FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283644235> ?p ?o ?g. }

• W4283644235 endingPage "860" @default.
• W4283644235 startingPage "850" @default.
• W4283644235 abstract "Abstract Abdominal aortic aneurysms (AAAs) are localized rupture-prone expansions of the aorta with limited reversibility that develop due to proteolysis of the elastic matrix. Natural regenerative repair of an elastic matrix is difficult due to the intrinsically poor elastogenicity of adult vascular smooth muscle cells (VSMCs). This justifies the need to provide external, pro-elastin regenerative- and anti-proteolytic stimuli to VSMCs in the AAA wall towards reinstating matrix structure in the aorta wall. Introducing alternative phenotypes of highly elastogenic and contractile cells into the AAA wall capable of providing such cues, proffers attractive prospects for AAA treatment. In this regard, we have previously demonstrated the superior elastogenicity of bone marrow mesenchymal stem cell (BM-MSC)-derived SMCs (cBM-SMCs) and their ability to provide pro-elastogenic and anti-proteolytic stimuli to aneurysmal SMCs in vitro. However, the major issues associated with cell therapy, such as their natural ability to home into the AAA tissue, their in vivo biodistribution and retention in the AAA wall, and possible paracrine effects on AAA tissue repair processes in the event of localization in remote tissues remain uncertain. Therefore, in this study we focused on assessing the fate, safety, and AAA reparative effects of BM-MSC-derived cBM-SMCs in vivo. Our results indicate that the cBM-SMCs (a) possess natural homing abilities similar to the undifferentiated BM-MSCs, (b) exhibit higher retention upon localization in the aneurysmal aorta than BM-MSCs, (c) downregulate the expression of several inflammatory and pro-apoptotic cytokines that are upregulated in the AAA wall contributing to accelerated elastic matrix breakdown and suppression of elastic fiber neo-assembly, repair, and crosslinking, and (d) improve elastic matrix content and structure in the AAA wall toward slowing the growth of AAAs. Our study provides initial evidence of the in vivo elastic matrix reparative benefits of cBM-SMCs and their utility in cell therapy to reverse the pathophysiology of AAAs." @default.
• W4283644235 created "2022-06-29" @default.
• W4283644235 creator A5030089397 @default.
• W4283644235 creator A5036298397 @default.
• W4283644235 creator A5068907649 @default.
• W4283644235 creator A5070731425 @default.
• W4283644235 creator A5071402317 @default.
• W4283644235 date "2022-06-27" @default.
• W4283644235 modified "2023-10-01" @default.
• W4283644235 title "Adult Mesenchymal Stem Cells and Derivatives in Improved Elastin Homeostasis in a Rat Model of Abdominal Aortic Aneurysms" @default.
• W4283644235 cites W1971218073 @default.
• W4283644235 cites W1971313047 @default.
• W4283644235 cites W1988314796 @default.
• W4283644235 cites W1991889240 @default.
• W4283644235 cites W1993010243 @default.
• W4283644235 cites W1996702326 @default.
• W4283644235 cites W2005699251 @default.
• W4283644235 cites W2024005775 @default.
• W4283644235 cites W2042060958 @default.
• W4283644235 cites W2045341839 @default.
• W4283644235 cites W2070334783 @default.
• W4283644235 cites W2075906975 @default.
• W4283644235 cites W2081279867 @default.
• W4283644235 cites W2090372122 @default.
• W4283644235 cites W2091271152 @default.
• W4283644235 cites W2111563692 @default.
• W4283644235 cites W2119692463 @default.
• W4283644235 cites W2124396531 @default.
• W4283644235 cites W2129228205 @default.
• W4283644235 cites W2155524664 @default.
• W4283644235 cites W2155553189 @default.
• W4283644235 cites W2158094210 @default.
• W4283644235 cites W2162004190 @default.
• W4283644235 cites W2166040185 @default.
• W4283644235 cites W2233044846 @default.
• W4283644235 cites W2329076138 @default.
• W4283644235 cites W2466973740 @default.
• W4283644235 cites W2476542314 @default.
• W4283644235 cites W2555659298 @default.
• W4283644235 cites W2638561866 @default.
• W4283644235 cites W2756040071 @default.
• W4283644235 cites W2777811087 @default.
• W4283644235 cites W2948232419 @default.
• W4283644235 cites W3002614207 @default.
• W4283644235 cites W3091874306 @default.
• W4283644235 cites W3136545311 @default.
• W4283644235 doi "https://doi.org/10.1093/stcltm/szac043" @default.
• W4283644235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35758561" @default.
• W4283644235 hasPublicationYear "2022" @default.
• W4283644235 type Work @default.
• W4283644235 citedByCount "3" @default.
• W4283644235 countsByYear W42836442352022 @default.
• W4283644235 countsByYear W42836442352023 @default.
• W4283644235 crossrefType "journal-article" @default.
• W4283644235 hasAuthorship W4283644235A5030089397 @default.
• W4283644235 hasAuthorship W4283644235A5036298397 @default.
• W4283644235 hasAuthorship W4283644235A5068907649 @default.
• W4283644235 hasAuthorship W4283644235A5070731425 @default.
• W4283644235 hasAuthorship W4283644235A5071402317 @default.
• W4283644235 hasBestOaLocation W42836442352 @default.
• W4283644235 hasConcept C104317684 @default.
• W4283644235 hasConcept C127561419 @default.
• W4283644235 hasConcept C142724271 @default.
• W4283644235 hasConcept C151872237 @default.
• W4283644235 hasConcept C18903297 @default.
• W4283644235 hasConcept C189165786 @default.
• W4283644235 hasConcept C198826908 @default.
• W4283644235 hasConcept C2779869378 @default.
• W4283644235 hasConcept C28328180 @default.
• W4283644235 hasConcept C55493867 @default.
• W4283644235 hasConcept C71924100 @default.
• W4283644235 hasConcept C86803240 @default.
• W4283644235 hasConcept C95444343 @default.
• W4283644235 hasConceptScore W4283644235C104317684 @default.
• W4283644235 hasConceptScore W4283644235C127561419 @default.
• W4283644235 hasConceptScore W4283644235C142724271 @default.
• W4283644235 hasConceptScore W4283644235C151872237 @default.
• W4283644235 hasConceptScore W4283644235C18903297 @default.
• W4283644235 hasConceptScore W4283644235C189165786 @default.
• W4283644235 hasConceptScore W4283644235C198826908 @default.
• W4283644235 hasConceptScore W4283644235C2779869378 @default.
• W4283644235 hasConceptScore W4283644235C28328180 @default.
• W4283644235 hasConceptScore W4283644235C55493867 @default.
• W4283644235 hasConceptScore W4283644235C71924100 @default.
• W4283644235 hasConceptScore W4283644235C86803240 @default.
• W4283644235 hasConceptScore W4283644235C95444343 @default.
• W4283644235 hasFunder F4320306230 @default.
• W4283644235 hasFunder F4320332161 @default.
• W4283644235 hasIssue "8" @default.
• W4283644235 hasLocation W42836442351 @default.
• W4283644235 hasLocation W42836442352 @default.
• W4283644235 hasLocation W42836442353 @default.
• W4283644235 hasOpenAccess W4283644235 @default.
• W4283644235 hasPrimaryLocation W42836442351 @default.
• W4283644235 hasRelatedWork W1997111006 @default.
• W4283644235 hasRelatedWork W2028358054 @default.
• W4283644235 hasRelatedWork W2164565750 @default.
• W4283644235 hasRelatedWork W2328593348 @default.

• next