FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283687825> ?p ?o ?g. }

• W4283687825 abstract "Oncostatin M receptor (OSMR), as one of the receptors for oncostatin M (OSM), has previously been shown to mediate the stimulatory role of OSM in osteoclastogenesis and bone resorption. However, it remains to be clarified whether and how OSMR affects the differentiation of osteoblasts.The expression level of OSMR during osteoblast and adipocyte differentiation was examined. The role of OSMR in the differentiation was investigated using in vitro gain-of-function and loss-of-function experiments. The mechanisms by which OSMR regulates bone cell differentiation were explored. Finally, in vivo function of OSMR in cell fate determination and bone homeostasis was studied after transplantation of OSMR-silenced bone marrow stromal cells (BMSCs) to the marrow of ovariectomized mice.OSMR was regulated during osteogenic and adipogenic differentiation of marrow stromal progenitor cells and increased in the metaphysis of ovariectomized mice. OSMR suppressed osteogenic differentiation and stimulated adipogenic differentiation of progenitor cells. Mechanistic investigations showed that OSMR inhibited extracellular signal-regulated kinase (ERK) and autophagy signaling. The downregulation of autophagy, which was mediated by ERK inhibition, suppressed osteogenic differentiation of progenitor cells. Additionally, inactivation of ERK/autophagy signaling attenuated the stimulation of osteogenic differentiation induced by Osmr siRNA. Furthermore, transplantation of BMSCs in which OSMR was silenced to the marrow of mice promoted osteoblast differentiation, attenuated fat accumulation and osteoclast differentiation, and thereby relieved the osteopenic phenotype in the ovariectomized mice.Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis." @default.
• W4283687825 created "2022-06-30" @default.
• W4283687825 creator A5005477478 @default.
• W4283687825 creator A5008037802 @default.
• W4283687825 creator A5019573704 @default.
• W4283687825 creator A5028552727 @default.
• W4283687825 creator A5050792044 @default.
• W4283687825 creator A5055353570 @default.
• W4283687825 creator A5073064156 @default.
• W4283687825 creator A5082116966 @default.
• W4283687825 date "2022-06-28" @default.
• W4283687825 modified "2023-10-15" @default.
• W4283687825 title "Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling" @default.
• W4283687825 cites W1507243371 @default.
• W4283687825 cites W1718175705 @default.
• W4283687825 cites W1923333065 @default.
• W4283687825 cites W1983220846 @default.
• W4283687825 cites W1987354408 @default.
• W4283687825 cites W1988974838 @default.
• W4283687825 cites W1991231767 @default.
• W4283687825 cites W1991687240 @default.
• W4283687825 cites W1996058081 @default.
• W4283687825 cites W1996679752 @default.
• W4283687825 cites W1999801453 @default.
• W4283687825 cites W2003098906 @default.
• W4283687825 cites W2003158379 @default.
• W4283687825 cites W2013406943 @default.
• W4283687825 cites W2027270135 @default.
• W4283687825 cites W2049089797 @default.
• W4283687825 cites W2057035809 @default.
• W4283687825 cites W2059850320 @default.
• W4283687825 cites W2060498510 @default.
• W4283687825 cites W2064237012 @default.
• W4283687825 cites W2074029585 @default.
• W4283687825 cites W2081195720 @default.
• W4283687825 cites W2096068577 @default.
• W4283687825 cites W2098586364 @default.
• W4283687825 cites W2108086395 @default.
• W4283687825 cites W2108281583 @default.
• W4283687825 cites W2108298020 @default.
• W4283687825 cites W2115222878 @default.
• W4283687825 cites W2124797640 @default.
• W4283687825 cites W2140860403 @default.
• W4283687825 cites W2158186990 @default.
• W4283687825 cites W2169763871 @default.
• W4283687825 cites W2314262864 @default.
• W4283687825 cites W2511863849 @default.
• W4283687825 cites W2548729637 @default.
• W4283687825 cites W2582886339 @default.
• W4283687825 cites W2588681757 @default.
• W4283687825 cites W2604780989 @default.
• W4283687825 cites W2763904814 @default.
• W4283687825 cites W2765903743 @default.
• W4283687825 cites W2772087535 @default.
• W4283687825 cites W2811363562 @default.
• W4283687825 cites W2901241915 @default.
• W4283687825 cites W2914305568 @default.
• W4283687825 cites W2919577856 @default.
• W4283687825 cites W2947674806 @default.
• W4283687825 cites W2972593585 @default.
• W4283687825 cites W2977335680 @default.
• W4283687825 cites W2997897178 @default.
• W4283687825 cites W3091517308 @default.
• W4283687825 cites W3150346933 @default.
• W4283687825 cites W4233865846 @default.
• W4283687825 doi "https://doi.org/10.1186/s13287-022-02958-1" @default.
• W4283687825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35765036" @default.
• W4283687825 hasPublicationYear "2022" @default.
• W4283687825 type Work @default.
• W4283687825 citedByCount "1" @default.
• W4283687825 countsByYear W42836878252023 @default.
• W4283687825 crossrefType "journal-article" @default.
• W4283687825 hasAuthorship W4283687825A5005477478 @default.
• W4283687825 hasAuthorship W4283687825A5008037802 @default.
• W4283687825 hasAuthorship W4283687825A5019573704 @default.
• W4283687825 hasAuthorship W4283687825A5028552727 @default.
• W4283687825 hasAuthorship W4283687825A5050792044 @default.
• W4283687825 hasAuthorship W4283687825A5055353570 @default.
• W4283687825 hasAuthorship W4283687825A5073064156 @default.
• W4283687825 hasAuthorship W4283687825A5082116966 @default.
• W4283687825 hasBestOaLocation W42836878251 @default.
• W4283687825 hasConcept C104317684 @default.
• W4283687825 hasConcept C11988809 @default.
• W4283687825 hasConcept C122927707 @default.
• W4283687825 hasConcept C126322002 @default.
• W4283687825 hasConcept C134018914 @default.
• W4283687825 hasConcept C148738053 @default.
• W4283687825 hasConcept C16930146 @default.
• W4283687825 hasConcept C170493617 @default.
• W4283687825 hasConcept C185592680 @default.
• W4283687825 hasConcept C198826908 @default.
• W4283687825 hasConcept C201750760 @default.
• W4283687825 hasConcept C202751555 @default.
• W4283687825 hasConcept C203014093 @default.
• W4283687825 hasConcept C2776033226 @default.
• W4283687825 hasConcept C2777667943 @default.
• W4283687825 hasConcept C2778260815 @default.
• W4283687825 hasConcept C2778690821 @default.
• W4283687825 hasConcept C28328180 @default.
• W4283687825 hasConcept C502942594 @default.

• next