Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283640174> ?p ?o ?g. }
- W4283640174 endingPage "1645" @default.
- W4283640174 startingPage "1639" @default.
- W4283640174 abstract "Serotonin is a well-known neurotransmitter that is synthesized from the amino acid, tryptophan. To date, more than 14 different serotonin receptors have been discovered; they exist universally in our body and enable diverse biological functions in different organs. Central serotonin regulates mood and behavior, and impacts the systemic energy balance by decreasing appetite. A number of drugs that modulate central serotonin function (e.g., fenfluramine, sibutramine and lorcaserin) were approved and used as anti-obesity drugs, but then later withdrawn due to adverse cardiovascular and carcinogenic effects. Over the past decade, the role of peripheral serotonin in regulating systemic energy metabolism has been extensively explored using tissue-specific knockout animal models. By inhibiting the action of serotonin in liver and adipose tissues, hepatic steatosis was improved and lipid accumulation was mitigated, respectively. Recent findings show that modulation of the serotonergic system is a promising therapeutic target for metabolic diseases. This review summarizes the role of serotonin in regulating energy metabolism in different organs, and discusses the potential of serotonin modulation for treating metabolic diseases." @default.
- W4283640174 created "2022-06-29" @default.
- W4283640174 creator A5004697914 @default.
- W4283640174 creator A5030222404 @default.
- W4283640174 creator A5046123622 @default.
- W4283640174 date "2022-07-23" @default.
- W4283640174 modified "2023-10-02" @default.
- W4283640174 title "Serotonin in the regulation of systemic energy metabolism" @default.
- W4283640174 cites W1969626298 @default.
- W4283640174 cites W1976114760 @default.
- W4283640174 cites W1982489750 @default.
- W4283640174 cites W1996234987 @default.
- W4283640174 cites W1998807018 @default.
- W4283640174 cites W2004728383 @default.
- W4283640174 cites W2007486557 @default.
- W4283640174 cites W2033669466 @default.
- W4283640174 cites W2038500073 @default.
- W4283640174 cites W2045164759 @default.
- W4283640174 cites W2050608961 @default.
- W4283640174 cites W2051567027 @default.
- W4283640174 cites W2065057134 @default.
- W4283640174 cites W2067357799 @default.
- W4283640174 cites W2085444790 @default.
- W4283640174 cites W2108400677 @default.
- W4283640174 cites W2118940609 @default.
- W4283640174 cites W2135190897 @default.
- W4283640174 cites W2138071306 @default.
- W4283640174 cites W2140173180 @default.
- W4283640174 cites W2161395021 @default.
- W4283640174 cites W2162021136 @default.
- W4283640174 cites W2170915933 @default.
- W4283640174 cites W2230681148 @default.
- W4283640174 cites W2329777417 @default.
- W4283640174 cites W2563394258 @default.
- W4283640174 cites W2593129012 @default.
- W4283640174 cites W2745109209 @default.
- W4283640174 cites W2766012191 @default.
- W4283640174 cites W2888562652 @default.
- W4283640174 cites W2901753855 @default.
- W4283640174 cites W2922441457 @default.
- W4283640174 cites W2957480920 @default.
- W4283640174 cites W2980163224 @default.
- W4283640174 cites W2993252030 @default.
- W4283640174 cites W3005426237 @default.
- W4283640174 cites W3015933843 @default.
- W4283640174 cites W3021541906 @default.
- W4283640174 cites W3022163167 @default.
- W4283640174 cites W3024794342 @default.
- W4283640174 cites W3039263135 @default.
- W4283640174 cites W3084409364 @default.
- W4283640174 cites W3093480251 @default.
- W4283640174 cites W3119082775 @default.
- W4283640174 cites W3137816310 @default.
- W4283640174 cites W3154925940 @default.
- W4283640174 cites W3190406477 @default.
- W4283640174 cites W3199420309 @default.
- W4283640174 cites W4200245448 @default.
- W4283640174 cites W4226017496 @default.
- W4283640174 cites W980554240 @default.
- W4283640174 doi "https://doi.org/10.1111/jdi.13879" @default.
- W4283640174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35762288" @default.
- W4283640174 hasPublicationYear "2022" @default.
- W4283640174 type Work @default.
- W4283640174 citedByCount "7" @default.
- W4283640174 countsByYear W42836401742022 @default.
- W4283640174 countsByYear W42836401742023 @default.
- W4283640174 crossrefType "journal-article" @default.
- W4283640174 hasAuthorship W4283640174A5004697914 @default.
- W4283640174 hasAuthorship W4283640174A5030222404 @default.
- W4283640174 hasAuthorship W4283640174A5046123622 @default.
- W4283640174 hasBestOaLocation W42836401743 @default.
- W4283640174 hasConcept C126322002 @default.
- W4283640174 hasConcept C134018914 @default.
- W4283640174 hasConcept C170493617 @default.
- W4283640174 hasConcept C2775864247 @default.
- W4283640174 hasConcept C2776219046 @default.
- W4283640174 hasConcept C2779638493 @default.
- W4283640174 hasConcept C2780179036 @default.
- W4283640174 hasConcept C2781083316 @default.
- W4283640174 hasConcept C37000724 @default.
- W4283640174 hasConcept C53910766 @default.
- W4283640174 hasConcept C71924100 @default.
- W4283640174 hasConcept C98274493 @default.
- W4283640174 hasConceptScore W4283640174C126322002 @default.
- W4283640174 hasConceptScore W4283640174C134018914 @default.
- W4283640174 hasConceptScore W4283640174C170493617 @default.
- W4283640174 hasConceptScore W4283640174C2775864247 @default.
- W4283640174 hasConceptScore W4283640174C2776219046 @default.
- W4283640174 hasConceptScore W4283640174C2779638493 @default.
- W4283640174 hasConceptScore W4283640174C2780179036 @default.
- W4283640174 hasConceptScore W4283640174C2781083316 @default.
- W4283640174 hasConceptScore W4283640174C37000724 @default.
- W4283640174 hasConceptScore W4283640174C53910766 @default.
- W4283640174 hasConceptScore W4283640174C71924100 @default.
- W4283640174 hasConceptScore W4283640174C98274493 @default.
- W4283640174 hasIssue "10" @default.
- W4283640174 hasLocation W42836401741 @default.
- W4283640174 hasLocation W42836401742 @default.