FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283643321> ?p ?o ?g. }

• W4283643321 endingPage "100289" @default.
• W4283643321 startingPage "100289" @default.
• W4283643321 abstract "Articular cartilage injury is central for the development of post-traumatic osteoarthritis (PTOA). With few disease-modifying therapies successful at offsetting progressive osteoarthritis (OA), our goal is to use a high throughput screening platform of cartilage injury to identify novel chondroprotective compounds. Targeting articular cartilage damage immediately after injury remains a promising therapeutic strategy to overcome irreversible tissue damage. We constructed a single impact-cartilage screening method using a multi-platen system that simultaneously impacts 48 samples and makes use of engineered cartilage tissue analogs (known as CTAs). Drug libraries were screened and assessed for their ability to alter two crucial biological responses to impact injuries, namely matrix degradation and cell stress. Over 500 small molecules were screened for their ability to alter proteoglycan loss, matrix metalloproteinase activity, and cell stress or death. Fifty-five compounds passed through secondary screening and were from commercial libraries of natural and redox, stem cell related compounds, as well as protease, kinase and phosphatase inhibitors. Through secondary screening, 16 promising candidates exhibited activity on one or more critical function of chondrocytes. While many are mechanistically known compounds, their function in joint diseases is not known. This platform was validated for screening drug activity against a tissue engineered model of PTOA. Multiple compounds identified in this manner have potential application as early protective therapy for treating PTOA, and require further study. We propose this screening platform can identify novel molecules that act on early chondrocyte responses to injury and provide an invaluable tool for therapeutic development." @default.
• W4283643321 created "2022-06-29" @default.
• W4283643321 creator A5004033828 @default.
• W4283643321 creator A5004544640 @default.
• W4283643321 creator A5014690472 @default.
• W4283643321 creator A5019203113 @default.
• W4283643321 creator A5021406439 @default.
• W4283643321 creator A5036412487 @default.
• W4283643321 creator A5038454601 @default.
• W4283643321 creator A5049365881 @default.
• W4283643321 creator A5074087973 @default.
• W4283643321 creator A5087105127 @default.
• W4283643321 date "2022-09-01" @default.
• W4283643321 modified "2023-10-14" @default.
• W4283643321 title "Identifying small molecules for protecting chondrocyte function and matrix integrity after controlled compressive injury" @default.
• W4283643321 cites W1586221717 @default.
• W4283643321 cites W1807713007 @default.
• W4283643321 cites W1886051612 @default.
• W4283643321 cites W1963709954 @default.
• W4283643321 cites W1966491943 @default.
• W4283643321 cites W1991729257 @default.
• W4283643321 cites W2013972979 @default.
• W4283643321 cites W2021605578 @default.
• W4283643321 cites W2029861410 @default.
• W4283643321 cites W2053115793 @default.
• W4283643321 cites W2064315321 @default.
• W4283643321 cites W2091921078 @default.
• W4283643321 cites W2093441798 @default.
• W4283643321 cites W2094618439 @default.
• W4283643321 cites W2101080130 @default.
• W4283643321 cites W2114954785 @default.
• W4283643321 cites W2130408625 @default.
• W4283643321 cites W2136663005 @default.
• W4283643321 cites W2166304583 @default.
• W4283643321 cites W2309232884 @default.
• W4283643321 cites W2312104423 @default.
• W4283643321 cites W2425593468 @default.
• W4283643321 cites W2493025049 @default.
• W4283643321 cites W2586519898 @default.
• W4283643321 cites W2735521919 @default.
• W4283643321 cites W2748551576 @default.
• W4283643321 cites W2751209884 @default.
• W4283643321 cites W2800742869 @default.
• W4283643321 cites W2883695373 @default.
• W4283643321 cites W2916830005 @default.
• W4283643321 cites W2941727130 @default.
• W4283643321 cites W2968243186 @default.
• W4283643321 cites W2980134306 @default.
• W4283643321 cites W3092097581 @default.
• W4283643321 cites W3169436064 @default.
• W4283643321 cites W3181517543 @default.
• W4283643321 doi "https://doi.org/10.1016/j.ocarto.2022.100289" @default.
• W4283643321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36474951" @default.
• W4283643321 hasPublicationYear "2022" @default.
• W4283643321 type Work @default.
• W4283643321 citedByCount "0" @default.
• W4283643321 crossrefType "journal-article" @default.
• W4283643321 hasAuthorship W4283643321A5004033828 @default.
• W4283643321 hasAuthorship W4283643321A5004544640 @default.
• W4283643321 hasAuthorship W4283643321A5014690472 @default.
• W4283643321 hasAuthorship W4283643321A5019203113 @default.
• W4283643321 hasAuthorship W4283643321A5021406439 @default.
• W4283643321 hasAuthorship W4283643321A5036412487 @default.
• W4283643321 hasAuthorship W4283643321A5038454601 @default.
• W4283643321 hasAuthorship W4283643321A5049365881 @default.
• W4283643321 hasAuthorship W4283643321A5074087973 @default.
• W4283643321 hasAuthorship W4283643321A5087105127 @default.
• W4283643321 hasBestOaLocation W42836433213 @default.
• W4283643321 hasConcept C105702510 @default.
• W4283643321 hasConcept C109523444 @default.
• W4283643321 hasConcept C126322002 @default.
• W4283643321 hasConcept C142724271 @default.
• W4283643321 hasConcept C161624437 @default.
• W4283643321 hasConcept C185592680 @default.
• W4283643321 hasConcept C204787440 @default.
• W4283643321 hasConcept C2776164576 @default.
• W4283643321 hasConcept C2780550940 @default.
• W4283643321 hasConcept C2781403057 @default.
• W4283643321 hasConcept C55493867 @default.
• W4283643321 hasConcept C60644358 @default.
• W4283643321 hasConcept C71924100 @default.
• W4283643321 hasConcept C86803240 @default.
• W4283643321 hasConcept C95444343 @default.
• W4283643321 hasConcept C98274493 @default.
• W4283643321 hasConceptScore W4283643321C105702510 @default.
• W4283643321 hasConceptScore W4283643321C109523444 @default.
• W4283643321 hasConceptScore W4283643321C126322002 @default.
• W4283643321 hasConceptScore W4283643321C142724271 @default.
• W4283643321 hasConceptScore W4283643321C161624437 @default.
• W4283643321 hasConceptScore W4283643321C185592680 @default.
• W4283643321 hasConceptScore W4283643321C204787440 @default.
• W4283643321 hasConceptScore W4283643321C2776164576 @default.
• W4283643321 hasConceptScore W4283643321C2780550940 @default.
• W4283643321 hasConceptScore W4283643321C2781403057 @default.
• W4283643321 hasConceptScore W4283643321C55493867 @default.
• W4283643321 hasConceptScore W4283643321C60644358 @default.
• W4283643321 hasConceptScore W4283643321C71924100 @default.
• W4283643321 hasConceptScore W4283643321C86803240 @default.

• next