FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283661640> ?p ?o ?g. }

• W4283661640 endingPage "185" @default.
• W4283661640 startingPage "179" @default.
• W4283661640 abstract "We review macaque models for preexposure prophylaxis (PrEP) for HIV prevention and highlight their role in advancing currently approved and novel PrEP agents.The development of the repeat low dose simian HIV (SHIV) challenge models represented a significant advancement in preclinical PrEP modeling that has allowed the investigation of PrEP under conditions that better mimic HIV exposures in humans. These models incorporate relevant drug pharmacology to inform drug correlates of PrEP protection. Models of rectal, vaginal, and penile infection are now available and have been found to predict clinical efficacy of all the currently approved PrEP strategies including daily oral PrEP with the combination of emtricitabine and tenofovir disoproxil fumarate or tenofovir alafenamide, and a long-acting formulation of the integrase inhibitor cabotegravir. These models are being used to test new PrEP modalities including the nucleoside reverse transcriptase-translocation inhibitor islatravir and long-acting capsid inhibitors. The SHIV models have also been supplemented by sexually transmitted infection co-infections with Chlamydia trachomatis, Treponema pallidum or Trichomonas vaginalis to assess the impact of inflammation on PrEP efficacy.Clinical efficacy validated current PrEP macaque models supporting their continued use to advance novel PrEP agents to improve global PrEP coverage." @default.
• W4283661640 created "2022-06-29" @default.
• W4283661640 creator A5019037088 @default.
• W4283661640 creator A5027427165 @default.
• W4283661640 creator A5031077639 @default.
• W4283661640 date "2022-07-01" @default.
• W4283661640 modified "2023-10-14" @default.
• W4283661640 title "The predictive value of macaque models of preexposure prophylaxis for HIV prevention" @default.
• W4283661640 cites W1413161224 @default.
• W4283661640 cites W1868092726 @default.
• W4283661640 cites W1974810704 @default.
• W4283661640 cites W1988379994 @default.
• W4283661640 cites W1997755754 @default.
• W4283661640 cites W2003968869 @default.
• W4283661640 cites W2034503047 @default.
• W4283661640 cites W2035898942 @default.
• W4283661640 cites W2041424278 @default.
• W4283661640 cites W2045989889 @default.
• W4283661640 cites W2046348452 @default.
• W4283661640 cites W2077097712 @default.
• W4283661640 cites W2083256382 @default.
• W4283661640 cites W2097057569 @default.
• W4283661640 cites W2099724461 @default.
• W4283661640 cites W2103920597 @default.
• W4283661640 cites W2104806679 @default.
• W4283661640 cites W2109478037 @default.
• W4283661640 cites W2116605213 @default.
• W4283661640 cites W2116757171 @default.
• W4283661640 cites W2117057469 @default.
• W4283661640 cites W2119782456 @default.
• W4283661640 cites W2137461955 @default.
• W4283661640 cites W2151662515 @default.
• W4283661640 cites W2160428404 @default.
• W4283661640 cites W2162226934 @default.
• W4283661640 cites W2171689424 @default.
• W4283661640 cites W2261947884 @default.
• W4283661640 cites W2319353212 @default.
• W4283661640 cites W2319917590 @default.
• W4283661640 cites W2332061686 @default.
• W4283661640 cites W2495049002 @default.
• W4283661640 cites W2557331456 @default.
• W4283661640 cites W2637292907 @default.
• W4283661640 cites W2774560050 @default.
• W4283661640 cites W2780894850 @default.
• W4283661640 cites W2794782365 @default.
• W4283661640 cites W2883638714 @default.
• W4283661640 cites W2898055096 @default.
• W4283661640 cites W2951642511 @default.
• W4283661640 cites W2966124758 @default.
• W4283661640 cites W2982613471 @default.
• W4283661640 cites W3010551610 @default.
• W4283661640 cites W3043873656 @default.
• W4283661640 cites W3045256412 @default.
• W4283661640 cites W3105691487 @default.
• W4283661640 cites W3173329502 @default.
• W4283661640 cites W3190424399 @default.
• W4283661640 cites W3201184588 @default.
• W4283661640 cites W3204166282 @default.
• W4283661640 cites W4200094957 @default.
• W4283661640 cites W4200240829 @default.
• W4283661640 cites W4200276024 @default.
• W4283661640 cites W4200355629 @default.
• W4283661640 cites W4220976600 @default.
• W4283661640 doi "https://doi.org/10.1097/coh.0000000000000738" @default.
• W4283661640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35762371" @default.
• W4283661640 hasPublicationYear "2022" @default.
• W4283661640 type Work @default.
• W4283661640 citedByCount "1" @default.
• W4283661640 countsByYear W42836616402023 @default.
• W4283661640 crossrefType "journal-article" @default.
• W4283661640 hasAuthorship W4283661640A5019037088 @default.
• W4283661640 hasAuthorship W4283661640A5027427165 @default.
• W4283661640 hasAuthorship W4283661640A5031077639 @default.
• W4283661640 hasBestOaLocation W42836616401 @default.
• W4283661640 hasConcept C142462285 @default.
• W4283661640 hasConcept C159047783 @default.
• W4283661640 hasConcept C203014093 @default.
• W4283661640 hasConcept C2776939746 @default.
• W4283661640 hasConcept C2776983459 @default.
• W4283661640 hasConcept C2779496540 @default.
• W4283661640 hasConcept C2779778239 @default.
• W4283661640 hasConcept C2780122209 @default.
• W4283661640 hasConcept C2911190787 @default.
• W4283661640 hasConcept C2993143319 @default.
• W4283661640 hasConcept C3013748606 @default.
• W4283661640 hasConcept C71924100 @default.
• W4283661640 hasConcept C98274493 @default.
• W4283661640 hasConceptScore W4283661640C142462285 @default.
• W4283661640 hasConceptScore W4283661640C159047783 @default.
• W4283661640 hasConceptScore W4283661640C203014093 @default.
• W4283661640 hasConceptScore W4283661640C2776939746 @default.
• W4283661640 hasConceptScore W4283661640C2776983459 @default.
• W4283661640 hasConceptScore W4283661640C2779496540 @default.
• W4283661640 hasConceptScore W4283661640C2779778239 @default.
• W4283661640 hasConceptScore W4283661640C2780122209 @default.
• W4283661640 hasConceptScore W4283661640C2911190787 @default.
• W4283661640 hasConceptScore W4283661640C2993143319 @default.
• W4283661640 hasConceptScore W4283661640C3013748606 @default.

• next