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- W4283645225 abstract "SUMMARY Although touch and itch are coded by distinct neuronal populations, light touch also provokes itch in the presence of exogenous pruritogens, resulting in a phenomenon called alloknesis. However, the cellular and molecular mechanisms underlying the initiation of pruritogen-induced mechanical itch sensitization are poorly understood. Here we show that intradermal injections of histamine or chloroquine (CQ) provoke alloknesis through activation of TRPV1- and MrgprA3- expressing prurioceptors, and functional ablation of these neurons reverses pruritogen-induced alloknesis. Moreover, genetic ablation of mechanosensitive Piezo2 channel function from MrgprA3-expressing prurioceptors also dampens pruritogen-induced alloknesis. Mechanistically, histamine and CQ sensitize Piezo2 channel function through activation of the PLC-PKCδ signaling. Collectively, our data uncovered a TRPV1 + /MrgprA3 + prurioceptor-Piezo2 signaling axis in the initiation of pruritogen-induced mechanical itch sensitization in the skin." @default.
- W4283645225 created "2022-06-29" @default.
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- W4283645225 date "2022-06-26" @default.
- W4283645225 modified "2023-10-17" @default.
- W4283645225 title "MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel" @default.
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- W4283645225 doi "https://doi.org/10.1101/2022.06.22.497257" @default.
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