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- W4283644580 abstract "Lung cancer is a public health problem and the first cause of cancer death worldwide. Radon is a radioactive gas that tends to accumulate inside homes, and it is the second lung cancer risk factor after smoking, and the first one in non-smokers. In Europe, there are several radon-prone areas, and although the 2013/59 EURATOM directive is aimed to regulate indoor radon exposition, regulating measures can vary between countries. Radon emits alpha-ionizing radiation that has been linked to a wide variety of cytotoxic and genotoxic effects; however, the link between lung cancer and radon from the genomic point of view remains poorly described. Driver molecular alterations have been recently identified in non-small lung cancer (NSCLC), such as somatic mutations (EGFR, BRAF, HER2, MET) or chromosomal rearrangements (ALK, ROS1, RET, NTRK), mainly in the non-smoking population, where no risk factor has been identified yet. An association between radon exposure and oncogenic NSCLC in non-smokers has been hypothesised. This paper provides a practical, concise and updated review on the implications of indoor radon in lung cancer carcinogenesis, and especially of its potential relation with NSCLC with driver genomic alterations." @default.
- W4283644580 created "2022-06-29" @default.
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- W4283644580 date "2022-06-27" @default.
- W4283644580 modified "2023-10-09" @default.
- W4283644580 title "Radon and Lung Cancer: Current Trends and Future Perspectives" @default.
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- W4283644580 doi "https://doi.org/10.3390/cancers14133142" @default.
- W4283644580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35804914" @default.
- W4283644580 hasPublicationYear "2022" @default.
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