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• W4283697025 abstract "Background The optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that can detect flow and provide information about the vessel density (VD) at different layers in the eye. The ocular microvascular network has been only occasionally addressed as disease target in scleroderma (SSc) considering the relatively low prevalence of ocular symptoms in these patients. Objectives The study aims to evaluate retinal and choriocapillaris microvasculature in a group of SSc patients compared to matched controls (HC)and according to disease characteristics, capillaroscopy findings and pulmonary function tests. Methods VD was assessed through OCTA at the retinal superficial (SCP) and deep (DCP) capillary plexus, at the foveal avascular zone perimeter (FAZP) and at the choriocapillaris (CC) of 30 SSc patients compared to 30 sex- and age-matched subjects without any retinal disease. Results The SSc patients (age 57.3±10.0, female 86.7%) had diffuse cutaneous skin disease in 30.0% of the cases, an average disease duration of 10.4±7.2 yy, and anti-centromere and anti-Scl70 antibody positivity in 40.0%and in 30.0% of the cases, respectively. Compared to the HC, SSc showed an impaired VD at SCP (47.7±3.6 vs59.1±3.5%, p=0.009), DCP (50.0±6.7 vs 54.3±6.4%, p=0.015), FAZP (48.7±4.55 vs 51.0±3.55%, p=0.034) and CC(67.1±2.2 vs 68.6±1.7, p=.005). Moreover, in the SSc group, the presence of digital ulcers (46.7%),telangiectasias (43.3%) and interstitial lung disease (46.7%) was related to reduced VD at FAZP (46.8±4.1 vs50.3±4.3%, p=0.033), CC (66.1±1.4 vs 67.9±2.4%, p=0.004), and DCP (47.2±8.8 vs 51.9±4.3, p=0.004),respectively. Lastly, the average capillary density on capillaroscopy showed a positive correlation with VD at FAZP (r=0.474, p=0.008), DCP (r=0.414, p=0.023), and foveal CC (r=0.482, p=0.007) and there was also a correlation between CC and both DLco (r=0.467, p=0.009) and FVC/DLco (r=-0.436, p=0.004). Conclusion The SSc patients in our cohort showed lower ocular vessel density at different levels compared to HC. Furthermore, impaired VD at different levels of the eye correlates with the organ involvement and the degree of digital and pulmonary microvascular impairment. According to those data, the OCTA could be proposed as a biomarker tool to investigate the microvascular abnormalities in SSc. Disclosure of Interests None declared" @default.
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• W4283697025 date "2022-05-23" @default.
• W4283697025 modified "2023-10-01" @default.
• W4283697025 title "POS0887 CHORIORETINAL MICROVASCULAR INVOLVEMENT IN SYSTEMIC SCLEROSIS" @default.
• W4283697025 doi "https://doi.org/10.1136/annrheumdis-2022-eular.3043" @default.
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