Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283690622> ?p ?o ?g. }
- W4283690622 abstract "Photoreceptors consume glucose supplied by the choriocapillaris to support phototransduction and outer segment (OS) renewal. Reduced glucose supply underlies photoreceptor cell death in inherited retinal degeneration and age-related retinal disease. We have previously shown that restricting glucose transport into the outer retina by conditional deletion of Slc2a1 encoding GLUT1 resulted in photoreceptor loss and impaired OS renewal. However, retinal neurons, glia, and the retinal pigment epithelium play specialized, synergistic roles in metabolite supply and exchange, and the cell-specific map of glucose uptake and utilization in the retina is incomplete. In these studies, we conditionally deleted Slc2a1 in a pan-retinal or rod-specific manner to better understand how glucose is utilized in the retina. Using non-invasive ocular imaging, electroretinography, and histochemical and biochemical analyses we show that genetic deletion of Slc2a1 from retinal neurons and Müller glia results in reduced OS growth and progressive rod but not cone photoreceptor cell death. Rhodopsin levels were severely decreased even at postnatal day 20 when OS length was relatively normal. Arrestin levels were not changed suggesting that glucose uptake is required to synthesize membrane glycoproteins. Rod-specific deletion of Slc2a1 resulted in similar changes in OS length and rod photoreceptor cell death. These studies demonstrate that glucose is an essential carbon source for rod photoreceptor cell OS maintenance and viability." @default.
- W4283690622 created "2022-06-30" @default.
- W4283690622 creator A5003233728 @default.
- W4283690622 creator A5024900490 @default.
- W4283690622 creator A5031964348 @default.
- W4283690622 creator A5033915515 @default.
- W4283690622 creator A5044008862 @default.
- W4283690622 creator A5047985485 @default.
- W4283690622 creator A5048944005 @default.
- W4283690622 creator A5051841096 @default.
- W4283690622 creator A5070205434 @default.
- W4283690622 creator A5076745450 @default.
- W4283690622 creator A5078550327 @default.
- W4283690622 creator A5081648765 @default.
- W4283690622 creator A5090087970 @default.
- W4283690622 date "2022-06-29" @default.
- W4283690622 modified "2023-10-15" @default.
- W4283690622 title "Glucose uptake by <scp>GLUT1</scp> in photoreceptors is essential for outer segment renewal and rod photoreceptor survival" @default.
- W4283690622 cites W1501502189 @default.
- W4283690622 cites W1555812953 @default.
- W4283690622 cites W1596751131 @default.
- W4283690622 cites W1651402379 @default.
- W4283690622 cites W1900343592 @default.
- W4283690622 cites W1915214953 @default.
- W4283690622 cites W1968996277 @default.
- W4283690622 cites W1970710520 @default.
- W4283690622 cites W1980237107 @default.
- W4283690622 cites W1985382030 @default.
- W4283690622 cites W1997696781 @default.
- W4283690622 cites W2010673579 @default.
- W4283690622 cites W2014611118 @default.
- W4283690622 cites W2016631311 @default.
- W4283690622 cites W2017551130 @default.
- W4283690622 cites W2027162538 @default.
- W4283690622 cites W2029657491 @default.
- W4283690622 cites W2034927169 @default.
- W4283690622 cites W2042277760 @default.
- W4283690622 cites W2045411437 @default.
- W4283690622 cites W2049349550 @default.
- W4283690622 cites W2051168573 @default.
- W4283690622 cites W2053971665 @default.
- W4283690622 cites W2059344357 @default.
- W4283690622 cites W2063991093 @default.
- W4283690622 cites W2065288017 @default.
- W4283690622 cites W2067113611 @default.
- W4283690622 cites W2079178498 @default.
- W4283690622 cites W2095167143 @default.
- W4283690622 cites W2102016516 @default.
- W4283690622 cites W2117869378 @default.
- W4283690622 cites W2119433891 @default.
- W4283690622 cites W2122367003 @default.
- W4283690622 cites W2122977730 @default.
- W4283690622 cites W2129618668 @default.
- W4283690622 cites W2132528145 @default.
- W4283690622 cites W2133740745 @default.
- W4283690622 cites W2135300477 @default.
- W4283690622 cites W2140128594 @default.
- W4283690622 cites W2145694460 @default.
- W4283690622 cites W2148952902 @default.
- W4283690622 cites W2149250742 @default.
- W4283690622 cites W2160550697 @default.
- W4283690622 cites W2164597697 @default.
- W4283690622 cites W2167279371 @default.
- W4283690622 cites W2190832897 @default.
- W4283690622 cites W2218890016 @default.
- W4283690622 cites W2298457819 @default.
- W4283690622 cites W2316782837 @default.
- W4283690622 cites W2334456088 @default.
- W4283690622 cites W2590528398 @default.
- W4283690622 cites W2604399914 @default.
- W4283690622 cites W2617421506 @default.
- W4283690622 cites W2765214084 @default.
- W4283690622 cites W2778853949 @default.
- W4283690622 cites W2789751261 @default.
- W4283690622 cites W2797370161 @default.
- W4283690622 cites W2805089858 @default.
- W4283690622 cites W2811137755 @default.
- W4283690622 cites W2884889241 @default.
- W4283690622 cites W2889985768 @default.
- W4283690622 cites W2891777621 @default.
- W4283690622 cites W2893675751 @default.
- W4283690622 cites W2897859321 @default.
- W4283690622 cites W2901655097 @default.
- W4283690622 cites W2907122372 @default.
- W4283690622 cites W2912309272 @default.
- W4283690622 cites W2919162407 @default.
- W4283690622 cites W2945489406 @default.
- W4283690622 cites W2949177718 @default.
- W4283690622 cites W2949802136 @default.
- W4283690622 cites W2953228787 @default.
- W4283690622 cites W2964948340 @default.
- W4283690622 cites W2968217662 @default.
- W4283690622 cites W3007657682 @default.
- W4283690622 cites W3016412874 @default.
- W4283690622 cites W3021491962 @default.
- W4283690622 cites W3022658502 @default.
- W4283690622 cites W3031175788 @default.
- W4283690622 cites W3033657812 @default.
- W4283690622 cites W3044114834 @default.
- W4283690622 cites W3093050488 @default.