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- W4283696985 startingPage "100139" @default.
- W4283696985 abstract "As a “marker of self”, CD47 is expressed on the surface of all cells in humans, mice, and other mammals to inhibit phagocytic destruction of normal cells through interacting with signal regulatory protein α (SIRPα) on the macrophages and dendritic cells and sending a “don’t eat me” signal. Unfortunately, multiple types of cancer cells take advantage of this “don’t eat me” signal by overexpressing CD47 on their surface to evade recognition by the macrophages and avoid immune surveillance. Thus, the blockage of the CD47-SIRPα axis may be a promising therapeutic target for cancer therapy. However, CD47-targeted therapies can most likely cause serious side effects such as anemia due to the widespread expression of CD47 in normal tissues, thereby, the precise delivery of CD47-targeted therapeutics is a key part in increasing clinical efficacies and reducing side effects. In addition, the “don’t eat me” signal can also be exploited to design anti-phagocytic drug delivery systems to enhance circulation time in blood and accumulation in tumor sites. In this review, we focus on the two parts of CD47-SIRPα axis in the tumor therapy, one is the accurate delivery of CD47-targeted therapeutics by well-designed delivery systems, the other is the rational design of CD47 based anti-phagocytic drug delivery systems." @default.
- W4283696985 created "2022-06-30" @default.
- W4283696985 creator A5017061461 @default.
- W4283696985 creator A5024292782 @default.
- W4283696985 creator A5029884410 @default.
- W4283696985 creator A5049918202 @default.
- W4283696985 creator A5056892585 @default.
- W4283696985 date "2022-09-01" @default.
- W4283696985 modified "2023-10-18" @default.
- W4283696985 title "CD47-SIRPα axis in cancer therapy: Precise delivery of CD47-targeted therapeutics and design of anti-phagocytic drug delivery systems" @default.
- W4283696985 cites W1481796756 @default.
- W4283696985 cites W1496549373 @default.
- W4283696985 cites W1519311536 @default.
- W4283696985 cites W1843302206 @default.
- W4283696985 cites W1900545099 @default.
- W4283696985 cites W1964738368 @default.
- W4283696985 cites W1965067289 @default.
- W4283696985 cites W1980052502 @default.
- W4283696985 cites W1989195046 @default.
- W4283696985 cites W2001570963 @default.
- W4283696985 cites W2002220495 @default.
- W4283696985 cites W2011076421 @default.
- W4283696985 cites W2028407058 @default.
- W4283696985 cites W2028890259 @default.
- W4283696985 cites W2029435311 @default.
- W4283696985 cites W2037048276 @default.
- W4283696985 cites W2039949492 @default.
- W4283696985 cites W2040062469 @default.
- W4283696985 cites W2052382519 @default.
- W4283696985 cites W2057774884 @default.
- W4283696985 cites W2067632426 @default.
- W4283696985 cites W2068052762 @default.
- W4283696985 cites W2073608758 @default.
- W4283696985 cites W2089881927 @default.
- W4283696985 cites W2090857531 @default.
- W4283696985 cites W2092246736 @default.
- W4283696985 cites W2092705900 @default.
- W4283696985 cites W2094548766 @default.
- W4283696985 cites W2097126393 @default.
- W4283696985 cites W2099647980 @default.
- W4283696985 cites W2102869104 @default.
- W4283696985 cites W2118205675 @default.
- W4283696985 cites W2120426523 @default.
- W4283696985 cites W2127026192 @default.
- W4283696985 cites W2127122881 @default.
- W4283696985 cites W2133725847 @default.
- W4283696985 cites W2141638428 @default.
- W4283696985 cites W2157737388 @default.
- W4283696985 cites W2158298066 @default.
- W4283696985 cites W2169515956 @default.
- W4283696985 cites W2205886515 @default.
- W4283696985 cites W2212777275 @default.
- W4283696985 cites W2228271062 @default.
- W4283696985 cites W2252550602 @default.
- W4283696985 cites W2281299635 @default.
- W4283696985 cites W2295526061 @default.
- W4283696985 cites W2298233360 @default.
- W4283696985 cites W2337939199 @default.
- W4283696985 cites W2409952208 @default.
- W4283696985 cites W2413777416 @default.
- W4283696985 cites W2570685768 @default.
- W4283696985 cites W2624616322 @default.
- W4283696985 cites W2640326035 @default.
- W4283696985 cites W2750778799 @default.
- W4283696985 cites W2783899879 @default.
- W4283696985 cites W2791342692 @default.
- W4283696985 cites W2791483720 @default.
- W4283696985 cites W2794683780 @default.
- W4283696985 cites W2795487963 @default.
- W4283696985 cites W2797968236 @default.
- W4283696985 cites W2802794587 @default.
- W4283696985 cites W2809836106 @default.
- W4283696985 cites W2883164386 @default.
- W4283696985 cites W2885552659 @default.
- W4283696985 cites W2887437160 @default.
- W4283696985 cites W2889895672 @default.
- W4283696985 cites W2899385931 @default.
- W4283696985 cites W2900833416 @default.
- W4283696985 cites W2902979010 @default.
- W4283696985 cites W2911112422 @default.
- W4283696985 cites W2912396287 @default.
- W4283696985 cites W2912472580 @default.
- W4283696985 cites W2914389412 @default.
- W4283696985 cites W2918786033 @default.
- W4283696985 cites W2920905579 @default.
- W4283696985 cites W2921090220 @default.
- W4283696985 cites W2942669148 @default.
- W4283696985 cites W2944907759 @default.
- W4283696985 cites W2947337364 @default.
- W4283696985 cites W2947885335 @default.
- W4283696985 cites W2954587554 @default.
- W4283696985 cites W2955245896 @default.
- W4283696985 cites W2955317546 @default.
- W4283696985 cites W2956287834 @default.
- W4283696985 cites W2960371755 @default.
- W4283696985 cites W2971006194 @default.
- W4283696985 cites W2977354137 @default.
- W4283696985 cites W2985892902 @default.