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- W4283593626 abstract "ATP-binding cassette (ABC) transporters are membrane-spanning proteins involved in cholesterol homeostasis, transport of various molecules in and out of cells and organelles, oxidative stress, immune recognition, and drug efflux. They are long implicated in the development of multidrug resistance in cancer chemotherapy. Existing clinical and molecular evidence has also linked ABC transporters with cancer pathogenesis, prognostics, and therapy. In this review, we aim to provide a comprehensive update on all ABC transporters and their roles in drug resistance in breast cancer (BC). For solid tumours such as BC, various ABC transporters are highly expressed in less differentiated subtypes and metastases. ABCA1, ABCB1 and ABCG2 are key players in BC chemoresistance. Restraining these transporters has evolved as a possible mechanism to reverse this phenomenon. Further, ABCB1 and ABCC1 are important in BC prognosis. Newer therapeutic approaches have been developed to target all these molecules to dysregulate their effect, reduce cell viability, induce apoptosis, and increase drug sensitivity. In the future, targeted therapy for specific genetic variations and upstream or downstream molecules can help improve patient prognosis." @default.
- W4283593626 created "2022-06-28" @default.
- W4283593626 creator A5008921780 @default.
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- W4283593626 creator A5077842345 @default.
- W4283593626 date "2022-06-26" @default.
- W4283593626 modified "2023-10-17" @default.
- W4283593626 title "ABC transporters in breast cancer: their roles in multidrug resistance and beyond" @default.
- W4283593626 cites W1071048366 @default.
- W4283593626 cites W1087049433 @default.
- W4283593626 cites W1553345136 @default.
- W4283593626 cites W1710176300 @default.
- W4283593626 cites W1855644362 @default.
- W4283593626 cites W1964613080 @default.
- W4283593626 cites W1966635974 @default.
- W4283593626 cites W1968600119 @default.
- W4283593626 cites W1975000966 @default.
- W4283593626 cites W1980226646 @default.
- W4283593626 cites W1987031003 @default.
- W4283593626 cites W1990512358 @default.
- W4283593626 cites W1990575393 @default.
- W4283593626 cites W1992661182 @default.
- W4283593626 cites W1992982427 @default.
- W4283593626 cites W1995561504 @default.
- W4283593626 cites W1996222830 @default.
- W4283593626 cites W1996654090 @default.
- W4283593626 cites W1996689388 @default.
- W4283593626 cites W1997878542 @default.
- W4283593626 cites W2000610587 @default.
- W4283593626 cites W2002118617 @default.
- W4283593626 cites W2008121262 @default.
- W4283593626 cites W2011320714 @default.
- W4283593626 cites W2013231650 @default.
- W4283593626 cites W2014593961 @default.
- W4283593626 cites W2016972604 @default.
- W4283593626 cites W2020224261 @default.
- W4283593626 cites W2022242801 @default.
- W4283593626 cites W2028533496 @default.
- W4283593626 cites W2029717892 @default.
- W4283593626 cites W2031772724 @default.
- W4283593626 cites W2048047193 @default.
- W4283593626 cites W2048726850 @default.
- W4283593626 cites W2051413562 @default.
- W4283593626 cites W2055904567 @default.
- W4283593626 cites W2056041359 @default.
- W4283593626 cites W2062819530 @default.
- W4283593626 cites W2063091067 @default.
- W4283593626 cites W2064840895 @default.
- W4283593626 cites W2065863894 @default.
- W4283593626 cites W2066002694 @default.
- W4283593626 cites W2073198041 @default.
- W4283593626 cites W2076174476 @default.
- W4283593626 cites W2076295610 @default.
- W4283593626 cites W2079861630 @default.
- W4283593626 cites W2081406136 @default.
- W4283593626 cites W2083333534 @default.
- W4283593626 cites W2085979770 @default.
- W4283593626 cites W2086299158 @default.
- W4283593626 cites W2094303590 @default.
- W4283593626 cites W2098885754 @default.
- W4283593626 cites W2107919309 @default.
- W4283593626 cites W2108321597 @default.
- W4283593626 cites W2110224135 @default.
- W4283593626 cites W2115209337 @default.
- W4283593626 cites W2116513340 @default.
- W4283593626 cites W2116632332 @default.
- W4283593626 cites W2126972354 @default.
- W4283593626 cites W2127247883 @default.
- W4283593626 cites W2127815633 @default.
- W4283593626 cites W2130363647 @default.
- W4283593626 cites W2131730345 @default.
- W4283593626 cites W2131851850 @default.
- W4283593626 cites W2134872783 @default.
- W4283593626 cites W2140744545 @default.
- W4283593626 cites W2142024216 @default.
- W4283593626 cites W2144572305 @default.
- W4283593626 cites W2154040159 @default.
- W4283593626 cites W2157393167 @default.
- W4283593626 cites W2161041263 @default.
- W4283593626 cites W2161926177 @default.
- W4283593626 cites W2161954129 @default.
- W4283593626 cites W2171188320 @default.
- W4283593626 cites W2171661161 @default.
- W4283593626 cites W2174206937 @default.
- W4283593626 cites W2178675427 @default.
- W4283593626 cites W2198090369 @default.
- W4283593626 cites W2199593395 @default.
- W4283593626 cites W2242917430 @default.
- W4283593626 cites W2255059492 @default.
- W4283593626 cites W2261881668 @default.
- W4283593626 cites W2276294749 @default.
- W4283593626 cites W2319754980 @default.
- W4283593626 cites W2325140777 @default.