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• W4283592718 abstract "Gliomas, a type of primary brain tumor, have emerged as a threat to global mortality due to their high heterogeneity and mortality. A low-grade glioma (LGG), although less aggressive compared with glioblastoma, still exhibits high recurrence and malignant progression. Ubiquitination is one of the most important posttranslational modifications that contribute to carcinogenesis and cancer recurrence. E3-related genes (E3RGs) play essential roles in the process of ubiquitination. Yet, the biological function and clinical significance of E3RGs in LGGs need further exploration. In this study, differentially expressed genes (DEGs) were screened by three differential expression analyses of LGG samples from The Cancer Genome Atlas (TCGA) database. DEGs with prognostic significance were selected by the univariate Cox regression analysis and log-rank statistical test. The LASSO-COX method was performed to identify an E3-related prognostic signature consisting of seven genes AURKA, PCGF2, MAP3K1, TRIM34, PRKN, TLE3, and TRIM17. The Chinese Glioma Genome Atlas (CGGA) dataset was used as the validation cohort. Kaplan-Meier survival analysis showed that LGG patients in the low-risk group had significantly higher overall survival time than those in the high-risk group in both TCGA and CGGA cohorts. Furthermore, multivariate Cox regression analysis revealed that the E3RG signature could be used as an independent prognostic factor. A nomogram based on the E3RG signature was then established and provided the prediction of the 1-, 3-, and 5-year survival probability of patients with LGGs. Moreover, DEGs were analyzed based on the risk signature, on which function analyses were performed. GO and KEGG analyses uncovered gene enrichment in extracellular matrix-related functions and immune-related biological processes in the high-risk group. GSEA revealed high enrichment in pathways that promote tumorigenesis and progression in the high-risk group. Furthermore, ESTIMATE algorithm analysis showed a significant difference in immune and stroma activity between high- and low-risk groups. Positive correlations between the risk signature and the tumor microenvironment immune cell infiltration and immune checkpoint molecules were also observed, implying that patients with the high-risk score may have better responses to immunotherapy. Overall, our findings might provide potential diagnostic and prognostic markers for LGG patients and offer meaningful insight for individualized treatment." @default.
• W4283592718 created "2022-06-28" @default.
• W4283592718 creator A5012582924 @default.
• W4283592718 creator A5028083286 @default.
• W4283592718 creator A5055579318 @default.
• W4283592718 creator A5063292886 @default.
• W4283592718 creator A5066562420 @default.
• W4283592718 date "2022-06-27" @default.
• W4283592718 modified "2023-10-01" @default.
• W4283592718 title "Comprehensive Characterization of a Novel E3-Related Gene Signature With Implications in Prognosis and Immunotherapy of Low-Grade Gliomas" @default.
• W4283592718 cites W1195715571 @default.
• W4283592718 cites W1812256879 @default.
• W4283592718 cites W1906566368 @default.
• W4283592718 cites W1958512987 @default.
• W4283592718 cites W1964081206 @default.
• W4283592718 cites W1966107523 @default.
• W4283592718 cites W1976041483 @default.
• W4283592718 cites W1990633920 @default.
• W4283592718 cites W1991841644 @default.
• W4283592718 cites W1995117011 @default.
• W4283592718 cites W2005066107 @default.
• W4283592718 cites W2007653671 @default.
• W4283592718 cites W2010573862 @default.
• W4283592718 cites W2030199647 @default.
• W4283592718 cites W2035618305 @default.
• W4283592718 cites W2035799305 @default.
• W4283592718 cites W2039207601 @default.
• W4283592718 cites W2044182846 @default.
• W4283592718 cites W2053129716 @default.
• W4283592718 cites W2053393698 @default.
• W4283592718 cites W2066659565 @default.
• W4283592718 cites W2086239621 @default.
• W4283592718 cites W2097360283 @default.
• W4283592718 cites W2099180770 @default.
• W4283592718 cites W2105178859 @default.
• W4283592718 cites W2107940314 @default.
• W4283592718 cites W2109816625 @default.
• W4283592718 cites W2111365053 @default.
• W4283592718 cites W2113942802 @default.
• W4283592718 cites W2114104545 @default.
• W4283592718 cites W2114586150 @default.
• W4283592718 cites W2118278569 @default.
• W4283592718 cites W2123105952 @default.
• W4283592718 cites W2130430382 @default.
• W4283592718 cites W2136662615 @default.
• W4283592718 cites W2136676465 @default.
• W4283592718 cites W2137530154 @default.
• W4283592718 cites W2139364069 @default.
• W4283592718 cites W2140721485 @default.
• W4283592718 cites W2146512944 @default.
• W4283592718 cites W2148000660 @default.
• W4283592718 cites W2156448679 @default.
• W4283592718 cites W2159675211 @default.
• W4283592718 cites W2159707944 @default.
• W4283592718 cites W2179438025 @default.
• W4283592718 cites W2190672185 @default.
• W4283592718 cites W2192314619 @default.
• W4283592718 cites W2304335366 @default.
• W4283592718 cites W2310326452 @default.
• W4283592718 cites W2499269053 @default.
• W4283592718 cites W2553689505 @default.
• W4283592718 cites W2581489880 @default.
• W4283592718 cites W2589128400 @default.
• W4283592718 cites W2749025438 @default.
• W4283592718 cites W2755866416 @default.
• W4283592718 cites W2763548994 @default.
• W4283592718 cites W2774878811 @default.
• W4283592718 cites W2778033786 @default.
• W4283592718 cites W2782005123 @default.
• W4283592718 cites W2786987313 @default.
• W4283592718 cites W2883168826 @default.
• W4283592718 cites W2886441795 @default.
• W4283592718 cites W2900007365 @default.
• W4283592718 cites W2900569176 @default.
• W4283592718 cites W2901528543 @default.
• W4283592718 cites W2914719317 @default.
• W4283592718 cites W2923057410 @default.
• W4283592718 cites W2949273159 @default.
• W4283592718 cites W2959497269 @default.
• W4283592718 cites W2963298763 @default.
• W4283592718 cites W2970868197 @default.
• W4283592718 cites W2978170629 @default.
• W4283592718 cites W2980668540 @default.
• W4283592718 cites W3007343537 @default.
• W4283592718 cites W3009097360 @default.
• W4283592718 cites W3093080646 @default.
• W4283592718 cites W3093138698 @default.
• W4283592718 cites W3135861642 @default.
• W4283592718 cites W3136669063 @default.
• W4283592718 cites W3160556876 @default.
• W4283592718 cites W3170174501 @default.
• W4283592718 cites W3196458428 @default.
• W4283592718 cites W3199845477 @default.
• W4283592718 cites W3207944698 @default.
• W4283592718 cites W3209073993 @default.
• W4283592718 cites W4200437730 @default.
• W4283592718 cites W4200537911 @default.
• W4283592718 cites W4205155444 @default.
• W4283592718 cites W4206785358 @default.
• W4283592718 cites W4210644912 @default.

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