Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283642177> ?p ?o ?g. }
- W4283642177 abstract "The endoplasmic reticulum (ER)-mitochondria contact site (ERMCS) is crucial for exchanging biological molecules such as phospholipids and Ca2+ ions between these organelles. Mitoguardin-2 (MIGA2), a mitochondrial outer membrane protein, forms the ERMCS in higher eukaryotic cells. Here, we report the crystal structures of the MIGA2 Lipid Droplet (LD) targeting domain and the ER membrane protein VAPB bound to the phosphorylated FFAT motif of MIGA2. These structures reveal that the MIGA2 LD targeting domain has a large internal hydrophobic pocket that accommodates phospholipids and that two phosphorylations of the FFAT motif are required for tight interaction of MIGA2 with VAPB, which enhances the rate of lipid transport. Further biochemical studies show that MIGA2 transports phospholipids between membranes with a strong preference for binding and trafficking phosphatidylserine (PS). These results provide a structural and molecular basis for understanding how MIGA2 mediates the formation of ERMCS and facilitates lipid trafficking at the ERMCS." @default.
- W4283642177 created "2022-06-29" @default.
- W4283642177 creator A5010846406 @default.
- W4283642177 creator A5021006698 @default.
- W4283642177 creator A5052423346 @default.
- W4283642177 creator A5084371987 @default.
- W4283642177 date "2022-06-28" @default.
- W4283642177 modified "2023-10-17" @default.
- W4283642177 title "Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites" @default.
- W4283642177 cites W1539796472 @default.
- W4283642177 cites W1963354829 @default.
- W4283642177 cites W1969622294 @default.
- W4283642177 cites W1977222014 @default.
- W4283642177 cites W1982891627 @default.
- W4283642177 cites W1986318660 @default.
- W4283642177 cites W1990016625 @default.
- W4283642177 cites W2013660990 @default.
- W4283642177 cites W2018171488 @default.
- W4283642177 cites W2029582401 @default.
- W4283642177 cites W2032362466 @default.
- W4283642177 cites W2033455479 @default.
- W4283642177 cites W2050722665 @default.
- W4283642177 cites W2051859281 @default.
- W4283642177 cites W2066088939 @default.
- W4283642177 cites W2070847413 @default.
- W4283642177 cites W2089860059 @default.
- W4283642177 cites W2096579721 @default.
- W4283642177 cites W2099582088 @default.
- W4283642177 cites W2105951745 @default.
- W4283642177 cites W2107099939 @default.
- W4283642177 cites W2117692658 @default.
- W4283642177 cites W2121330845 @default.
- W4283642177 cites W2124026197 @default.
- W4283642177 cites W2128484647 @default.
- W4283642177 cites W2135466257 @default.
- W4283642177 cites W2139942857 @default.
- W4283642177 cites W2146403365 @default.
- W4283642177 cites W2159756099 @default.
- W4283642177 cites W2163341755 @default.
- W4283642177 cites W2170376656 @default.
- W4283642177 cites W2180229411 @default.
- W4283642177 cites W2182369134 @default.
- W4283642177 cites W2210027331 @default.
- W4283642177 cites W2233665003 @default.
- W4283642177 cites W2288568691 @default.
- W4283642177 cites W2338392719 @default.
- W4283642177 cites W2549836295 @default.
- W4283642177 cites W2580573179 @default.
- W4283642177 cites W2618913695 @default.
- W4283642177 cites W2766127467 @default.
- W4283642177 cites W2766608142 @default.
- W4283642177 cites W2777157902 @default.
- W4283642177 cites W2787879899 @default.
- W4283642177 cites W2792387716 @default.
- W4283642177 cites W2884933978 @default.
- W4283642177 cites W2917971401 @default.
- W4283642177 cites W2968046147 @default.
- W4283642177 cites W2980601854 @default.
- W4283642177 cites W3003287532 @default.
- W4283642177 cites W3004024735 @default.
- W4283642177 cites W3013844368 @default.
- W4283642177 cites W3041430230 @default.
- W4283642177 cites W3096235246 @default.
- W4283642177 cites W3102267139 @default.
- W4283642177 cites W3133682631 @default.
- W4283642177 cites W3157963341 @default.
- W4283642177 cites W4255677297 @default.
- W4283642177 doi "https://doi.org/10.1038/s41467-022-31462-6" @default.
- W4283642177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35764626" @default.
- W4283642177 hasPublicationYear "2022" @default.
- W4283642177 type Work @default.
- W4283642177 citedByCount "15" @default.
- W4283642177 countsByYear W42836421772022 @default.
- W4283642177 countsByYear W42836421772023 @default.
- W4283642177 crossrefType "journal-article" @default.
- W4283642177 hasAuthorship W4283642177A5010846406 @default.
- W4283642177 hasAuthorship W4283642177A5021006698 @default.
- W4283642177 hasAuthorship W4283642177A5052423346 @default.
- W4283642177 hasAuthorship W4283642177A5084371987 @default.
- W4283642177 hasBestOaLocation W42836421771 @default.
- W4283642177 hasConcept C143840085 @default.
- W4283642177 hasConcept C144647389 @default.
- W4283642177 hasConcept C158617107 @default.
- W4283642177 hasConcept C161200384 @default.
- W4283642177 hasConcept C168240541 @default.
- W4283642177 hasConcept C185592680 @default.
- W4283642177 hasConcept C28859421 @default.
- W4283642177 hasConcept C41625074 @default.
- W4283642177 hasConcept C55493867 @default.
- W4283642177 hasConcept C57581600 @default.
- W4283642177 hasConcept C86803240 @default.
- W4283642177 hasConcept C88020867 @default.
- W4283642177 hasConcept C95444343 @default.
- W4283642177 hasConceptScore W4283642177C143840085 @default.
- W4283642177 hasConceptScore W4283642177C144647389 @default.
- W4283642177 hasConceptScore W4283642177C158617107 @default.
- W4283642177 hasConceptScore W4283642177C161200384 @default.
- W4283642177 hasConceptScore W4283642177C168240541 @default.
- W4283642177 hasConceptScore W4283642177C185592680 @default.
- W4283642177 hasConceptScore W4283642177C28859421 @default.