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• W4283700212 abstract "Background The relationship between cardiovascular risk (CVR) and inflammatory rheumatic diseases (IRD) remains certain [1]. The aggressive suppression of systemic inflammation by the CsDMARDs or biologics may lower this risk. Objectives The purpose of this study was to assess the protective role of the different treatments in rheumatoid arthritis (RA) and spondyloarthritis (SpA). Methods We carried out 107 patients followed up for IRD between March and December 2020. We collected the socio-demographic data of patients, the clinical and biological characteristics of the disease. Prescribed treatments were specified. CVR was assessed by measuring, in centimeters, the Intima-media Thickness (IMT) at the level of the left (LCC) and right (RCC) common carotid arteries and by calculating the Framingham risk score (FRS) for each patient. Individuals with IMT≥0.9 mm or an FRS≥20% were considered as those with high CVR (HCVR). Results Of the 107 surveyed patients, 56% had RA (n=47) and 44% had SpA (n=60). Among them, 55% were male. The mean age was 43.9±14.2 years. The mean disease duration was 117.3±89 months. The mean BASDAI was 4.98 ±2.7. The mean DAS28 was 4.13±1.5. Seventy percent of patients had active disease. Conventional DMARDs were prescribed in 54.7% of cases: Methotrexate (95% in RA versus 5% in SpA) and Sulfasalazine (13% in RA versus 30% in SpA), NSAIDs in 57.3% of patients (4.5% in RA versus 96.6% in SpA), corticosteroids (CT) in 25% (47.5% in RA versus 8.5% in SpA), and biotherapy in 9% of cases (12.8% in RA versus 6.7% in SpA). The mean FRS was 5.98 ± 6.6. The mean IMT was 0.58±0.15. About 60% of patients were considered with HCVR. NSAIDs were associated with an increase in IMT in the LCC (p<0.001) and in the RCC (p<0.001). MTX had a significant protective effect on IMT in LCC (p=0.001). However, there was no association between CT use and IMT. Regarding FCS, no significant association was found based on MTX (p=0.09), NSAIDs (p=0.11), CT (p=0.45) nor biologic use (p= 0.74). Conclusion In our study, patients taking MTX had a lower IMT than those not taking this molecule. NSAIDs were associated with an increase in IMT. However, we didn’t observe any effect of CT and biologic treatment on CVR in our population. References [1]Cho SK, Kim D, Won S, Lee J, Park B, Jang EJ, Bae SC, Sung YK. Impact of anti-rheumatic treatment on cardiovascular risk in Asian patients with rheumatoid arthritis. Semin Arthritis Rheum. 2018;47(4):501-506. Disclosure of Interests None declared" @default.
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• W4283700212 date "2022-05-23" @default.
• W4283700212 modified "2023-09-30" @default.
• W4283700212 title "AB0285 MTX REDUCED THE CARDIOVASCULAR RISK IN RHEUMATIC DISEASES" @default.
• W4283700212 doi "https://doi.org/10.1136/annrheumdis-2022-eular.3181" @default.
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