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- W4283689477 abstract "Background Rheumatoid arthritis (RA) is a common chronic autoimmune disease involving multiple joint symmetry. The main pathological changes are fibroblast like synovial (FLS) cell proliferation and bone destruction. Circular RNA (circrna) is a special type of noncoding RNA formed by reverse splicing of linear RNA, which has high stability in organisms. Research shows that circ_ 0003972 is a circrna found to be significantly up-regulated in RA patients in recent years, and its level is significantly positively correlated with DAS28 score and patients with joint tenderness (Wen et al, 2020b)[1]. However, The role of CIRC_0003972 in the pathological progression of RA synovium has not been confirmed. Our research aims to reveal Role of Circ_0003972. Objectives Circular RNAs (circrnas) have been shown to play an important role in the progression of RA. The purpose of this study is to explore Circ_ 0003972 Role and mechanism of in the progression of RA. Methods The gene expression was determined by real-time quantitative PCR. The proliferation and apoptosis of human RA fibroblast like synovial (fls-ra) cells were measured by cell counting kit 8, edu staining and flow cytometry. Western blot analysis was performed to measure protein expression, and ELISA was used to check the concentration of inflammatory factors. Double luciferase reporter gene detection and rip detection confirmed mir-654-5p and Interaction between Circ_0003972. Results Circ_0003972 is expressed in RA patients and fls-ra cells. Circ_ 0003972 knockdown inhibits proliferation and inflammation and promotes TNF-α Flra-induced apoptosis. Mir-654-5p is down regulated in RA patients and fls-RA cells, and it can be expressed by Circ_ 0003972 absorption. Mir-654-5p inhibitor reversed Circ_0003972 silencing on TNF-α Effects of induced hfls-RA on cell proliferation, inflammation and apoptosis. Conclusion Circ_0003972 may promote the proliferation and inflammation of FLS-RA cells and accelerate the pathological progress of RA by regulating mir-654-5p. References [1]Wen J, Liu J, Zhang P, et al. RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis[J]. Bioscience Reports, 2020, 40(4). Disclosure of Interests None declared." @default.
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- W4283689477 date "2022-05-23" @default.
- W4283689477 modified "2023-09-26" @default.
- W4283689477 title "POS0437 CIRC_ 0003972 STUDY ON FIBROBLAST LIKE SYNOVIAL CELLS IN RHEUMATOID ARTHRITIS THROUGH IMMUNE REGULATION" @default.
- W4283689477 doi "https://doi.org/10.1136/annrheumdis-2022-eular.4326" @default.
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