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• W4283644538 endingPage "102034" @default.
• W4283644538 startingPage "102034" @default.
• W4283644538 abstract "Fatty liver hemorrhagic syndrome (FLHS) is a chronic hepatic disease which occurs when there is a disorder in lipid metabolism. FLHS is often observed in caged laying hens and characterized by a decrease in egg production and dramatic increase of mortality. Salidroside (SDS) is an herbal drug which has shown numerous pharmacological activities, such as protecting mitochondrial function, attenuating cell apoptosis and inflammation, and promoting antioxidant defense system. We aimed to determine the therapeutic effects of SDS on FLHS in laying hens and investigate the underlying mechanisms through which SDS operates these functions. We constructed oleic acid (OA)-induced fatty liver model in vitro and high-fat diet-induced FLHS of laying hens in vivo. The results indicated that SDS inhibited OA-induced lipid accumulation in chicken primary hepatocytes, increased hepatocyte activity, elevated the mRNA expression of proliferation related genes PCNA, CDK2, and cyclinD1 and increased the protein levels of PCNA and CDK2 (P < 0.05), as well as decreased the cleavage levels of Caspase-9, Caspase-8, and Caspase-3 and apoptosis in hepatocytes (P < 0.05). Moreover, SDS promoted the phosphorylation levels of PDK1, AKT, and Gsk3-β, while inhibited the PI3K inhibitor (P < 0.05). Additionally, we found that high-fat diet-induced FLHS hens had heavier body weight, liver weight, and abdominal fat weight, and severe steatosis in histology, compared with the control group (Con). However, hens fed with SDS maintained lighter body weight, liver weight, and abdominal fat weight, as well as normal liver without hepatic steatosis. In addition, high-fat diet-induced FLHS hens had high levels of serum total cholesterol (TC), triglyceride (TG), alanine transaminase (ALT), and aspartate aminotransferase (AST) compared to the Con group, however, in the Model+SDS group, the levels of TC, TG, ALT, and AST decreased significantly, whereas the level of superoxide dismutase (SOD) increased significantly (P < 0.05). We also found that SDS significantly decreased the mRNA expression abundance of PPARγ, SCD, and FAS in the liver, as well as increased levels of PPARα and MTTP, and decreased the mRNA expression of TNF-α, IL-1β, IL-6, and IL-8 in the Model+SDS group (P < 0.05). In summary, this study showed that 0.3 mg/mL SDS attenuated ROS generation, inhibited lipid accumulation and hepatocyte apoptosis, and promoted hepatocyte proliferation by targeting the PI3K/AKT/Gsk3-β pathway in OA-induced fatty liver model in vitro, and 20 mg/kg SDS alleviated high-fat-diet-induced hepatic steatosis, oxidative stress, and inflammatory response in laying hens in vivo." @default.
• W4283644538 created "2022-06-29" @default.
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• W4283644538 date "2022-09-01" @default.
• W4283644538 modified "2023-10-17" @default.
• W4283644538 title "Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3-β pathway" @default.
• W4283644538 cites W1742552685 @default.
• W4283644538 cites W1961403824 @default.
• W4283644538 cites W1965878277 @default.
• W4283644538 cites W1969660985 @default.
• W4283644538 cites W1970008652 @default.
• W4283644538 cites W1971351365 @default.
• W4283644538 cites W1976783841 @default.
• W4283644538 cites W1977194186 @default.
• W4283644538 cites W1978679812 @default.
• W4283644538 cites W1978902825 @default.
• W4283644538 cites W1990104746 @default.
• W4283644538 cites W2006241936 @default.
• W4283644538 cites W2014436128 @default.
• W4283644538 cites W2018567893 @default.
• W4283644538 cites W2020731590 @default.
• W4283644538 cites W2023195072 @default.
• W4283644538 cites W2028698925 @default.
• W4283644538 cites W2036518843 @default.
• W4283644538 cites W2044269687 @default.
• W4283644538 cites W2053265248 @default.
• W4283644538 cites W2053629454 @default.
• W4283644538 cites W2079021980 @default.
• W4283644538 cites W2080848479 @default.
• W4283644538 cites W2094501366 @default.
• W4283644538 cites W2100267724 @default.
• W4283644538 cites W2100764155 @default.
• W4283644538 cites W2101501368 @default.
• W4283644538 cites W2103492275 @default.
• W4283644538 cites W2107277218 @default.
• W4283644538 cites W2111045432 @default.
• W4283644538 cites W2114513863 @default.
• W4283644538 cites W2115497342 @default.
• W4283644538 cites W2133055418 @default.
• W4283644538 cites W2137880179 @default.
• W4283644538 cites W2153158893 @default.
• W4283644538 cites W2165289842 @default.
• W4283644538 cites W2177327442 @default.
• W4283644538 cites W2233007490 @default.
• W4283644538 cites W2262210329 @default.
• W4283644538 cites W2289740209 @default.
• W4283644538 cites W2339813221 @default.
• W4283644538 cites W2439901648 @default.
• W4283644538 cites W2606876974 @default.
• W4283644538 cites W2610037213 @default.
• W4283644538 cites W2610656095 @default.
• W4283644538 cites W2733864134 @default.
• W4283644538 cites W2791125028 @default.
• W4283644538 cites W2884398985 @default.
• W4283644538 cites W2884830888 @default.
• W4283644538 cites W2887016559 @default.
• W4283644538 cites W2894739542 @default.
• W4283644538 cites W2897624976 @default.
• W4283644538 cites W2942770263 @default.
• W4283644538 cites W2954005699 @default.
• W4283644538 cites W2957470668 @default.
• W4283644538 cites W2990669162 @default.
• W4283644538 cites W2998014224 @default.
• W4283644538 cites W3039644747 @default.
• W4283644538 cites W3087592148 @default.
• W4283644538 cites W3095173321 @default.
• W4283644538 cites W3110815224 @default.
• W4283644538 cites W3118894383 @default.
• W4283644538 cites W3132922273 @default.
• W4283644538 cites W3175218263 @default.
• W4283644538 cites W4293282159 @default.
• W4283644538 cites W774691086 @default.
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• W4283644538 doi "https://doi.org/10.1016/j.psj.2022.102034" @default.
• W4283644538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35926351" @default.
• W4283644538 hasPublicationYear "2022" @default.
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