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- W4283589386 abstract "Among kids and juveniles, osteosarcoma (OS) is a common bone malignancy. Circular RNAs (circs, circRNAs) play important roles in multiple malignancies including OS, yet circ_0078767's biological functions in OS are far from well elucidated. This study is targeted at understanding circ_0078767's biological functions in OS and its molecular mechanisms. This study confirmed that circ_0078767 expression was reduced in OS cell lines and tissues. Circ_0078767 overexpression remarkably inhibited OS cell growth, migration, invasion, epithelial-mesenchymal transition (EMT), and promoted apoptosis, whereas circ_0078767 knockdown resulted in the opposite effects. MicroRNA-889 (miR-889) was targeted and regulated by circ_0078767, and miR-889 could negatively modulate Kruppel-like factor 9 (KLF9) expression. Besides, circ_0078767 positively regulated KLF9 expression in OS cells via repressing miR-889. In conclusion, circ_0078767 enhances KLF9 expression by targeting miR-889 to inhibit OS progression." @default.
- W4283589386 created "2022-06-28" @default.
- W4283589386 creator A5046681030 @default.
- W4283589386 creator A5063626071 @default.
- W4283589386 creator A5091201855 @default.
- W4283589386 date "2022-06-01" @default.
- W4283589386 modified "2023-09-27" @default.
- W4283589386 title "Circular RNA_0078767 upregulates Kruppel-like factor 9 expression by targeting microRNA-889, thereby inhibiting the progression of osteosarcoma" @default.
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- W4283589386 doi "https://doi.org/10.1080/21655979.2022.2084257" @default.
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