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- W4283661306 abstract "Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein binding of cephalosporins in human body fluids as well as to describe patient characteristics influencing the level of protein binding. Method: A systematic literature search was performed in Embase, Medline ALL, Web of Science Core Collection and the Cochrane Central Register of Controlled Trials with the following search terms: protein binding, beta-lactam antibiotic, and body fluid. Only studies were included where protein binding was measured in humans in vivo. Results: The majority of studies reporting protein binding were performed in serum or plasma. Other fluids included pericardial fluid, blister fluid, bronchial secretion, pleural exudate, wound exudate, cerebrospinal fluid, dialysate, and peritoneal fluid. Protein binding differs between diverse cephalosporins and between different patient categories. For cefazolin, ceftriaxone, cefpiramide, and cefonicid a non-linear pattern in protein binding in serum or plasma was described. Several patient characteristics were associated with low serum albumin concentrations and were found to have lower protein binding compared to healthy volunteers. This was for critically ill patients, dialysis patients, and patients undergoing cardiopulmonary bypass during surgery. While mean/median percentages of protein binding are lower in these patient groups, individual values may vary considerably. Age is not likely to influence protein binding by itself, however limited data suggest that lower protein binding in newborns. Obesity was not correlated with altered protein binding. Discussion/Conclusion: Conclusions on protein binding in other body fluids than blood cannot be drawn due to the scarcity of data. In serum and plasma, there is a large variability in protein binding per cephalosporin and between different categories of patients. Several characteristics were identified which lead to a lower protein binding. The finding that some of the cephalosporins display a non-linear pattern of protein binding makes it even more difficult to predict the unbound concentrations in individual patients. Taken all these factors, it is recommended to measure unbound concentrations to optimize antibiotic exposure in individual patients. Systematic Review Registration: PROSPERO, identifier (CRD42021252776)." @default.
- W4283661306 created "2022-06-29" @default.
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- W4283661306 date "2022-06-28" @default.
- W4283661306 modified "2023-10-14" @default.
- W4283661306 title "An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review" @default.
- W4283661306 cites W1538508830 @default.
- W4283661306 cites W1953342538 @default.
- W4283661306 cites W1963815742 @default.
- W4283661306 cites W1963856273 @default.
- W4283661306 cites W1968708047 @default.
- W4283661306 cites W1969084312 @default.
- W4283661306 cites W1974779793 @default.
- W4283661306 cites W1974886063 @default.
- W4283661306 cites W1978371302 @default.
- W4283661306 cites W1979922634 @default.
- W4283661306 cites W1981444588 @default.
- W4283661306 cites W1983168166 @default.
- W4283661306 cites W1991512579 @default.
- W4283661306 cites W1991834896 @default.
- W4283661306 cites W1999759855 @default.
- W4283661306 cites W2005000232 @default.
- W4283661306 cites W2005089404 @default.
- W4283661306 cites W2008805832 @default.
- W4283661306 cites W2014267321 @default.
- W4283661306 cites W2014588537 @default.
- W4283661306 cites W2015826472 @default.
- W4283661306 cites W2017310620 @default.
- W4283661306 cites W2021885669 @default.
- W4283661306 cites W2022320300 @default.
- W4283661306 cites W2024408507 @default.
- W4283661306 cites W2025494879 @default.
- W4283661306 cites W2026059809 @default.
- W4283661306 cites W2026280376 @default.
- W4283661306 cites W2031803723 @default.
- W4283661306 cites W2032249399 @default.
- W4283661306 cites W2034454983 @default.
- W4283661306 cites W2037328937 @default.
- W4283661306 cites W2038628870 @default.
- W4283661306 cites W2038779441 @default.
- W4283661306 cites W2038919607 @default.
- W4283661306 cites W2048590705 @default.
- W4283661306 cites W2049811240 @default.
- W4283661306 cites W2052264066 @default.
- W4283661306 cites W2053967529 @default.
- W4283661306 cites W2053975581 @default.
- W4283661306 cites W2055015135 @default.
- W4283661306 cites W2056014331 @default.
- W4283661306 cites W2060029955 @default.
- W4283661306 cites W2062408808 @default.
- W4283661306 cites W2063063954 @default.
- W4283661306 cites W2066825829 @default.
- W4283661306 cites W2068359234 @default.
- W4283661306 cites W2068708123 @default.
- W4283661306 cites W2070486345 @default.
- W4283661306 cites W2073728193 @default.
- W4283661306 cites W2079345144 @default.
- W4283661306 cites W2081954140 @default.
- W4283661306 cites W2083648273 @default.
- W4283661306 cites W2086291756 @default.
- W4283661306 cites W2089081411 @default.
- W4283661306 cites W2089225526 @default.
- W4283661306 cites W2092449654 @default.
- W4283661306 cites W2097205258 @default.
- W4283661306 cites W2105345395 @default.
- W4283661306 cites W2105749662 @default.
- W4283661306 cites W2106761777 @default.
- W4283661306 cites W2116387123 @default.
- W4283661306 cites W2116520143 @default.
- W4283661306 cites W2117577120 @default.
- W4283661306 cites W2120963228 @default.
- W4283661306 cites W2123133774 @default.
- W4283661306 cites W2125585473 @default.
- W4283661306 cites W2128322259 @default.
- W4283661306 cites W2128394281 @default.
- W4283661306 cites W2129046462 @default.
- W4283661306 cites W2144896173 @default.
- W4283661306 cites W2152485708 @default.
- W4283661306 cites W2157622488 @default.
- W4283661306 cites W2168276530 @default.
- W4283661306 cites W2168749478 @default.
- W4283661306 cites W2169044544 @default.
- W4283661306 cites W2171722987 @default.
- W4283661306 cites W2230714698 @default.
- W4283661306 cites W2321511423 @default.
- W4283661306 cites W2337620858 @default.
- W4283661306 cites W2378937745 @default.
- W4283661306 cites W2402500540 @default.
- W4283661306 cites W2412007357 @default.
- W4283661306 cites W2414484354 @default.
- W4283661306 cites W2520511147 @default.
- W4283661306 cites W2529329782 @default.
- W4283661306 cites W2546676431 @default.