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• W4283687836 abstract "PARP inhibitors (PARPis) were initially developed as DNA repair inhibitors that inhibit the catalytic activity of PARP1 and PARP2 and are expected to induce synthetic lethality in BRCA- or homologous recombination (HR)-deficient tumors. However, the clinical indications for PARPis are not necessarily limited to BRCA mutations or HR deficiency; BRCA wild-type and HR-proficient cancers can also derive some benefit from PARPis. These facts are interpretable by an additional primary antitumor mechanism of PARPis named PARP trapping, resulting from the stabilization of PARP-DNA complexes. Favorable response to platinum derivatives (cisplatin and carboplatin) in preceding treatment is used as a clinical biomarker for some PARPis, implying that sensitivity factors for platinum derivatives and PARPis are mainly common. Such common sensitivity factors include not only HR defects (HRD) but also additional factors. One of them is Schlafen 11 (SLFN11), a putative DNA/RNA helicase, that sensitizes cancer cells to a broad type of DNA-damaging agents, including platinum and topoisomerase inhibitors. Mechanistically, SLFN11 induces a lethal replication block in response to replication stress (ie, DNA damage). As SLFN11 acts upon replication stress, trapping PARPis can activate SLFN11. Preclinical models show the importance of SLFN11 in PARPi sensitivity. However, the relevance of SLFN11 in PARPi response is less evident in clinical data compared with the significance of SLFN11 for platinum sensitivity. In this review, we consider the reasons for variable indications of PARPis resulting from clinical outcomes and review the mechanisms of action for PARPis as anticancer agents." @default.
• W4283687836 created "2022-06-30" @default.
• W4283687836 creator A5070187819 @default.
• W4283687836 creator A5074228660 @default.
• W4283687836 date "2022-07-16" @default.
• W4283687836 modified "2023-10-14" @default.
• W4283687836 title "Reconsidering the mechanisms of action of <scp>PARP</scp> inhibitors based on clinical outcomes" @default.
• W4283687836 cites W1972623885 @default.
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• W4283687836 cites W2043398720 @default.
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• W4283687836 cites W2111437716 @default.
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• W4283687836 cites W2130078242 @default.
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• W4283687836 doi "https://doi.org/10.1111/cas.15477" @default.
• W4283687836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35766436" @default.
• W4283687836 hasPublicationYear "2022" @default.
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