FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4283695170> ?p ?o ?g. }

• W4283695170 endingPage "672" @default.
• W4283695170 startingPage "672.1" @default.
• W4283695170 abstract "Background Last-generation Ultra High-frequency ultrasound (UHFUS) transducers are highly sensitive tools for the study of tiny superficial structures such as minor labial salivary glands (MLSGs). Compared to conventional ultrasound, UHFUS operates with higher frequencies allowing for outstanding image resolution, up to 30 µm. Objectives To determine the diagnostic accuracy of MLSG UHFUS in primary Sjogren’s syndrome (pSS) and to assess its contribution in anti-Ro/SSA positive and anti-Ro/SSA negative patients Methods Consecutive patients undergoing a MLSG biopsy for clinically suspected pSS were included in this cross-sectional study from January 2018 to October 2021. MLSG UHFUS was performed by using a 70 MHz probe, evaluating parenchymal inhomogeneity (score 0-3, similar to major salivary glands four-grade OMERACT scoring system). Patients’ clinical, biological, and histological features were collected. Anti-Ro/SSA antibody specificity was determined by immunoblotting. Receiver operating characteristic (ROC) curves, optimal cut-off point, AUC (area under curve), sensitivity (SE), specificity (SP), positive (PPV) and negative predictive values (NPV) were identified. Results A total of 194 patients were enrolled. Out of them, 88 patients fulfilled the ACR/EULAR 2016 criteria for pSS and 74 were anti-Ro/SSA+ (69 pSS and 5 no-SS). The distribution of UHFUS grades was significantly different in patients with pSS than in no-SS subjects: grade 0: 0/88 (0) vs 17/106 (16%); grade 1: 28/88 (31.8%) vs 55/106 (51.9%); grade 2: 46/88 (52.3%) vs 31/106 (29.2%); grade 3: 14 (15.9%) vs 3(2.8%); p<0.0001. ROC curve analysis indicated that at the optimal cut-off value of 2, UHFUS identified pSS and no-SS patients with a SE=68.2%, a SP=67.9%, a PPV= 63.8%, and a NPV= 72% (AUC=0.722, 95%CI: 0.651-0.793) and can predict a FS≥1 at the MLSG biopsy with a SE =73%, a SP=63.4%, a PPV= 48.9% and a NPV = 83% (AUC= 0.732, 95% CI: 0.657-0.806). Subgroup analyses highlighted significant differences in UHFUS diagnostic accuracy between anti-Ro/SSA+ and anti-Ro/SSA- patients. Particularly, in the latter group UHFUS showed a higher diagnostic accuracy (AUC= 0.754, 95% CI: 0.641-0.867) with a NPV increased up to 93.3%; similarly, UHFUS showed a higher accuracy (AUC= 0.755, 95% CI: 0.650-0.860) in predicting a MLSG FS≥1 with a NPV raised up to 90.7%. Conclusion MLSG UHFUS score system presents a good SE and SP in distinguishing pSS from no-SS subjects. The diagnostic accuracy of MLSG UHFUS may be significantly enhanced when combined with anti-Ro/SSA antibodies status. If anti-SSA antibodies are negative and UHFUS grade is 0 or 1, the diagnosis of pSS is very improbable and MLSG biopsy could be avoided. Further studies are in progress to define the added value of UHFUS with respect to major salivary gland ultrasonography. Table 1. UHFUS diagnostic accuracy in pSS (A) and for predicting a MLSG FS≥1 in all the cases and in anti-Ro/SSA negative patients. OCP, optimal cut-off value. SE SP PPV NPV AUC (95%CI) OCP pSS diagnosis (all pts) 60/88 (68.2%) 72/106 (67.9%) 60/94 (63.8%) 72/100 (72%) 0.722 (0.651-0.793) 2 FS≥1 prediction (all pts) 46/63 (73%) 83/131 (63.4%) 46/94 (48.9%) 83/100 (83%) 0.732 (0.657-0.806) 2 pSS diagnosis (SSA- pts) 14/19 (73.7%) 70/101 (63.9%) 14/45 (31.1%) 70/75 (93.3% ) 0.754 (0.641-0.867) 2 FS≥1 prediction (SSA- pts) 17/24 (70.8%) 68/96 (70.8%) 17/45 (37.9%) 68/75 (90.7% ) 0.755 (0.650-0.860) 2 Figure 1. ROC curves showing UHFUS diagnostic accuracy in pSS (A) and for predicting a MLSG FS≥1 Disclosure of Interests None declared" @default.
• W4283695170 created "2022-06-30" @default.
• W4283695170 creator A5011281146 @default.
• W4283695170 creator A5015513287 @default.
• W4283695170 creator A5040590560 @default.
• W4283695170 creator A5040826502 @default.
• W4283695170 creator A5044801736 @default.
• W4283695170 creator A5046750058 @default.
• W4283695170 creator A5061585656 @default.
• W4283695170 creator A5074671121 @default.
• W4283695170 creator A5080758746 @default.
• W4283695170 date "2022-05-23" @default.
• W4283695170 modified "2023-09-27" @default.
• W4283695170 title "POS0771 ULTRA HIGH-FREQUENCY ULTRASOUND (UHFUS) OF MINOR LABIAL SALIVARY GLANDS (MLSGS): DIAGNOSTIC ACCURACY IN ANTI-Ro/SSA POSITIVE AND ANTI-Ro/SSA NEGATIVE PATIENTS WITH PRIMARY SJÖGREN’S SYNDROME (pSS)" @default.
• W4283695170 doi "https://doi.org/10.1136/annrheumdis-2022-eular.4097" @default.
• W4283695170 hasPublicationYear "2022" @default.
• W4283695170 type Work @default.
• W4283695170 citedByCount "0" @default.
• W4283695170 crossrefType "journal-article" @default.
• W4283695170 hasAuthorship W4283695170A5011281146 @default.
• W4283695170 hasAuthorship W4283695170A5015513287 @default.
• W4283695170 hasAuthorship W4283695170A5040590560 @default.
• W4283695170 hasAuthorship W4283695170A5040826502 @default.
• W4283695170 hasAuthorship W4283695170A5044801736 @default.
• W4283695170 hasAuthorship W4283695170A5046750058 @default.
• W4283695170 hasAuthorship W4283695170A5061585656 @default.
• W4283695170 hasAuthorship W4283695170A5074671121 @default.
• W4283695170 hasAuthorship W4283695170A5080758746 @default.
• W4283695170 hasBestOaLocation W42836951701 @default.
• W4283695170 hasConcept C126322002 @default.
• W4283695170 hasConcept C126838900 @default.
• W4283695170 hasConcept C142724271 @default.
• W4283695170 hasConcept C143753070 @default.
• W4283695170 hasConcept C2775934546 @default.
• W4283695170 hasConcept C2989005 @default.
• W4283695170 hasConcept C58471807 @default.
• W4283695170 hasConcept C71924100 @default.
• W4283695170 hasConcept C76318530 @default.
• W4283695170 hasConcept C90924648 @default.
• W4283695170 hasConceptScore W4283695170C126322002 @default.
• W4283695170 hasConceptScore W4283695170C126838900 @default.
• W4283695170 hasConceptScore W4283695170C142724271 @default.
• W4283695170 hasConceptScore W4283695170C143753070 @default.
• W4283695170 hasConceptScore W4283695170C2775934546 @default.
• W4283695170 hasConceptScore W4283695170C2989005 @default.
• W4283695170 hasConceptScore W4283695170C58471807 @default.
• W4283695170 hasConceptScore W4283695170C71924100 @default.
• W4283695170 hasConceptScore W4283695170C76318530 @default.
• W4283695170 hasConceptScore W4283695170C90924648 @default.
• W4283695170 hasIssue "Suppl 1" @default.
• W4283695170 hasLocation W42836951701 @default.
• W4283695170 hasOpenAccess W4283695170 @default.
• W4283695170 hasPrimaryLocation W42836951701 @default.
• W4283695170 hasRelatedWork W2143548977 @default.
• W4283695170 hasRelatedWork W2169398516 @default.
• W4283695170 hasRelatedWork W2190153870 @default.
• W4283695170 hasRelatedWork W2371831862 @default.
• W4283695170 hasRelatedWork W2739394660 @default.
• W4283695170 hasRelatedWork W2782695287 @default.
• W4283695170 hasRelatedWork W2905398573 @default.
• W4283695170 hasRelatedWork W4280549677 @default.
• W4283695170 hasRelatedWork W4286728626 @default.
• W4283695170 hasRelatedWork W4301393857 @default.
• W4283695170 hasVolume "81" @default.
• W4283695170 isParatext "false" @default.
• W4283695170 isRetracted "false" @default.
• W4283695170 workType "article" @default.