo." @default.
- W4283581844 created "2022-06-28" @default.
- W4283581844 creator A5033421607 @default.
- W4283581844 creator A5053201698 @default.
- W4283581844 creator A5066100439 @default.
- W4283581844 creator A5073604709 @default.
- W4283581844 date "2022-06-27" @default.
- W4283581844 modified "2023-10-03" @default.
- W4283581844 title "Biological solution conditions and flanking sequence modulate LLPS of RNA G-quadruplex structures" @default.
- W4283581844 cites W1574643310 @default.
- W4283581844 cites W2004641057 @default.
- W4283581844 cites W2007186039 @default.
- W4283581844 cites W2032698727 @default.
- W4283581844 cites W2033319975 @default.
- W4283581844 cites W2039930572 @default.
- W4283581844 cites W2053208573 @default.
- W4283581844 cites W2058743915 @default.
- W4283581844 cites W2079768304 @default.
- W4283581844 cites W2096163866 @default.
- W4283581844 cites W2108763751 @default.
- W4283581844 cites W2116609429 @default.
- W4283581844 cites W2131187223 @default.
- W4283581844 cites W2136524572 @default.
- W4283581844 cites W2141157874 @default.
- W4283581844 cites W2150201930 @default.
- W4283581844 cites W2155773930 @default.
- W4283581844 cites W2166976426 @default.
- W4283581844 cites W2314437490 @default.
- W4283581844 cites W2338236108 @default.
- W4283581844 cites W2346094579 @default.
- W4283581844 cites W2477718940 @default.
- W4283581844 cites W2510312826 @default.
- W4283581844 cites W2518087534 @default.
- W4283581844 cites W2518362417 @default.
- W4283581844 cites W2522261353 @default.
- W4283581844 cites W2780438117 @default.
- W4283581844 cites W2807593658 @default.
- W4283581844 cites W2943016774 @default.
- W4283581844 cites W2943624515 @default.
- W4283581844 cites W2944999050 @default.
- W4283581844 cites W2972781930 @default.
- W4283581844 cites W2987435148 @default.
- W4283581844 cites W3000047107 @default.
- W4283581844 cites W3000889356 @default.
- W4283581844 cites W3014677172 @default.
- W4283581844 cites W3087642411 @default.
- W4283581844 cites W3174811455 @default.
- W4283581844 cites W3183669650 @default.
- W4283581844 cites W3195088461 @default.
- W4283581844 doi "https://doi.org/10.1261/rna.079196.122" @default.
- W4283581844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35760522" @default.
- W4283581844 hasPublicationYear "2022" @default.
- W4283581844 type Work @default.
- W4283581844 citedByCount "4" @default.
- W4283581844 countsByYear W42835818442022 @default.
- W4283581844 countsByYear W42835818442023 @default.
- W4283581844 crossrefType "journal-article" @default.
- W4283581844 hasAuthorship W4283581844A5033421607 @default.
- W4283581844 hasAuthorship W4283581844A5053201698 @default.
- W4283581844 hasAuthorship W4283581844A5066100439 @default.
- W4283581844 hasAuthorship W4283581844A5073604709 @default.
- W4283581844 hasBestOaLocation W42835818442 @default.
- W4283581844 hasConcept C104317684 @default.
- W4283581844 hasConcept C12554922 @default.
- W4283581844 hasConcept C24107716 @default.
- W4283581844 hasConcept C2778112365 @default.
- W4283581844 hasConcept C2778301229 @default.
- W4283581844 hasConcept C512185932 @default.
- W4283581844 hasConcept C552990157 @default.
- W4283581844 hasConcept C55493867 @default.
- W4283581844 hasConcept C67705224 @default.
- W4283581844 hasConcept C83762044 @default.
- W4283581844 hasConcept C86803240 @default.
- W4283581844 hasConceptScore W4283581844C104317684 @default.
- W4283581844 hasConceptScore W4283581844C12554922 @default.
- W4283581844 hasConceptScore W4283581844C24107716 @default.
- W4283581844 hasConceptScore W4283581844C2778112365 @default.
- W4283581844 hasConceptScore W4283581844C2778301229 @default.
- W4283581844 hasConceptScore W4283581844C512185932 @default.
- W4283581844 hasConceptScore W4283581844C552990157 @default.
- W4283581844 hasConceptScore W4283581844C55493867 @default.
- W4283581844 hasConceptScore W4283581844C67705224 @default.
- W4283581844 hasConceptScore W4283581844C83762044 @default.
- W4283581844 hasConceptScore W4283581844C86803240 @default.
- W4283581844 hasFunder F4320332161 @default.
- W4283581844 hasIssue "9" @default.
- W4283581844 hasLocation W42835818441 @default.
- W4283581844 hasLocation W42835818442 @default.
- W4283581844 hasLocation W42835818443 @default.
- W4283581844 hasOpenAccess W4283581844 @default.
- W4283581844 hasPrimaryLocation W42835818441 @default.
- W4283581844 hasRelatedWork W1985254234 @default.
- W4283581844 hasRelatedWork W1985445036 @default.
- W4283581844 hasRelatedWork W2032503181 @default.
- W4283581844 hasRelatedWork W2059177774 @default.
- W4283581844 hasRelatedWork W2067218560 @default.
- W4283581844 hasRelatedWork W2499154798 @default.
- W4283581844 hasRelatedWork W2515311730 @default.