FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283587712> ?p ?o ?g. }

• W4283587712 abstract "Parathyroid hormone-related peptide (PTHrP) overexpression and poor patient outcome have been reported for many human tumors, but no studies are available in laryngeal cancer. Therefore, we studied the expression of PTHrP and its receptor, parathyroid hormone-related peptide receptor type 1 (PTH1R), in primary locally advanced laryngeal squamous cell carcinomas (LALSCC) also in relation to the clinical outcome of patients.We conducted a retrospective exploratory study, using immunohistochemistry, on PTHrP, PTH1R and HER1 expressions in LALSCC of 66 patients treated with bio-radiotherapy with cetuximab.The expressions of PTHrP and PTH1R in LALSCC were associated with the degree of tumor differentiation (p = 0.01 and 0.04, respectively). Poorly differentiated tumors, with worse prognosis, expressed PTHrP at nuclear level and were PTH1R negative. PTHrP and PTH1R were expressed at cytoplasmic level in normal larynx epithelium and more differentiated laryngeal cancer cells, suggesting an autocrine/paracrine role of PTHrP in squamous cell differentiation of well differentiated tumors with good prognosis. Eighty-one percent HER1 positive tumors expressed PTHrP (p < 0.0001), mainly at nuclear level, consistent with the known up-regulation of PTHrP gene by HER1 signaling. In multivariable analyses, patients with PTHrP positive tumors had a higher relative risk of relapse (HR = 5.49; CI 95% = 1.62-22.24; p = 0.006) and survival (HR = 8.21; CI 95% = 1.19-105.00; p = 0.031) while those with PTH1R positive tumors showed a lower relative risk of relapse (HR = 0.18; CI 95% = 0.04-0.62; p = 0.002) and survival (HR = 0.18; CI 95% = 0.04-0.91; p = 0.029).In LALSCC nuclear PTHrP and absence of PTH1R expressions could be useful in predicting response and/or resistance to cetuximab in combined therapies, contributing to an aggressive behavior of tumor cells downstream to HER1." @default.
• W4283587712 created "2022-06-28" @default.
• W4283587712 creator A5020706240 @default.
• W4283587712 creator A5022481436 @default.
• W4283587712 creator A5026031154 @default.
• W4283587712 creator A5034384991 @default.
• W4283587712 creator A5037735176 @default.
• W4283587712 creator A5049663933 @default.
• W4283587712 creator A5064117661 @default.
• W4283587712 creator A5066850232 @default.
• W4283587712 creator A5082343940 @default.
• W4283587712 creator A5090151706 @default.
• W4283587712 date "2022-06-27" @default.
• W4283587712 modified "2023-10-16" @default.
• W4283587712 title "Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival" @default.
• W4283587712 cites W1897048475 @default.
• W4283587712 cites W1965723545 @default.
• W4283587712 cites W1968231448 @default.
• W4283587712 cites W1977978354 @default.
• W4283587712 cites W1983950276 @default.
• W4283587712 cites W1995296863 @default.
• W4283587712 cites W1996338284 @default.
• W4283587712 cites W2007410879 @default.
• W4283587712 cites W2013325209 @default.
• W4283587712 cites W2013673508 @default.
• W4283587712 cites W2018171662 @default.
• W4283587712 cites W2020600496 @default.
• W4283587712 cites W2020814497 @default.
• W4283587712 cites W2033051771 @default.
• W4283587712 cites W2033384572 @default.
• W4283587712 cites W2037602535 @default.
• W4283587712 cites W2048440069 @default.
• W4283587712 cites W2050072859 @default.
• W4283587712 cites W2063249351 @default.
• W4283587712 cites W2066289570 @default.
• W4283587712 cites W2066440600 @default.
• W4283587712 cites W2067224845 @default.
• W4283587712 cites W2067624522 @default.
• W4283587712 cites W2068368984 @default.
• W4283587712 cites W2082151433 @default.
• W4283587712 cites W2086185736 @default.
• W4283587712 cites W2088092421 @default.
• W4283587712 cites W2088673593 @default.
• W4283587712 cites W2089257078 @default.
• W4283587712 cites W2089663915 @default.
• W4283587712 cites W2100961085 @default.
• W4283587712 cites W2102792309 @default.
• W4283587712 cites W2115709314 @default.
• W4283587712 cites W2119092744 @default.
• W4283587712 cites W2119991653 @default.
• W4283587712 cites W2124504541 @default.
• W4283587712 cites W2126267208 @default.
• W4283587712 cites W2142217243 @default.
• W4283587712 cites W2149445862 @default.
• W4283587712 cites W2151730005 @default.
• W4283587712 cites W2155384808 @default.
• W4283587712 cites W2156382128 @default.
• W4283587712 cites W2158648950 @default.
• W4283587712 cites W2164675754 @default.
• W4283587712 cites W2164934175 @default.
• W4283587712 cites W2165682857 @default.
• W4283587712 cites W2166249610 @default.
• W4283587712 cites W2235523093 @default.
• W4283587712 cites W24859530 @default.
• W4283587712 cites W2562414697 @default.
• W4283587712 cites W2563652063 @default.
• W4283587712 cites W2580333090 @default.
• W4283587712 cites W2599366928 @default.
• W4283587712 cites W2807637167 @default.
• W4283587712 cites W2903267449 @default.
• W4283587712 cites W2944098935 @default.
• W4283587712 cites W2961422450 @default.
• W4283587712 cites W3092413872 @default.
• W4283587712 cites W3139499922 @default.
• W4283587712 cites W4241693338 @default.
• W4283587712 doi "https://doi.org/10.1186/s12885-022-09748-1" @default.
• W4283587712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35761298" @default.
• W4283587712 hasPublicationYear "2022" @default.
• W4283587712 type Work @default.
• W4283587712 citedByCount "2" @default.
• W4283587712 countsByYear W42835877122023 @default.
• W4283587712 crossrefType "journal-article" @default.
• W4283587712 hasAuthorship W4283587712A5020706240 @default.
• W4283587712 hasAuthorship W4283587712A5022481436 @default.
• W4283587712 hasAuthorship W4283587712A5026031154 @default.
• W4283587712 hasAuthorship W4283587712A5034384991 @default.
• W4283587712 hasAuthorship W4283587712A5037735176 @default.
• W4283587712 hasAuthorship W4283587712A5049663933 @default.
• W4283587712 hasAuthorship W4283587712A5064117661 @default.
• W4283587712 hasAuthorship W4283587712A5066850232 @default.
• W4283587712 hasAuthorship W4283587712A5082343940 @default.
• W4283587712 hasAuthorship W4283587712A5090151706 @default.
• W4283587712 hasBestOaLocation W42835877121 @default.
• W4283587712 hasConcept C121608353 @default.
• W4283587712 hasConcept C126322002 @default.
• W4283587712 hasConcept C128240485 @default.
• W4283587712 hasConcept C134018914 @default.
• W4283587712 hasConcept C143998085 @default.
• W4283587712 hasConcept C170493617 @default.
• W4283587712 hasConcept C204232928 @default.

• next