Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283658590> ?p ?o ?g. }
- W4283658590 endingPage "1991" @default.
- W4283658590 startingPage "1971" @default.
- W4283658590 abstract "Abstract Ischemic stroke, which accounts for nearly 80% of all strokes, leads to white matter injury and neurobehavioral dysfunction, but relevant therapies to inhibit demyelination or promote remyelination after white matter injury are still unavailable. In this study, the middle cerebral artery occlusion/reperfusion (MCAO/R) in vivo and oxygen–glucose deprivation/reoxygenation (OGD/R) in vitro were used to establish the ischemic models. We found that Eph receptor A4 (EphA4) had no effect on the apoptosis of oligodendrocytes using TUNEL staining. In contrast, EphA4 promoted proliferation of oligodendrocyte precursor cells (OPCs), but reduced the numbers of mature oligodendrocytes and the levels of myelin‐associated proteins (MAG, MOG, and MBP) in the process of remyelination in ischemic models in vivo and in vitro as determined using PDGFRα‐EphA4‐shRNA and LV‐EphA4 treatments. Notably, conditional knockout of EphA4 in OPCs (EphA4 fl/fl + AAV‐PDGFRα‐Cre) improved the levels of myelin‐associated proteins and functional recovery following ischemic stroke. In addition, regulation of remyelination by EphA4 was mediated by the Ephexin‐1/RhoA/ROCK signaling pathway. Therefore, EphA4 did not affect oligodendrocyte (OL) apoptosis but regulated white matter remyelination after ischemic stroke through the Ephexin‐1/RhoA/ROCK signaling pathway. EphA4 may provide a novel and effective therapeutic target in clinical practice of ischemic stroke." @default.
- W4283658590 created "2022-06-29" @default.
- W4283658590 creator A5009787820 @default.
- W4283658590 creator A5015894529 @default.
- W4283658590 creator A5061949032 @default.
- W4283658590 creator A5065208984 @default.
- W4283658590 creator A5072310857 @default.
- W4283658590 creator A5081842390 @default.
- W4283658590 date "2022-06-28" @default.
- W4283658590 modified "2023-10-16" @default.
- W4283658590 title "EphA4 regulates white matter remyelination after ischemic stroke through Ephexin‐1/RhoA/ROCK signaling pathway" @default.
- W4283658590 cites W1983097317 @default.
- W4283658590 cites W1990232805 @default.
- W4283658590 cites W1992085076 @default.
- W4283658590 cites W1993354361 @default.
- W4283658590 cites W2000401553 @default.
- W4283658590 cites W2003225294 @default.
- W4283658590 cites W2004225433 @default.
- W4283658590 cites W2006632421 @default.
- W4283658590 cites W2008640695 @default.
- W4283658590 cites W2012349037 @default.
- W4283658590 cites W2024671559 @default.
- W4283658590 cites W2027201372 @default.
- W4283658590 cites W2046335099 @default.
- W4283658590 cites W2088358598 @default.
- W4283658590 cites W2101866426 @default.
- W4283658590 cites W2102883376 @default.
- W4283658590 cites W2110626319 @default.
- W4283658590 cites W2114272337 @default.
- W4283658590 cites W2142077499 @default.
- W4283658590 cites W2142736033 @default.
- W4283658590 cites W2148399486 @default.
- W4283658590 cites W2155477484 @default.
- W4283658590 cites W2158063724 @default.
- W4283658590 cites W2159532873 @default.
- W4283658590 cites W2165222962 @default.
- W4283658590 cites W2171365654 @default.
- W4283658590 cites W2210658805 @default.
- W4283658590 cites W2280414742 @default.
- W4283658590 cites W2336345979 @default.
- W4283658590 cites W2485096444 @default.
- W4283658590 cites W2492785636 @default.
- W4283658590 cites W2575573238 @default.
- W4283658590 cites W2598105256 @default.
- W4283658590 cites W2608444058 @default.
- W4283658590 cites W2731917886 @default.
- W4283658590 cites W2789332623 @default.
- W4283658590 cites W2802560140 @default.
- W4283658590 cites W2887371472 @default.
- W4283658590 cites W2898250069 @default.
- W4283658590 cites W2906115446 @default.
- W4283658590 cites W2916928860 @default.
- W4283658590 cites W2981580343 @default.
- W4283658590 cites W2994770641 @default.
- W4283658590 cites W2999651813 @default.
- W4283658590 cites W3012324491 @default.
- W4283658590 cites W3019236150 @default.
- W4283658590 cites W3019681744 @default.
- W4283658590 cites W3023689210 @default.
- W4283658590 cites W3030141222 @default.
- W4283658590 cites W3083062804 @default.
- W4283658590 cites W3089903916 @default.
- W4283658590 cites W3091894398 @default.
- W4283658590 cites W3098074281 @default.
- W4283658590 cites W3102243125 @default.
- W4283658590 cites W3112950760 @default.
- W4283658590 cites W3127505971 @default.
- W4283658590 cites W3194488502 @default.
- W4283658590 doi "https://doi.org/10.1002/glia.24232" @default.
- W4283658590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35762396" @default.
- W4283658590 hasPublicationYear "2022" @default.
- W4283658590 type Work @default.
- W4283658590 citedByCount "4" @default.
- W4283658590 countsByYear W42836585902023 @default.
- W4283658590 crossrefType "journal-article" @default.
- W4283658590 hasAuthorship W4283658590A5009787820 @default.
- W4283658590 hasAuthorship W4283658590A5015894529 @default.
- W4283658590 hasAuthorship W4283658590A5061949032 @default.
- W4283658590 hasAuthorship W4283658590A5065208984 @default.
- W4283658590 hasAuthorship W4283658590A5072310857 @default.
- W4283658590 hasAuthorship W4283658590A5081842390 @default.
- W4283658590 hasBestOaLocation W42836585901 @default.
- W4283658590 hasConcept C101544691 @default.
- W4283658590 hasConcept C126838900 @default.
- W4283658590 hasConcept C143409427 @default.
- W4283658590 hasConcept C169760540 @default.
- W4283658590 hasConcept C170286479 @default.
- W4283658590 hasConcept C19331615 @default.
- W4283658590 hasConcept C2776985911 @default.
- W4283658590 hasConcept C2777093181 @default.
- W4283658590 hasConcept C2777619251 @default.
- W4283658590 hasConcept C2778609137 @default.
- W4283658590 hasConcept C2781192897 @default.
- W4283658590 hasConcept C529278444 @default.
- W4283658590 hasConcept C62478195 @default.
- W4283658590 hasConcept C71924100 @default.
- W4283658590 hasConcept C86803240 @default.
- W4283658590 hasConcept C95444343 @default.