Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283660108> ?p ?o ?g. }
- W4283660108 endingPage "1158" @default.
- W4283660108 startingPage "1158" @default.
- W4283660108 abstract "Familial hypercholesterolemia (FH) is the most common monogenic metabolic disorder characterized by considerably elevated low-density lipoprotein cholesterol (LDL-C) levels leading to enhanced atherogenesis, early cardiovascular disease (CVD), and premature death. However, the wide phenotypic heterogeneity in FH makes the cardiovascular risk prediction challenging in clinical practice to determine optimal therapeutic strategy. Beyond the lifetime LDL-C vascular accumulation, other genetic and non-genetic risk factors might exacerbate CVD development. Besides the most frequent variants of three genes (LDL-R, APOB, and PCSK9) in some proband variants of other genes implicated in lipid metabolism and atherogenesis are responsible for FH phenotype. Furthermore, non-genetic factors, including traditional cardiovascular risk factors, metabolic and endocrine disorders might also worsen risk profile. Although some were extensively studied previously, others, such as common endocrine disorders including thyroid disorders or polycystic ovary syndrome are not widely evaluated in FH. In this review, we summarize the most important genetic and non-genetic factors that might affect the risk prediction and therapeutic strategy in FH through the eyes of clinicians focusing on disorders that might not be in the center of FH research. The review highlights the complexity of FH care and the need of an interdisciplinary attitude to find the best therapeutic approach in FH patients." @default.
- W4283660108 created "2022-06-29" @default.
- W4283660108 creator A5001001124 @default.
- W4283660108 creator A5002306496 @default.
- W4283660108 creator A5020282164 @default.
- W4283660108 creator A5065913278 @default.
- W4283660108 creator A5068207317 @default.
- W4283660108 creator A5078212370 @default.
- W4283660108 creator A5082046471 @default.
- W4283660108 date "2022-06-27" @default.
- W4283660108 modified "2023-10-06" @default.
- W4283660108 title "Clinical Aspects of Genetic and Non-Genetic Cardiovascular Risk Factors in Familial Hypercholesterolemia" @default.
- W4283660108 cites W1520291128 @default.
- W4283660108 cites W1598864384 @default.
- W4283660108 cites W1910270001 @default.
- W4283660108 cites W1964011698 @default.
- W4283660108 cites W1967782399 @default.
- W4283660108 cites W1969752275 @default.
- W4283660108 cites W1975099097 @default.
- W4283660108 cites W1978804351 @default.
- W4283660108 cites W1979570442 @default.
- W4283660108 cites W1979830634 @default.
- W4283660108 cites W1980484085 @default.
- W4283660108 cites W1981743756 @default.
- W4283660108 cites W1989026300 @default.
- W4283660108 cites W1990183405 @default.
- W4283660108 cites W1991614042 @default.
- W4283660108 cites W1994636715 @default.
- W4283660108 cites W1995792918 @default.
- W4283660108 cites W2003470341 @default.
- W4283660108 cites W2011727092 @default.
- W4283660108 cites W2019757445 @default.
- W4283660108 cites W2022272653 @default.
- W4283660108 cites W2026539275 @default.
- W4283660108 cites W2033879310 @default.
- W4283660108 cites W2046494933 @default.
- W4283660108 cites W2058902344 @default.
- W4283660108 cites W2060962757 @default.
- W4283660108 cites W2069616685 @default.
- W4283660108 cites W2070726933 @default.
- W4283660108 cites W2078911852 @default.
- W4283660108 cites W2081535404 @default.
- W4283660108 cites W2081688325 @default.
- W4283660108 cites W2088101486 @default.
- W4283660108 cites W2091410379 @default.
- W4283660108 cites W2091655302 @default.
- W4283660108 cites W2094484989 @default.
- W4283660108 cites W2098438225 @default.
- W4283660108 cites W2098890974 @default.
- W4283660108 cites W2102179430 @default.
- W4283660108 cites W2103108681 @default.
- W4283660108 cites W2103734592 @default.
- W4283660108 cites W2105612671 @default.
- W4283660108 cites W2111631364 @default.
- W4283660108 cites W2114013331 @default.
- W4283660108 cites W2115913745 @default.
- W4283660108 cites W2126904069 @default.
- W4283660108 cites W2129166365 @default.
- W4283660108 cites W2130117548 @default.
- W4283660108 cites W2130869061 @default.
- W4283660108 cites W2138494153 @default.
- W4283660108 cites W2140936682 @default.
- W4283660108 cites W2143987962 @default.
- W4283660108 cites W2144950094 @default.
- W4283660108 cites W2147446436 @default.
- W4283660108 cites W2147663252 @default.
- W4283660108 cites W2150969208 @default.
- W4283660108 cites W2152704335 @default.
- W4283660108 cites W2153491818 @default.
- W4283660108 cites W2156184134 @default.
- W4283660108 cites W2156674697 @default.
- W4283660108 cites W2157305411 @default.
- W4283660108 cites W2164271065 @default.
- W4283660108 cites W2164486163 @default.
- W4283660108 cites W2164565204 @default.
- W4283660108 cites W2167130513 @default.
- W4283660108 cites W2171018041 @default.
- W4283660108 cites W2280202036 @default.
- W4283660108 cites W2286999219 @default.
- W4283660108 cites W2293940476 @default.
- W4283660108 cites W2345841042 @default.
- W4283660108 cites W238811865 @default.
- W4283660108 cites W2410774145 @default.
- W4283660108 cites W2491324259 @default.
- W4283660108 cites W2509568995 @default.
- W4283660108 cites W2513021883 @default.
- W4283660108 cites W2522418769 @default.
- W4283660108 cites W2529318943 @default.
- W4283660108 cites W2540256559 @default.
- W4283660108 cites W2547670829 @default.
- W4283660108 cites W2560906050 @default.
- W4283660108 cites W2591226747 @default.
- W4283660108 cites W2598956467 @default.
- W4283660108 cites W2605526926 @default.
- W4283660108 cites W2613816064 @default.
- W4283660108 cites W2736304346 @default.
- W4283660108 cites W2740746072 @default.
- W4283660108 cites W2743967130 @default.