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- W4283583947 abstract "GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development. In recent years, GPX4 has been associated with a cell death modality dubbed ferroptosis. The framing of this molecular pathway of cell death was essential for understanding the conditions that determine GPX4 dependency and ultimately to the process of lipid peroxidation. Since its discovery, ferroptosis has been gaining momentum as a promising target for yet-incurable diseases, including cancer and neurodegeneration. Given the current interest, in the present review, we provide newcomers in the field with an overview of the biology of GPX4 and cover some of its most recent discoveries." @default.
- W4283583947 created "2022-06-28" @default.
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- W4283583947 creator A5075844908 @default.
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- W4283583947 date "2022-06-27" @default.
- W4283583947 modified "2023-10-18" @default.
- W4283583947 title "GPX4: old lessons, new features" @default.
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- W4283583947 doi "https://doi.org/10.1042/bst20220682" @default.
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